Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable aminotransferase | 0.0181 | 0.4415 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0402 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.1673 | 0.2999 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0026 | 0.0498 | 0.5 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0026 | 0.0498 | 0.0357 |
Echinococcus multilocularis | Aminotransferase class III | 0.0026 | 0.0498 | 0.0357 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.0569 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1334 | 0.1746 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0146 | 0.0296 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0146 | 0.0296 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0059 | 0.1334 | 0.2701 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0482 | 0.9555 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 0.1673 | 0.3386 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0146 | 0.0873 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.1673 | 0.2999 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.0569 | 0.0803 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0072 | 0.1673 | 0.1549 |
Echinococcus granulosus | Aminotransferase class III | 0.0026 | 0.0498 | 0.0357 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0072 | 0.1673 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 0.1673 | 0.3386 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0072 | 0.1673 | 0.2999 |
Plasmodium falciparum | ornithine aminotransferase | 0.0026 | 0.0498 | 1 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0026 | 0.0498 | 0.2975 |
Echinococcus granulosus | ornithine aminotransferase | 0.0026 | 0.0498 | 0.0357 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0057 | 0.1297 | 0.1692 |
Schistosoma mansoni | survival motor neuron protein | 0.0057 | 0.1297 | 0.2627 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.0569 | 0.0803 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0072 | 0.1673 | 1 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0181 | 0.4415 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0282 | 0.6953 | 0.6908 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.0569 | 0.043 |
Echinococcus multilocularis | geminin | 0.0202 | 0.4939 | 0.4864 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.4939 | 1 |
Echinococcus granulosus | geminin | 0.0202 | 0.4939 | 0.4864 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.4939 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0234 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.6953 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0234 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0146 | 0.0873 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0026 | 0.0498 | 0.1007 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.033 | 0.1974 |
Brugia malayi | hypothetical protein | 0.0282 | 0.6953 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.0569 | 0.0622 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.1673 | 0.2999 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0418 | 0.0846 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0026 | 0.0498 | 0.0357 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0181 | 0.4415 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0282 | 0.6953 | 0.6908 |
Onchocerca volvulus | 0.0059 | 0.1334 | 1 | |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0026 | 0.0498 | 0.5 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0026 | 0.0498 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0181 | 0.4415 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.0569 | 0.0622 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0234 | 0.5 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0012 | 0.0146 | 0.5 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0026 | 0.0498 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.3479 | 0.4896 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.1297 | 0.2627 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0181 | 0.4415 | 1 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0181 | 0.4415 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0072 | 0.1673 | 0.1549 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by agar diffusion method | ChEMBL. | 21542602 | |
Activity (functional) | Antifungal activity against Candida albicans ATCC 2091 after 24 hrs by agar diffusion method | ChEMBL. | 21542602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.