Detailed information for compound 1074778

Basic information

Technical information
  • TDR Targets ID: 1074778
  • Name: N-(2,5-dimethoxyphenyl)quinoline-3-sulfonamid e
  • MW: 344.385 | Formula: C17H16N2O4S
  • H donors: 1 H acceptors: 3 LogP: 2.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NS(=O)(=O)c1cnc2c(c1)cccc2)OC
  • InChi: 1S/C17H16N2O4S/c1-22-13-7-8-17(23-2)16(10-13)19-24(20,21)14-9-12-5-3-4-6-15(12)18-11-14/h3-11,19H,1-2H3
  • InChiKey: WVDCKURRTXWSOX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dimethoxyphenyl)-3-quinolinesulfonamide
  • MLS-0146285.0001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glyceraldehyde-3-phosphate dehydrogenase Starlite/ChEMBL No references
Homo sapiens alkaline phosphatase, liver/bone/kidney Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 Get druggable targets OG5_126628 All targets in OG5_126628
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus alkaline phosphatase intestinal gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania braziliensis glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium parvum glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K01077 alkaline phosphatase [EC3.1.3.1], putative Get druggable targets OG5_126976 All targets in OG5_126976
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum ko:K00134 glyceraldehyde 3-phosphate dehydrogenase [EC1.2.1.12], putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium knowlesi glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Cryptosporidium hominis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), related Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Babesia bovis glyceraldehyde-3-phosphate dehydrogenase protein Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium berghei glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative glyceraldehyde-3-phosphate dehydrogenase 293 aa 259 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable reductase 0.0109 0.391 0.8691
Schistosoma mansoni survival motor neuron protein 0.0049 0.1095 0.1121
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2634 0.311
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0227 0.0835
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2634 0.2966
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0196 0.7965 0.7944
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2634 0.311
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.105 0.3969
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.105 0.0844
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2634 0.2966
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.2634 0.2972
Loa Loa (eye worm) glutathione reductase 0.0048 0.105 0.1045
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2634 0.2966
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2634 0.311
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0082 0.2634 0.2966
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0196 0.7965 0.7933
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1318 0.12
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.391 0.8691
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2634 0.2534
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1318 0.1165
Brugia malayi Pre-SET motif family protein 0.0211 0.8643 0.8659
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0227 0.0053
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0196 0.7965 0.7933
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1095 0.1097
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2634 0.5
Schistosoma mansoni hypothetical protein 0.0049 0.1095 0.1121
Plasmodium falciparum thioredoxin reductase 0.0048 0.105 0.3969
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.391 0.8691
Plasmodium falciparum glutathione reductase 0.0048 0.105 0.3969
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2634 1
Brugia malayi hypothetical protein 0.024 0.9981 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.391 0.8691
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2634 0.2972
Schistosoma mansoni hypothetical protein 0.0172 0.6817 0.8517
Schistosoma mansoni alkaline phosphatase 0.0196 0.7965 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.105 0.2106
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2634 0.2966
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2634 0.2972
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2634 0.311
Schistosoma mansoni hypothetical protein 0.0102 0.3571 0.4321
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2634 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.4478 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.4478 1
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.2634 0.5
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.2634 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0082 0.2634 1
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.886 1
Echinococcus granulosus alkaline phosphatase 0.0196 0.7965 0.7944
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1318 0.1313
Onchocerca volvulus 0.0049 0.1095 0.0888
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0008 0.0009
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1318 0.1118
Plasmodium vivax glutathione reductase, putative 0.0048 0.105 0.3969
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.391 0.8691
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2634 0.2972
Loa Loa (eye worm) hypothetical protein 0.0054 0.1318 0.1313
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2634 0.2534
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.4478 1
Trypanosoma brucei trypanothione reductase 0.0048 0.105 0.1177
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1318 0.1313
Toxoplasma gondii thioredoxin reductase 0.0048 0.105 0.3969
Trypanosoma brucei hypothetical protein, conserved 0.0216 0.886 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2634 0.2534
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0008 0.0009
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.105 0.1045
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.4478 1
Echinococcus granulosus intestinal type alkaline phosphatase 0.0196 0.7965 0.7944
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.2634 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0227 0.022
Brugia malayi Pre-SET motif family protein 0.003 0.0227 0.0228
Echinococcus multilocularis geminin 0.0172 0.6817 0.6756
Brugia malayi glutathione reductase 0.0048 0.105 0.1052
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2634 0.2534
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0196 0.7965 0.7944
Plasmodium vivax SET domain protein, putative 0.003 0.0227 0.0835
Schistosoma mansoni alkaline phosphatase 0.0196 0.7965 1
Brugia malayi hypothetical protein 0.0026 0.0008 0.0008
Brugia malayi Thioredoxin reductase 0.0048 0.105 0.1052
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2634 0.2972
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2634 0.2467
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.2634 0.2972
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0082 0.2634 0.5
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0196 0.7965 0.7933
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.2634 0.2972
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1318 0.12
Echinococcus granulosus geminin 0.0172 0.6817 0.6774
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2634 0.2534
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.105 0.1185
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1316 0.1485
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.886 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1316 0.1485
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0028 0.0134 0.0134
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.391 0.8691
Leishmania major trypanothione reductase 0.0048 0.105 0.1177
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0082 0.2634 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.105 0.0892
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.9981 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2634 0.2467
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.2634 0.2639
Schistosoma mansoni hypothetical protein 0.0172 0.6817 0.8517
Leishmania major hypothetical protein, conserved 0.0216 0.886 1
Loa Loa (eye worm) hypothetical protein 0.024 0.9981 1
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0054 0.1316 0.1477
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2634 0.2507
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2634 0.2507
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.391 0.8691
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.8643 0.8658
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0082 0.2634 0.5
Echinococcus multilocularis alkaline phosphatase 0.0196 0.7965 0.7933
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.1451 0.1448
Echinococcus granulosus survival motor neuron protein 1 0.024 0.9981 1
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.1451 0.1448
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2634 0.5
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1316 0.1477
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0082 0.2634 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assay ChEMBL. 19821572
IC50 (binding) > 10 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 10 uM PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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