Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0114 | 0.0454 | 0.0611 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0267 | 0.3142 | 0.7462 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0287 | 0.3499 | 0.5 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0412 | 0.5699 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.3499 | 0.9999 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0412 | 0.5699 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0287 | 0.3499 | 0.6062 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0114 | 0.0454 | 0.0611 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.3499 | 0.9999 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.0112 | 0.0197 |
Loa Loa (eye worm) | serotonin transporter b | 0.0234 | 0.256 | 0.438 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.0112 | 0.0197 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.0112 | 0.5 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0412 | 0.5699 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0412 | 0.5699 | 0.3384 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0412 | 0.5699 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0114 | 0.0454 | 0.0611 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0412 | 0.5699 | 1 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0412 | 0.5699 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.0112 | 0.5 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0412 | 0.5699 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0234 | 0.256 | 0.438 |
Trypanosoma brucei | Enriched in surface-labeled proteome protein 12 | 0.0114 | 0.0454 | 0.0611 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0412 | 0.5699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.256 | 0.438 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0412 | 0.5699 | 1 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0287 | 0.3499 | 0.6062 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0287 | 0.3499 | 0.834 |
Onchocerca volvulus | 0.0287 | 0.3499 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.256 | 0.438 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0234 | 0.256 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0234 | 0.256 | 0.4491 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0412 | 0.5699 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0412 | 0.5699 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0234 | 0.256 | 0.438 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0114 | 0.0454 | 0.0611 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0412 | 0.5699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.256 | 0.438 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0114 | 0.0454 | 0.0611 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.0112 | 0.0285 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0412 | 0.5699 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0234 | 0.256 | 0.4491 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0412 | 0.5699 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0114 | 0.0454 | 0.0611 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0287 | 0.3499 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0114 | 0.0454 | 0.0611 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0234 | 0.256 | 0.438 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0234 | 0.256 | 0.4491 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0412 | 0.5699 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0412 | 0.5699 | 0.3384 |
Mycobacterium tuberculosis | Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) | 0.0325 | 0.4173 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.0112 | 0.0197 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0234 | 0.256 | 0.4491 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.0656 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 104 nM | Inhibition of human inosine-5'-monophosphate dehydrogenase 2 | ChEMBL. | 12014950 |
IC50 (binding) | = 104 nM | Inhibition of human inosine-5'-monophosphate dehydrogenase 2 | ChEMBL. | 12014950 |
IC50 (functional) | = 8 uM | In vitro secondary T-cell (CEM) proliferation assay | ChEMBL. | 12014950 |
IC50 (functional) | = 8 uM | In vitro secondary T-cell (CEM) proliferation assay | ChEMBL. | 12014950 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12014950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.