Detailed information for compound 1068230

Basic information

Technical information
  • TDR Targets ID: 1068230
  • Name: 2-[5-methoxy-4-oxo-2-(piperidin-1-ylmethyl)py ridin-1-yl]-N-(2,4,6-trimethylphenyl)acetamid e
  • MW: 397.511 | Formula: C23H31N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.15 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cn(CC(=O)Nc2c(C)cc(cc2C)C)c(cc1=O)CN1CCCCC1
  • InChi: 1S/C23H31N3O3/c1-16-10-17(2)23(18(3)11-16)24-22(28)15-26-14-21(29-4)20(27)12-19(26)13-25-8-6-5-7-9-25/h10-12,14H,5-9,13,15H2,1-4H3,(H,24,28)
  • InChiKey: IATIWHAINVBQBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[5-methoxy-4-oxo-2-(1-piperidylmethyl)-1-pyridyl]-N-(2,4,6-trimethylphenyl)acetamide
  • 2-[4-keto-5-methoxy-2-(piperidinomethyl)-1-pyridyl]-N-(2,4,6-trimethylphenyl)acetamide
  • 2-[5-methoxy-4-oxo-2-(piperidin-1-ylmethyl)pyridin-1-yl]-N-(2,4,6-trimethylphenyl)ethanamide
  • G876-0011
  • NCGC00137629-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0053 0.058 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.004 0.0062
Trichomonas vaginalis ran, putative 0.0021 0.0174 0.0542
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.02 0.0623
Brugia malayi nuclear receptor NHR-88 0.001 0.004 0.0035
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0108 0.2981
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0108 0.0195
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.5124 0.512
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0027
Toxoplasma gondii hypothetical protein 0.0247 0.2995 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.004 0.0062
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.001 0.004 0.0036
Schistosoma mansoni hypothetical protein 0.001 0.004 0.0063
Toxoplasma gondii aldehyde dehydrogenase 0.0179 0.2155 0.7156
Onchocerca volvulus 0.0053 0.058 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1047 0.2031
Loa Loa (eye worm) hypothetical protein 0.0098 0.1139 0.3067
Schistosoma mansoni lamin 0.0053 0.058 0.1118
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0027
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.004 0.0062
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0259 0.9667
Schistosoma mansoni hypothetical protein 0.0031 0.0304 0.0578
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0259 0.9525
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0259 0.9525
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.0572
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0108 0.01
Echinococcus granulosus lamin 0.0053 0.058 0.1118
Loa Loa (eye worm) hypothetical protein 0.0052 0.0568 0.1487
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.004 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.004 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.004 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.004 0.0032
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.02 0.7322
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0259 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.004 0.0062
Echinococcus granulosus FTZ F1 alpha 0.001 0.004 0.0062
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0108 0.0319
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0108 0.0195
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0259 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.007 0.0122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0304 0.0756
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0693 0.1338
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.001 0.004 0.0028
Echinococcus multilocularis GPCR, family 2 0.0031 0.0304 0.0296
Plasmodium falciparum importin beta, putative 0.0028 0.0266 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.058 0.1521
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.004 0.0032
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.001 0.004 0.0063
Echinococcus granulosus snurportin 1 0.0299 0.3644 0.7107
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0174 0.5921
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.001 0.004 0.0008
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0247 0.2995 0.8204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0247 0.2995 0.8204
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1047 0.2814
Leishmania major importin beta-1 subunit, putative 0.0023 0.02 0.0756
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.004 0.0032
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.001 0.004 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.004 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.004 0.0032
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0179 0.2155 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1047 0.104
Echinococcus granulosus betaine aldehyde dehydrogenase 0.001 0.004 0.0063
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0108 0.0319
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0108 0.0228
Echinococcus granulosus cpg binding protein 0.0031 0.0304 0.0578
Mycobacterium ulcerans glutaminase 0.0264 0.3213 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.02 0.0623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.004 0.0027
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.001 0.004 0.0032
Brugia malayi hypothetical protein 0.0142 0.1692 0.5222
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.007 0.0062
Brugia malayi hypothetical protein 0.0027 0.0259 0.0722
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0237 0.0448
Entamoeba histolytica hypothetical protein 0.0142 0.1692 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0266 0.0765
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0174 0.0456
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0108 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.004 0.0032
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0259 0.0739
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0027
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0108 0.3084
Echinococcus multilocularis snurportin 1 0.0299 0.3644 0.3639
Entamoeba histolytica hypothetical protein 0.0023 0.02 0.0969
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.004 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0067 0.0752 0.1998
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.004 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0027
Brugia malayi nuclear hormone receptor 0.001 0.004 0.0035
Echinococcus multilocularis FTZ F1 alpha 0.001 0.004 0.0032
Plasmodium vivax importin-beta 2, putative 0.0028 0.0266 1
Loa Loa (eye worm) glutaminase 0.0264 0.3213 0.8808
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.004 0.0035
Brugia malayi ecdysteroid receptor 0.001 0.004 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.004 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.061 0.1928
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.2155 0.6664
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0272 0.0764
Brugia malayi CXXC zinc finger family protein 0.0029 0.0283 0.0797
Brugia malayi glutaminase DH11.1 0.0264 0.3213 1
Schistosoma mansoni cpg binding protein 0.0029 0.0283 0.0537
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0179 0.2155 0.2148
Leishmania major hypothetical protein, conserved 0.0027 0.0259 0.1033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1047 0.104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.2155 0.6664
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0027
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.004 0.0062
Brugia malayi Importin beta-1 subunit 0.0028 0.0266 0.0746
Brugia malayi RNA, U transporter 1 0.008 0.091 0.2767
Loa Loa (eye worm) intermediate filament protein 0.0053 0.058 0.1521
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.004 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.004 0.0035
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0174 0.6125
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.001 0.004 0.0028
Echinococcus granulosus intermediate filament protein 0.0053 0.058 0.1118
Schistosoma mansoni importin beta-1 0.0028 0.0266 0.0505
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.004 0.0062
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0108 0.0228
Loa Loa (eye worm) aldehyde dehydrogenase 0.001 0.004 0.0028
Brugia malayi steroid hormone receptor 0.001 0.004 0.0035
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0108 0.01
Echinococcus granulosus lamin dm0 0.0053 0.058 0.1118
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.001 0.004 0.0032
Schistosoma mansoni ran 0.0021 0.0174 0.0325
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0108 0.3084
Schistosoma mansoni cpg binding protein 0.0031 0.0304 0.0578
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.004 0.0062
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.001 0.004 0.5
Schistosoma mansoni coup transcription factor 0.001 0.004 0.0062
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.001 0.004 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1047 0.3198
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0266 0.0258
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.004 0.0063
Onchocerca volvulus 0.0029 0.0283 0.4498
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.004 0.0063
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0174 0.4189
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0237 0.0229
Schistosoma mansoni hypothetical protein 0.0067 0.0752 0.1455
Loa Loa (eye worm) hypothetical protein 0.0053 0.058 0.1521
Echinococcus multilocularis lamin 0.0053 0.058 0.0572
Brugia malayi Steroid receptor seven-up type 2 0.001 0.004 0.0035
Echinococcus granulosus geminin 0.0329 0.4026 0.7853
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0028
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0752 0.2271
Schistosoma mansoni ran 0.0021 0.0174 0.0325
Loa Loa (eye worm) hypothetical protein 0.0247 0.2995 0.8204
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1139 0.3485
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.001 0.004 0.0063
Schistosoma mansoni transcription factor LCR-F1 0.0142 0.1692 0.3291
Schistosoma mansoni intermediate filament proteins 0.0053 0.058 0.1118
Echinococcus multilocularis musashi 0.0053 0.058 0.0572
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.004 0.0035
Schistosoma mansoni hypothetical protein 0.0012 0.007 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1047 0.2031
Schistosoma mansoni nuclear hormone receptor 0.001 0.004 0.0062
Loa Loa (eye worm) hypothetical protein 0.0247 0.2995 0.8204
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0108 0.01
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.001 0.004 0.0032
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0283 0.0699
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.004 0.0062
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0179 0.2155 0.4196
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.004 0.0035
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0272 0.0669
Treponema pallidum gamma-glutamyl phosphate reductase 0.001 0.004 0.5
Entamoeba histolytica hypothetical protein 0.0142 0.1692 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.004 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0266 0.0653
Schistosoma mansoni hypothetical protein 0.0299 0.3644 0.7107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.004 0.0027
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0174 0.4189
Schistosoma mansoni glutaminase 0.0264 0.3213 0.6265
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0108 0.2981
Schistosoma mansoni hypothetical protein 0.0329 0.4026 0.7853
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.001 0.004 0.0125
Brugia malayi intermediate filament protein 0.0053 0.058 0.1731
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3644 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.004 0.0035
Echinococcus granulosus dnaJ subfamily B 0.0417 0.5124 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.004 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.2155 0.4196
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0108 0.0214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1139 0.3485
Schistosoma mansoni hypothetical protein 0.0417 0.5124 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0179 0.2155 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0142 0.1692 0.3291
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0304 0.0863
Schistosoma mansoni hypothetical protein 0.0329 0.4026 0.7853
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1139 0.3067
Entamoeba histolytica hypothetical protein 0.0142 0.1692 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.004 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.2155 0.4196
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.004 0.0035
Brugia malayi isocitrate dehydrogenase 0.0015 0.0108 0.0248
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.004 0.0035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0304 0.0863
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0108 0.0248
Schistosoma mansoni hypothetical protein 0.0031 0.0304 0.0578
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.001 0.004 0.0063
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.004 0.0035
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.001 0.004 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0259 0.0632
Loa Loa (eye worm) hypothetical protein 0.0025 0.0225 0.0539
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.001 0.004 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.004 0.0032
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.001 0.004 0.0063
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.004 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0028
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.004 0.0062
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0304 0.0578
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0304 0.0296
Entamoeba histolytica Ran family GTPase 0.0021 0.0174 0.081
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0108 0.01
Schistosoma mansoni hypothetical protein 0.0031 0.0304 0.0578
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.2155 0.6664
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0304 0.0296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1047 0.2031
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.004 0.0062
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.001 0.004 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0259 0.9525
Echinococcus granulosus importin subunit beta 1 0.0028 0.0266 0.0505
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.058 0.1731
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0174 0.0398
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.004 0.0062
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0174 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.004 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.004 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.004 0.0035
Loa Loa (eye worm) steroid hormone receptor 0.001 0.004 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0304 0.0756
Echinococcus multilocularis cpg binding protein 0.0031 0.0304 0.0296
Schistosoma mansoni hypothetical protein 0.0031 0.0304 0.0578
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.004 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.0225 0.0539
Leishmania major GTP-binding protein, putative 0.0021 0.0174 0.0633
Trichomonas vaginalis glutaminase, putative 0.0264 0.3213 1
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.001 0.004 0.0032
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0174 0.0166
Trichomonas vaginalis importin beta-1, putative 0.0023 0.02 0.0623
Schistosoma mansoni lamin 0.0053 0.058 0.1118
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0174 0.0325
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.004 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.004 0.0027
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0304 0.0578
Entamoeba histolytica hypothetical protein 0.0142 0.1692 1
Echinococcus granulosus GPCR family 2 0.0031 0.0304 0.0578
Brugia malayi hypothetical protein 0.0018 0.0138 0.0342
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0266 1
Schistosoma mansoni cpg binding protein 0.0031 0.0304 0.0578
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0142 0.1692 0.1685
Brugia malayi aldehyde dehydrogenase 0.001 0.004 0.0036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0174 0.6125
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.004 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0266 1
Schistosoma mansoni hypothetical protein 0.0142 0.1692 0.3291
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0027
Brugia malayi Aldehyde dehydrogenase protein 4 0.001 0.004 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1047 0.2031
Echinococcus multilocularis lamin dm0 0.0053 0.058 0.0572
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.004 0.0062
Echinococcus multilocularis geminin 0.0329 0.4026 0.4021
Loa Loa (eye worm) glutaminase 2 0.0264 0.3213 0.8808
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.004 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.004 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1047 0.2031
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.001 0.004 0.0063
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.004 0.0063

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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