TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 258.231 | Formula: C9H14N4O5
H donors: 5 H acceptors: 5 LogP: -2.18 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@@H]1O[C@@H]([C@H]([C@@H]1O)O)n1cnc(c1N)C(=O)N
InChi: 1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6?,9?/m1/s1
InChiKey: RTRQQBHATOEIAF-CSXBLMGZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0672	0.0672
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0332	0.1062	0.6049
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.2235	0.7594	1
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.044	0.1433	0.1433
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0089	0.0228	0.5
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0051	0.0099	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0091	0.0091
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.044	0.1433	0.1688
Echinococcus granulosus	geminin	0.0507	0.1664	0.1664
Schistosoma mansoni	integrin alpha	0.0523	0.1719	0.1719
Plasmodium vivax	acyl-CoA synthetase, putative	0.0038	0.0054	0.0379
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.044	0.1433	0.1433
Echinococcus granulosus	peptidase Clp S14 family	0.0058	0.0123	0.0123
Leishmania major	hypothetical protein, conserved	0.2235	0.7594	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0051	0.0099	0.0561
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.044	0.1433	0.1433
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0089	0.0228	0.2197
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0332	0.1062	0.6049
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0162	0.048	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0332	0.1062	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0137	0.0137
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0099	0.0561
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0041	0.0064	0.0073
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	1
Schistosoma mansoni	glutaminase	0.0268	0.0845	0.0845
Trichomonas vaginalis	hypothetical protein	0.0046	0.0082	0.0108
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0058	0.0123	0.1752
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.044	0.1433	0.1433
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.044	0.1433	0.1433
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.044	0.1433	0.1818
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0058	0.0123	0.0123
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.044	0.1433	0.1688
Loa Loa (eye worm)	hypothetical protein	0.0289	0.0914	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0149	0.0149
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.044	0.1433	0.1818
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.2496	0.849	0.849
Loa Loa (eye worm)	hypothetical protein	0.044	0.1433	0.1433
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0254	0.0254
Loa Loa (eye worm)	glutaminase	0.0268	0.0845	0.0845
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0099	0.0046
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0332	0.1062	0.6049
Leishmania major	hypothetical protein, conserved	0.044	0.1433	0.1818
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.2235	0.7594	1
Brugia malayi	Cytochrome P450 family protein	0.0025	0.001	0.0012
Echinococcus granulosus	integrin alpha 3	0.0401	0.13	0.13
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.044	0.1433	0.1433
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0137	0.0161
Echinococcus multilocularis	protein jagged 2	0.0046	0.0082	0.0082
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0041	0.0064	0.0073
Brugia malayi	EGF-like domain containing protein	0.0046	0.0082	0.0096
Loa Loa (eye worm)	acetyltransferase	0.0144	0.0419	0.0419
Onchocerca volvulus		0.0149	0.0433	0.2527
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0218	0.0672	0.0672
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0162	0.048	1
Echinococcus granulosus	integrin alpha ps	0.0112	0.0309	0.0309
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.044	0.1433	0.1818
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0066	0.0149	0.0149
Giardia lamblia	High cysteine protein	0.0046	0.0082	0.0025
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.044	0.1433	0.1818
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Brugia malayi	EGF-like domain containing protein	0.0046	0.0082	0.0096
Toxoplasma gondii	hypothetical protein	0.0046	0.0082	0.0054
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0063	0.0063
Echinococcus multilocularis	integrin alpha ps	0.0235	0.0728	0.0728
Giardia lamblia	Hypothetical protein	0.044	0.1433	0.1384
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Loa Loa (eye worm)	hypothetical protein	0.044	0.1433	0.1433
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0433	0.0433
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.044	0.1433	0.1433
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0031	0.0028	0.0197
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.044	0.1433	0.1433
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0089	0.0228	0.0228
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0091	0.0091
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0066	0.0149	0.0149
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0332	0.1062	0.6049
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0091	0.0108
Plasmodium vivax	phosphodiesterase gamma, putative	0.044	0.1433	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.044	0.1433	0.1688
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.044	0.1433	0.1433
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0185	0.0558	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0396	0.1281	0.1281
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0099	0.0561
Echinococcus multilocularis	geminin	0.0507	0.1664	0.1664
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0089	0.0228	0.02
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0332	0.1062	0.6049
Echinococcus granulosus	fibrillin 2	0.0046	0.0082	0.0082
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.044	0.1433	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0137	0.0137
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.044	0.1433	0.1818
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0254	0.0254
Onchocerca volvulus		0.0107	0.029	0.1694
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.044	0.1433	0.1433
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Plasmodium falciparum	phosphodiesterase gamma, putative	0.044	0.1433	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0054	0.0054
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.044	0.1433	0.1818
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0069	0.0029
Brugia malayi	hypothetical protein	0.0126	0.0355	0.0418
Echinococcus granulosus	lysosomal alpha glucosidase	0.0185	0.0558	0.0558
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0051	0.0099	0.1563
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0058	0.0123	0.2099
Echinococcus multilocularis	integrin alpha ps	0.0235	0.0728	0.0728
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.044	0.1433	0.1433
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0058	0.0123	0.1752
Trypanosoma cruzi	hypothetical protein, conserved	0.044	0.1433	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0054	0.0054
Schistosoma mansoni	integrin alpha-ps	0.0122	0.0342	0.0342
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0089	0.0228	0.0228
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.2936	1	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.044	0.1433	0.8295
Echinococcus granulosus	histone lysine methyltransferase setb	0.0066	0.0149	0.0149
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.0405	0.0405
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0051	0.0099	0.0561
Echinococcus granulosus	integrin beta 2	0.1063	0.3572	0.3572
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0342	0.0342
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0137	0.0137
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Schistosoma mansoni	integrin beta subunit	0.0845	0.2824	0.2824
Giardia lamblia	Tenascin precursor	0.0046	0.0082	0.0025
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0099	0.0116
Echinococcus multilocularis	muscleblind protein 1	0.0153	0.045	0.045
Trypanosoma brucei	hypothetical protein, conserved	0.044	0.1433	0.1818
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.044	0.1433	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.044	0.1433	0.1433
Schistosoma mansoni	hypothetical protein	0.0034	0.0038	0.0038
Schistosoma mansoni	hypothetical protein	0.0062	0.0138	0.0138
Brugia malayi	RNA binding protein	0.0062	0.0137	0.0161
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0332	0.1062	0.6049
Loa Loa (eye worm)	hypothetical protein	0.0153	0.045	0.045
Brugia malayi	hypothetical protein	0.0218	0.0672	0.0791
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0332	0.1062	1
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Trichomonas vaginalis	conserved hypothetical protein	0.044	0.1433	0.8295
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Brugia malayi	hypothetical protein	0.0149	0.0433	0.051
Brugia malayi	Integrin alpha pat-2 precursor	0.0523	0.1719	0.2025
Echinococcus granulosus	adam	0.0046	0.0082	0.0082
Trichomonas vaginalis	glutaminase, putative	0.0268	0.0845	0.473
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0063	0.0138	0.0138
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Echinococcus multilocularis	fibrillin 2	0.0046	0.0082	0.0082
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0185	0.0558	0.0558
Loa Loa (eye worm)	PDE1B protein	0.044	0.1433	0.1433
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.2496	0.849	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0254	0.0254
Schistosoma mansoni	microtubule-associated protein tau	0.1493	0.5047	0.5047
Brugia malayi	Integrin beta pat-3 precursor	0.1435	0.4849	0.5711
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0066	0.0149	0.0149
Echinococcus multilocularis	fibrillin 1	0.0046	0.0082	0.0082
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0099	0.1192
Trypanosoma cruzi	hypothetical protein, conserved	0.044	0.1433	0.1818
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Schistosoma mansoni	alpha glucosidase	0.0041	0.0064	0.0064
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0396	0.1281	0.1509
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.044	0.1433	0.1433
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0089	0.0228	0.4425
Giardia lamblia	Tenascin-37	0.0046	0.0082	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0082
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0041	0.0064	0.0064
Brugia malayi	glutaminase DH11.1	0.0268	0.0845	0.0995
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.044	0.1433	0.1433
Trypanosoma cruzi	hypothetical protein, conserved	0.044	0.1433	0.1818
Brugia malayi	hypothetical protein	0.0041	0.0063	0.0075
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.044	0.1433	0.1433
Brugia malayi	EGF-like domain containing protein	0.0046	0.0082	0.0096
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0041	0.0064	0.0064
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0137	0.0137
Schistosoma mansoni	lipoxygenase	0.0063	0.0138	0.0138
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.0419	0.0419
Brugia malayi	TAR-binding protein	0.0062	0.0137	0.0161
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0069	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0099	0.0099
Echinococcus multilocularis	tumor protein p63	0.0408	0.1324	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0153	0.045	0.045
Onchocerca volvulus		0.006	0.0128	0.0748
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Trypanosoma cruzi	hypothetical protein, conserved	0.044	0.1433	0.1818
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Entamoeba histolytica	acyl-coA synthetase, putative	0.0051	0.0099	0.0417
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0038	0.0045
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0089	0.0228	0.02
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0063	0.0063
Giardia lamblia	Neurogenic locus Notch protein precursor	0.0046	0.0082	0.0025
Echinococcus multilocularis	adam	0.0046	0.0082	0.0082
Schistosoma mansoni	alpha-glucosidase	0.0159	0.047	0.047
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.044	0.1433	0.1818
Giardia lamblia	hypothetical protein	0.044	0.1433	0.1384
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0099	0.0116
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Entamoeba histolytica	hypothetical protein	0.0041	0.0063	0.0066
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0162	0.048	0.5381
Giardia lamblia	Fructose-bisphosphate aldolase	0.0332	0.1062	0.1011
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0254	0.0254
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0066	0.0149	0.0121
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0099	0.0417
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Echinococcus granulosus	muscleblind protein	0.0153	0.045	0.045
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.044	0.1433	0.8295
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0082
Trichomonas vaginalis	set domain proteins, putative	0.0522	0.1715	1
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.044	0.1433	0.1433
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0069	0.0481
Brugia malayi	Kelch motif family protein	0.0218	0.0672	0.0791
Giardia lamblia	Neurogenic locus notch-like protein	0.0046	0.0082	0.0025
Trypanosoma cruzi	hypothetical protein, conserved	0.044	0.1433	0.1818
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0099	0.0561
Plasmodium falciparum	acyl-CoA synthetase	0.0038	0.0054	0.0379
Giardia lamblia	Tenascin-X	0.0046	0.0082	0.0025
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.044	0.1433	1
Schistosoma mansoni	hypothetical protein	0.0112	0.0309	0.0309
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0041	0.0064	0.0075
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0082
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.0254	0.0254
Brugia malayi	Pre-SET motif family protein	0.0459	0.1497	0.1763
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.044	0.1433	0.1688
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Brugia malayi	Pre-SET motif family protein	0.0066	0.0149	0.0175
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.044	0.1433	0.1433
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0254	0.0254
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0051	0.0099	0.0561
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0185	0.0558	0.0558
Echinococcus granulosus	microtubule associated protein 2	0.1493	0.5047	0.5047
Loa Loa (eye worm)	hypothetical protein	0.2936	1	1
Entamoeba histolytica	hypothetical protein	0.0041	0.0063	0.0066
Echinococcus multilocularis	muscleblind protein	0.0153	0.045	0.045
Onchocerca volvulus	Huntingtin homolog	0.0126	0.0355	0.2072
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0355	0.0355
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0332	0.1062	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0063	0.0063
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.044	0.1433	0.1818
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0051	0.0099	0.0561
Trichomonas vaginalis	conserved hypothetical protein	0.044	0.1433	0.8295
Trichomonas vaginalis	teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative	0.0046	0.0082	0.0108
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.044	0.1433	0.1433
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0066	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0054	0.0054
Giardia lamblia	High cysteine protein	0.0046	0.0082	0.0025
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.044	0.1433	0.1433
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0137	0.0137
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	1
Leishmania major	cAMP-specific phosphodiesterase, putative	0.044	0.1433	0.1818
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0089	0.0228	0.1591
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0069	0.0069
Loa Loa (eye worm)	glutaminase 2	0.0268	0.0845	0.0845
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.044	0.1433	0.8295
Entamoeba histolytica	hypothetical protein	0.0041	0.0063	0.0066
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0038	0.0054	0.0166
Giardia lamblia	Tenascin-like	0.0046	0.0082	0.0025
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0137	0.0137
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1718	0.5821	0.5821
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.044	0.1433	0.1433
Echinococcus granulosus	neutral alpha glucosidase AB	0.0041	0.0064	0.0064
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0069	0.0029
Echinococcus granulosus	integrin alpha ps	0.0235	0.0728	0.0728
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0031	0.0028	0.0197
Onchocerca volvulus		0.0051	0.0099	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0054	0.0054
Trypanosoma cruzi	hypothetical protein, conserved	0.044	0.1433	0.1818
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0137	0.0137
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0459	0.1497	0.1497
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0089	0.0228	0.2197
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0057	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0355	0.0355
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0089	0.0228	0.1932
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Mycobacterium ulcerans	glutaminase	0.0268	0.0845	1
Onchocerca volvulus		0.0046	0.0082	0.0478
Onchocerca volvulus	Huntingtin homolog	0.0126	0.0355	0.2072
Schistosoma mansoni	hypothetical protein	0.0507	0.1664	0.1664
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0332	0.1062	0.6049
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0099	0.0417
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0137	0.0137
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0099	0.0099
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.044	0.1433	0.1433
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Echinococcus multilocularis	integrin beta 2	0.1063	0.3572	0.3572
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Brugia malayi	Muscleblind-like protein	0.0153	0.045	0.053
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Loa Loa (eye worm)	integrin beta-2	0.1435	0.4849	0.4849
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.0419	0.0493
Echinococcus multilocularis	integrin alpha 3	0.0401	0.13	0.13
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0066	0.0149	0.0149
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.1818
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	0.8295
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.044	0.1433	1
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0137	0.0137
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0091	0.0108
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.2936	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.0254	0.0299
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0254	0.0254
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.044	0.1433	0.1688
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0066	0.0149	0.0149
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0063	0.0141	0.0141
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0137	0.0137
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.044	0.1433	0.1818
Plasmodium falciparum	phosphodiesterase delta, putative	0.044	0.1433	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0332	0.1062	0.6049
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0099	0.0099
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0099	0.0046
Loa Loa (eye worm)	hypothetical protein	0.006	0.0128	0.0128
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0099	0.0116
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0089	0.0228	0.1591
Echinococcus multilocularis	integrin alpha ps	0.0112	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0228	0.0228
Schistosoma mansoni	integrin alpha-ps	0.0235	0.0728	0.0728
Brugia malayi	EGF-like domain containing protein	0.0046	0.0082	0.0096
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0185	0.0558	0.0558
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0069	0.0041
Onchocerca volvulus		0.0066	0.0149	0.0868
Onchocerca volvulus		0.0522	0.1715	1
Echinococcus granulosus	tumor protein p63	0.0408	0.1324	0.1324
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0254	0.0254
Mycobacterium ulcerans	hypothetical protein	0.0051	0.0099	0.0561
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.044	0.1433	0.1409
Trichomonas vaginalis	conserved hypothetical protein	0.044	0.1433	0.8295
Schistosoma mansoni	peptidase Clp (S14 family)	0.0089	0.0228	0.0228
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Entamoeba histolytica	hypothetical protein	0.0041	0.0063	0.0066
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.044	0.1433	0.1688
Schistosoma mansoni	hypothetical protein	0.0507	0.1664	0.1664
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.044	0.1433	0.1433
Loa Loa (eye worm)	integrin alpha pat-2	0.0806	0.2691	0.2691
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.2936	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0063	0.0063
Echinococcus granulosus	fibrillin 1	0.0046	0.0082	0.0082
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.044	0.1433	0.1433
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.044	0.1433	0.1433
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.2936	1	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Giardia lamblia	hypothetical protein	0.0046	0.0082	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0054	0.0054
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.044	0.1433	0.1818
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0099	0.0046
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0082
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.2496	0.849	0.849
Brugia malayi	Probable ClpP-like protease	0.0089	0.0228	0.0269
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.044	0.1433	0.1818
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0089	0.0228	1
Echinococcus multilocularis	microtubule associated protein 2	0.1493	0.5047	0.5047
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1333	0.1333
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.2936	1	1
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.2496	0.849	0.849
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0089	0.0228	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.044	0.1433	0.8295
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.2936	1	1
Plasmodium vivax	SET domain protein, putative	0.0066	0.0149	0.1039
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0041	0.0064	0.0036
Schistosoma mansoni	alpha-glucosidase	0.0159	0.047	0.047
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0063	0.0138	0.0138
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0051	0.0099	0.1192

Activities

Activity type	Activity value	Assay description	Source	Reference
MCC (functional)	> 300 ug ml-1	Antiviral activity of the compound was measured against Coxsackie virus B4 in african green monkey kidney (Vero B) cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Concentration of the compound required for microscopically detectable alteration of the normal cell morphology in PRK cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Concentration of the compound required for microscopically detectable alteration of the normal cell morphology in HeLa cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Concentration of the compound required for microscopically detectable alteration of the normal cell morphology in Vero B cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Concentration of the compound required for microscopically detectable alteration of the normal cell morphology in Wi-38 cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Herpes simplex virus (HSV-1 KOS) in rabbit kidney cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Herpes simplex virus (HSV-2 G) in rabbit kidney cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Vaccinia virus in rabbit kidney cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Vesicular stomatitis virus in rabbit kidney cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against vesicular stomatitis virus in HeLa cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Polio virus-1 in HeLa cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Coxsackie virus B4 in HeLa cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Parainfluenza virus-3 in african green monkey kidney (Vero B) cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Reo virus-1 in african green monkey kidney (Vero B) cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Sindbis virus in african green monkey kidney (Vero B) cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against forest virus in african green monkey kidney (Vero B) cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Rhino virus-1A in human diploid (WI-38) cells.	ChEMBL.	3950905
MCC (functional)	> 400 ug ml-1	Antiviral activity of the compound was measured against Rhino virus-9 in human diploid (WI-38) cells.	ChEMBL.	3950905

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 204862

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 108699