Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.1085 | 0.1229 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.061 | 0.0535 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2642 | 0.2817 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2642 | 0.3501 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2642 | 0.2946 |
Trichomonas vaginalis | MYB, putative | 0.0009 | 0.017 | 0.0002 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.061 | 0.045 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0963 | 0.0845 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.1085 | 0.1229 |
Trichomonas vaginalis | set domain proteins, putative | 0.0253 | 1 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.1445 | 0.1754 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0963 | 0.3 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2642 | 0.3501 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.1085 | 0.1034 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0071 | 0.2642 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.061 | 0.1528 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.1085 | 0.1034 |
Echinococcus multilocularis | geminin | 0.0181 | 0.7097 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.061 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.1085 | 0.0989 |
Trypanosoma brucei | cytochrome P450, putative | 0.0029 | 0.0963 | 0.3 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.061 | 0.3728 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.061 | 0.1528 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0155 | 0.6041 | 0.7118 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.061 | 0.045 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0009 | 0.017 | 0.0002 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0213 | 0.8388 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0042 | 0.1482 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0029 | 0.0963 | 0.3 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.7097 | 0.8414 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0011 | 0.0243 | 0.1486 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2642 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0155 | 0.6041 | 0.6806 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0046 | 0.1635 | 0.1492 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.061 | 0.045 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.061 | 0.043 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.061 | 0.0449 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0963 | 0.3 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.061 | 0.3349 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.1085 | 0.1229 |
Toxoplasma gondii | Myb family DNA-binding domain-containing protein | 0.0009 | 0.017 | 0.1041 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0046 | 0.1635 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.1085 | 0.1034 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.061 | 0.045 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0042 | 0.1482 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0071 | 0.2642 | 0.2817 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.8762 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0046 | 0.1635 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0029 | 0.0963 | 0.0884 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.061 | 0.3728 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.061 | 0.1528 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.1445 | 0.1754 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0042 | 0.1482 | 0.5311 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.1085 | 0.6637 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0213 | 0.8388 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0046 | 0.1635 | 0.2031 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0155 | 0.6041 | 0.846 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0155 | 0.6041 | 0.6806 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.7097 | 0.8414 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.1038 | 0.116 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.061 | 0.043 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0213 | 0.8388 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.061 | 0.1783 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.8762 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0029 | 0.0963 | 0.0845 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0213 | 0.8388 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.1085 | 0.1034 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0963 | 0.0845 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.061 | 0.0535 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0009 | 0.017 | 0.0002 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0046 | 0.1635 | 0.1492 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0963 | 0.0845 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0213 | 0.8388 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2642 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0963 | 0.0845 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0151 | 0.5866 | 0.8205 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2642 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.052 | 0.0325 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0046 | 0.1635 | 1 |
Echinococcus granulosus | geminin | 0.0181 | 0.7097 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.061 | 0.0449 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.1085 | 0.6637 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1085 | 0.0989 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0071 | 0.2642 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.061 | 0.1528 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.6 uM | Evaluated for the antioxidant property by measuring the inhibition of microsomal lipid peroxidation | ChEMBL. | 11206462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.