TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 540.679 | Formula: C30H32N6O2S
H donors: 2 H acceptors: 4 LogP: 4.72 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1cnc(c(c1Nc1ccc2c(c1C)cc[nH]2)/C=C/c1ccc(cc1)CS(=O)(=O)N1CCN(CC1)C)C
InChi: 1S/C30H32N6O2S/c1-21-26-12-13-32-29(26)11-10-28(21)34-30-25(18-31)19-33-22(2)27(30)9-8-23-4-6-24(7-5-23)20-39(37,38)36-16-14-35(3)15-17-36/h4-13,19,32H,14-17,20H2,1-3H3,(H,33,34)/b9-8+
InChiKey: NIAJEEMQNUPFJB-CMDGGOBGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, theta	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, delta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0778	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0291	0.0752
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0778	1
Onchocerca volvulus		0.0026	0.0153	0.0251
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0153	0.0352
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0449	1
Brugia malayi	Inositol-1	0.0037	0.0291	0.0905
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.2702	0.8375
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0186	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0153	0.0352
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0186	0.0134
Loa Loa (eye worm)	inositol-1	0.0037	0.0291	0.0671
Mycobacterium ulcerans	glutaminase	0.027	0.3216	1
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0044	0.0378	0.0326
Echinococcus multilocularis	protein kinase c epsilon type	0.0044	0.0378	0.0326
Brugia malayi	Pleckstrin Homology Domain	0.0018	0.0053	0.0165
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0291	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0291	0.3282
Brugia malayi	RhoGAP domain containing protein	0.0018	0.0053	0.0165
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0026	0.0148	0.0342
Echinococcus multilocularis	tumor protein p63	0.0338	0.408	0.4049
Echinococcus multilocularis	protein kinase c iota type	0.0044	0.0378	0.0326
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0148	0.0096
Schistosoma mansoni	protein kinase C mu	0.0019	0.006	0.0007
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0148	0.0096
Loa Loa (eye worm)	glutaminase	0.027	0.3216	0.7408
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0148	0.0461
Brugia malayi	Probable ClpP-like protease	0.0076	0.0778	0.242
Brugia malayi	diacylglycerol kinase	0.0018	0.0053	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0291	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0238	0.2819	0.2781
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.2353	0.542
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0291	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0026	0.0148	0.0342
Brugia malayi	Hr1 repeat family protein	0.0026	0.0148	0.0461
Entamoeba histolytica	protein kinase, putative	0.0026	0.0148	0.3996
Brugia malayi	Pre-SET motif family protein	0.0029	0.0186	0.058
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0026	0.0148	0.0096
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0291	0.0752
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0025	0.0141	0.0278
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0026	0.0148	0.0096
Echinococcus granulosus	intermediate filament protein	0.0026	0.0153	0.01
Entamoeba histolytica	protein kinase, putative	0.0026	0.0148	0.3996
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0449	0.0398
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0019	0.006	0.0139
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0019	0.006	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4017	0.9252
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0778	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0778	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0449	0.4744
Echinococcus granulosus	lamin dm0	0.0026	0.0153	0.01
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0018	0.0053	0.0123
Loa Loa (eye worm)	glutaminase 2	0.027	0.3216	0.7408
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0018	0.0053	0.0123
Plasmodium vivax	SET domain protein, putative	0.0029	0.0186	0.1837
Brugia malayi	RhoGEF domain containing protein	0.0018	0.0053	0.0165
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0291	0.3282
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0148	0.0461
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0053	0.0000042455
Loa Loa (eye worm)	raf kinase	0.0018	0.0053	0.0123
Brugia malayi	Pre-SET motif family protein	0.0201	0.2353	0.7316
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0053	0.0000042455
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0026	0.0148	0.0096
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0242	0.477
Brugia malayi	p70 ribosomal S6 kinase beta	0.0026	0.0148	0.0461
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.0378	0.0326
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0291	0.0752
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0053	0.0166
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0291	0.0239
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0018	0.0053	0.0123
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0053	0.0002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0238	0.2819	0.2781
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0238	0.2819	0.6493
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.0378	0.0326
Schistosoma mansoni	ap endonuclease	0.0018	0.0053	0.0000042455
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0778	1
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Entamoeba histolytica	protein kinase, putative	0.0026	0.0148	0.3996
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.0053	0.0165
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0186	0.0134
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0778	0.1793
Echinococcus multilocularis	musashi	0.0026	0.0153	0.01
Toxoplasma gondii	hypothetical protein	0.0026	0.0153	0.137
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1029
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0148	0.0461
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0359	0.4342	1
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4017	0.9252
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0242	0.2864	0.6598
Echinococcus granulosus	protein kinase C gamma type	0.0026	0.0148	0.0096
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0291	0.0239
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0778	0.2292
Onchocerca volvulus		0.0029	0.0186	0.0336
Onchocerca volvulus		0.0229	0.2702	0.6684
Brugia malayi	intermediate filament protein	0.0026	0.0153	0.0475
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0019	0.006	0.0007
Schistosoma mansoni	microtubule-associated protein tau	0.0809	1	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0778	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Schistosoma mansoni	serine/threonine kinase	0.0026	0.0148	0.0096
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0173	0.0121
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0778	1
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0153	0.01
Toxoplasma gondii	exonuclease III APE	0.0018	0.0053	0.0001
Echinococcus granulosus	lamin	0.0026	0.0153	0.01
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Schistosoma mansoni	lamin	0.0026	0.0153	0.01
Echinococcus granulosus	protein kinase c epsilon type	0.0044	0.0378	0.0326
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0026	0.0148	0.0096
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0026	0.0148	0.0342
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0026	0.0148	0.0096
Onchocerca volvulus		0.005	0.0447	0.0993
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0238	0.2819	0.2781
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0238	0.2819	0.2781
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0026	0.0148	0.0096
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0778	0.0729
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0026	0.0148	0.0342
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0291	1
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0778	0.0729
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0053	0.5
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0291	1
Brugia malayi	glutaminase DH11.1	0.027	0.3216	1
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0148	0.0096
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0238	0.2819	0.2781
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0291	0.0239
Brugia malayi	RhoGAP domain containing protein	0.0018	0.0053	0.0165
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0778	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0186	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0449	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0242	0.1433
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0018	0.0053	0.0123
Echinococcus granulosus	tumor protein p63	0.0338	0.408	0.4049
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0447	0.0396
Echinococcus multilocularis	lamin	0.0026	0.0153	0.01
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0778	0.5
Loa Loa (eye worm)	hypothetical protein	0.0352	0.4246	0.9781
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0186	0.0134
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Echinococcus multilocularis	microtubule associated protein 2	0.0809	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.0378	0.0326
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0148	0.0096
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0186	0.0134
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0238	0.2819	0.2781
Brugia malayi	diacylglycerol kinase	0.0018	0.0053	0.0165
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0153	0.137
Toxoplasma gondii	AGC kinase	0.0026	0.0148	0.1312
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0153	0.137
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0026	0.0148	0.0342
Schistosoma mansoni	atypical protein kinase C	0.0044	0.0378	0.0326
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0026	0.0148	0.0096
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0026	0.0148	0.0096
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Echinococcus granulosus	protein kinase c iota type	0.0044	0.0378	0.0326
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0026	0.0148	0.0096
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0153	0.0352
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0449	1
Schistosoma mansoni	lamin	0.0026	0.0153	0.01
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0238	0.2819	0.2781
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0053	0.0123
Brugia malayi	follicle stimulating hormone receptor	0.0242	0.2864	0.8906
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0019	0.006	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0291	1
Echinococcus granulosus	NDR protein kinase	0.0026	0.0148	0.0096
Brugia malayi	protein kinase C3,putative	0.0019	0.006	0.0187
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0026	0.0148	0.0342
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0186	0.1837
Echinococcus multilocularis	lamin dm0	0.0026	0.0153	0.01
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0291	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0147	0.0338
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0148	0.0301
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0186	0.0134
Entamoeba histolytica	protein kinase, putative	0.0026	0.0148	0.3996
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0153	0.0475
Brugia malayi	C1-like domain containing protein	0.0019	0.006	0.0187
Onchocerca volvulus		0.0333	0.4017	1
Echinococcus granulosus	serine:threonine protein kinase N2	0.0026	0.0148	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0123
Trichomonas vaginalis	glutaminase, putative	0.027	0.3216	1
Brugia malayi	Protein kinase c protein 2	0.0019	0.006	0.0187
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0019	0.006	0.0139
Echinococcus multilocularis	serine threonine protein kinase	0.0026	0.0148	0.0096
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0778	0.5
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0153	0.137
Echinococcus granulosus	Protein kinase C brain isozyme	0.0044	0.0378	0.0326
Brugia malayi	protein kinase C II.	0.0044	0.0378	0.1175
Schistosoma mansoni	glutaminase	0.027	0.3216	0.318
Onchocerca volvulus		0.0026	0.0153	0.0251
Brugia malayi	Ras association domain family 1 isoform A	0.0018	0.0053	0.0165
Schistosoma mansoni	ap endonuclease	0.0018	0.0053	0.0000042455
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0778	0.2292
Brugia malayi	Protein kinase domain containing protein	0.0019	0.006	0.0187
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0044	0.0378	0.087
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0238	0.2819	0.8765
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4017	0.9252
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0186	0.0134
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0026	0.0148	0.3995
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0026	0.0148	0.0342

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.3 nM	Inhibition of PKCtheta	ChEMBL.	19854645
IC50 (binding)	= 110 nM	Inhibition of PKCdelta	ChEMBL.	19854645

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1079426

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1123210