Detailed information for compound 1109510

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.488 | Formula: C21H30N4O3
  • H donors: 3 H acceptors: 4 LogP: 4.58 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCc1onc(n1)c1ccc(cc1)NC(=O)[C@H]1NCC[C@@H]1O
  • InChi: 1S/C21H30N4O3/c1-2-3-4-5-6-7-8-18-24-20(25-28-18)15-9-11-16(12-10-15)23-21(27)19-17(26)13-14-22-19/h9-12,17,19,22,26H,2-8,13-14H2,1H3,(H,23,27)/t17-,19-/m0/s1
  • InChiKey: IOXAZBCGKFMDCA-HKUYNNGSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingosine kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase Get druggable targets OG5_128162 All targets in OG5_128162
Schistosoma mansoni sphingoid long chain base kinase Get druggable targets OG5_128162 All targets in OG5_128162
Schistosoma mansoni sphingosine kinase A B Get druggable targets OG5_128162 All targets in OG5_128162
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128162 All targets in OG5_128162
Echinococcus granulosus sphingosine kinase 1 Get druggable targets OG5_128162 All targets in OG5_128162
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_128162 All targets in OG5_128162
Candida albicans similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase Get druggable targets OG5_128162 All targets in OG5_128162
Mycobacterium tuberculosis Conserved protein Get druggable targets OG5_128162 All targets in OG5_128162
Schistosoma japonicum ko:K00901 diacylglycerol kinase [EC2.7.1.107], putative Get druggable targets OG5_128162 All targets in OG5_128162
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128162 All targets in OG5_128162
Echinococcus multilocularis sphingosine kinase 1 Get druggable targets OG5_128162 All targets in OG5_128162
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0056 0.1431 0.1822
Brugia malayi Pre-SET motif family protein 0.0034 0.0719 0.0915
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0971 0.1218
Mycobacterium ulcerans hypothetical protein 0.0185 0.5479 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.036 0.5013
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.049 0.0281
Brugia malayi MAP kinase sur-1 0.0057 0.1465 0.1865
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.049 0.5
Schistosoma mansoni flap endonuclease-1 0.0026 0.0496 0.0904
Giardia lamblia PHD finger protein 15 0.0033 0.0694 0.0361
Entamoeba histolytica hypothetical protein, conserved 0.0185 0.5479 0.5317
Loa Loa (eye worm) hypothetical protein 0.0022 0.0346 0.044
Schistosoma mansoni polycystin 1-related 0.0022 0.036 0.0658
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0911 0.1663
Brugia malayi follicle stimulating hormone receptor 0.026 0.7855 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.1465 0.2039
Schistosoma mansoni jumonji domain containing protein 0.0085 0.2346 0.4282
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0971 0.1772
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.1792 0.2282
Schistosoma mansoni rab6-interacting 0.0022 0.036 0.0658
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0971 0.1236
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0911 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0134 0.0186
Onchocerca volvulus Alhambra homolog 0.0033 0.0694 0.0435
Loa Loa (eye worm) hypothetical protein 0.0022 0.036 0.0459
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0134 0.0186
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.2604 0.4399
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.036 0.0029
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.049 0.0281
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0911 0.1102
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.7024 0.8942
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0584 0.0744
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0971 0.1772
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.2604 0.4752
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0971 0.1218
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0584 0.0349
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1465 0.116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0328 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0346 0.0631
Plasmodium vivax SET domain protein, putative 0.0034 0.0719 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0719 0.0727
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0529 0.0358
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0694 0.0679
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.1465 0.1636
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0694 0.0884
Trypanosoma brucei hypothetical protein, conserved 0.0239 0.7187 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.036 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0039 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1811 0.2854
Onchocerca volvulus 0.0093 0.2604 0.2921
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1692 0.2623
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1692 0.2623
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1692 0.2623
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.1465 0.1636
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.1616 0.2474
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0529 0.0269
Schistosoma mansoni sphingosine kinase A B 0.0185 0.5479 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1465 0.1636
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0971 0.0648
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1811 0.2854
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0584 0.0465
Loa Loa (eye worm) hypothetical protein 0.0034 0.0719 0.0915
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1811 0.2854
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.049 0.6817
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0346 0.0481
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.1465 0.2181
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0584 0.0813
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.2604 0.3315
Echinococcus granulosus RUN 0.0022 0.036 0.0029
Schistosoma mansoni lipoxygenase 0.0022 0.036 0.0658
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.1692 0.2154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0719 0.1312
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0027 0.0529 0.019
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.036 0.0029
Plasmodium falciparum flap endonuclease 1 0.0029 0.0584 0.8414
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0971 0.1218
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1465 0.116
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.304 0.5249
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0971 0.0648
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.1465 0.1865
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1692 0.2623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0719 0.1312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 1 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0694 0.1267
Trypanosoma cruzi hypothetical protein, conserved 0.0239 0.7187 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0346 0.0481
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0134 0.0186
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0584 0.0247
Echinococcus granulosus flap endonuclease 1 0.0029 0.0584 0.0465
Brugia malayi Bromodomain containing protein 0.0033 0.0694 0.0884
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.1692 0.2623
Schistosoma mansoni hypothetical protein 0.0033 0.0694 0.1267
Brugia malayi jmjC domain containing protein 0.004 0.0911 0.116
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0529 0.0358
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0719 0.0727
Echinococcus granulosus peregrin 0.0033 0.0694 0.0679
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1811 1
Schistosoma mansoni sphingoid long chain base kinase 0.0185 0.5479 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0027 0.0529 0.0358
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.2604 0.4399
Mycobacterium tuberculosis Conserved protein 0.0185 0.5479 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0971 0.1218
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0694 0.3834
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0529 0.0269
Loa Loa (eye worm) hypothetical protein 0.0033 0.0694 0.0884
Treponema pallidum fructose-bisphosphate aldolase 0.0328 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.049 0.0682
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.1465 0.116
Mycobacterium ulcerans hypothetical protein 0.0027 0.0529 0.0358
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.1465 0.1636
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1811 0.2854
Brugia malayi Pre-SET motif family protein 0.0234 0.7024 0.8942
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0971 0.0648
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0694 0.0679
Brugia malayi Flap endonuclease-1 0.0029 0.0584 0.0744
Schistosoma mansoni DNA polymerase eta 0.0022 0.0346 0.0631
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.1692 0.3088
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1465 0.1636
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0346 0.0481
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0719 0.1312
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0346 0.044
Trypanosoma brucei unspecified product 0.0022 0.0346 0.0481
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0719 0.0727
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.036 0.0029
Schistosoma mansoni hypothetical protein 0.0022 0.036 0.0658
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0971 0.0914
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.1465 0.2181
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0971 0.1351
Plasmodium falciparum phd finger protein, putative 0.0033 0.0694 1
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0584 0.8125
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0346 0.044
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.1098 0.1466
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.016 0.4713 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.1465 0.1636
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0346 0.0481
Trypanosoma brucei protein kinase, putative 0.0057 0.1465 0.2039
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.1692 0.1968
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.1555 0.198
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0971 0.0914
Echinococcus multilocularis RUN 0.0022 0.036 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.036 0.0459
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1811 0.2854
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Echinococcus multilocularis sphingosine kinase 1 0.0185 0.5479 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 1 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.049 0.2706
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1811 0.3305
Mycobacterium tuberculosis Conserved protein 0.0027 0.0529 0.0358
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.1616 0.2474
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.1465 0.2674
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0584 0.3226
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0971 0.1218
Trypanosoma brucei unspecified product 0.0015 0.0134 0.0186
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.049 0.706
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1811 0.2854
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0719 0.397
Giardia lamblia Fructose-bisphosphate aldolase 0.0328 1 1
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0584 0.0247
Echinococcus multilocularis peregrin 0.0033 0.0694 0.0679
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0529 0.0358
Schistosoma mansoni lipoxygenase 0.0062 0.1616 0.2949
Onchocerca volvulus 0.0266 0.8041 1
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0529 0.0358
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0694 0.3834
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0971 0.0648
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0027 0.0529 0.0358
Trypanosoma brucei unspecified product 0.0015 0.0134 0.0186
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.049 0.0281
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.016 0.4713 0.8507
Loa Loa (eye worm) hypothetical protein 0.0093 0.2604 0.3315
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.016 0.4713 0.8507
Mycobacterium ulcerans hypothetical protein 0.0027 0.0529 0.0358
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1811 0.2141
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0346 0.0631
Brugia malayi PHD-finger family protein 0.0033 0.0694 0.0884
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.049 0.0211
Loa Loa (eye worm) follicle stimulating hormone receptor 0.026 0.7855 1
Echinococcus granulosus sphingosine kinase 1 0.0185 0.5479 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0529 0.0269
Echinococcus granulosus jumonji domain containing protein 0.0046 0.1098 0.1466
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1811 0.3305
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0694 0.9657
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0584 0.0247
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.068 0.0651
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0911 0.1663
Schistosoma mansoni loxhd1 0.0022 0.036 0.0658
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0971 0.1218
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.049 0.5
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.1465 0.2181
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0971 0.0648
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 1 1
Leishmania major hypothetical protein, conserved 0.0239 0.7187 1
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1465 0.116
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0039 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0346 0.044
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0911 0.1102
Entamoeba histolytica hypothetical protein 0.0026 0.049 0.015
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.036 0.5191
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1465 0.116
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.1465 0.2181
Loa Loa (eye worm) doublecortin family protein 0.0022 0.036 0.0459
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Loa Loa (eye worm) hypothetical protein 0.0042 0.0971 0.1236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0328 1 1
Trichomonas vaginalis set domain proteins, putative 0.0266 0.8041 0.7971
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.049 0.2706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0719 0.1312
Brugia malayi hypothetical protein 0.0022 0.036 0.0459
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0584 0.0349
Onchocerca volvulus 0.0034 0.0719 0.0467
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0346 0.0481
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.036 0.0029
Loa Loa (eye worm) hypothetical protein 0.0185 0.5479 0.6975
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.304 0.5249
Brugia malayi jmjC domain containing protein 0.0107 0.304 0.387
Schistosoma mansoni rab6-interacting 0.0022 0.036 0.0658
Brugia malayi hypothetical protein 0.0022 0.036 0.0459
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.1465 0.8092
Brugia malayi Doublecortin family protein 0.0022 0.036 0.0459
Trypanosoma cruzi hypothetical protein, conserved 0.0239 0.7187 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0971 0.0914
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.036 0.0029

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of sphingosine kinase 1 ChEMBL. 20598880

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.