Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0045 | 0.0771 | 0.195 |
Leishmania major | basic transcription factor 3a, putative | 0.0039 | 0.0501 | 0.9084 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0028 | 0.05 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.1876 | 0.1876 |
Brugia malayi | RNA binding protein | 0.007 | 0.1876 | 0.4748 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0028 | 0.0246 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.2977 | 0.2977 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0053 | 0.112 | 1 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0551 | 1 |
Onchocerca volvulus | 0.004 | 0.0551 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.2977 | 0.2977 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0551 | 1 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0045 | 0.0771 | 0.6879 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 0.0501 | 0.9084 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0028 | 0.05 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0551 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0551 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0551 | 0.0551 |
Brugia malayi | hypothetical protein | 0.004 | 0.058 | 0.1467 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0551 | 0.0551 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.2977 | 0.2977 |
Toxoplasma gondii | mitochondrial inner membrane translocase subunit TIM17, putative | 0.0045 | 0.0771 | 0.6879 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0039 | 0.0501 | 0.4329 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0255 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.2086 | 0.2086 |
Onchocerca volvulus | 0.004 | 0.0551 | 0.5 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0551 | 0.0551 |
Loa Loa (eye worm) | transport to inner mitochondrial membrane family member | 0.0053 | 0.112 | 0.112 |
Echinococcus multilocularis | transcription factor btf3 | 0.0039 | 0.0501 | 0.0501 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0551 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0551 | 0.0551 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0551 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.2977 | 0.7531 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0551 | 0.5 |
Toxoplasma gondii | TIM10 family protein, putative | 0.0053 | 0.112 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0551 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2086 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0551 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0551 | 0.0551 |
Brugia malayi | hypothetical protein | 0.0075 | 0.2086 | 0.5278 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0551 | 0.0551 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0551 | 0.1394 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0039 | 0.0501 | 0.9084 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.1876 | 0.1876 |
Toxoplasma gondii | NAC domain-containing protein | 0.0039 | 0.0501 | 0.4469 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0551 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0028 | 0.0246 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2086 | 1 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0045 | 0.0771 | 0.195 |
Brugia malayi | hypothetical protein | 0.004 | 0.058 | 0.1467 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.2977 | 0.2977 |
Schistosoma mansoni | mitochondrial import inner membrane translocase subunit tim10 | 0.0053 | 0.112 | 0.112 |
Echinococcus multilocularis | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0045 | 0.0771 | 0.0771 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2086 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0551 | 0.5 |
Echinococcus granulosus | transcription factor btf3 | 0.0039 | 0.0501 | 0.0501 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit TIM10 | 0.0053 | 0.112 | 0.2834 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.2086 | 0.2086 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2977 | 0.2977 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.2086 | 0.2086 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0255 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0771 | 0.0771 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0551 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Onchocerca volvulus | 0.004 | 0.0551 | 0.5 | |
Schistosoma mansoni | transcription factor btf3 | 0.0039 | 0.0501 | 0.0501 |
Toxoplasma gondii | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0053 | 0.112 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0551 | 1 |
Brugia malayi | beta-lactamase | 0.004 | 0.0551 | 0.1394 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2977 | 0.2977 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.2086 | 0.2086 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0551 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.2977 | 0.2977 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0551 | 0.4919 |
Loa Loa (eye worm) | ICD-1 protein | 0.0039 | 0.0501 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.1876 | 0.1876 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 0.0501 | 0.9084 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0551 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.1876 | 0.1876 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0551 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1876 | 0.1876 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM10, putative | 0.0053 | 0.112 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0254 | 0.9957 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0028 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0028 | 0.0028 |
Echinococcus granulosus | expressed protein | 0.0053 | 0.112 | 0.112 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2086 | 1 |
Brugia malayi | beta-NAC-like protein | 0.0039 | 0.0501 | 0.1266 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0045 | 0.0771 | 0.6801 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0045 | 0.0771 | 0.195 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0028 | 0.0246 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0551 | 0.1394 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0551 | 0.1394 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0771 | 0.0771 |
Brugia malayi | TAR-binding protein | 0.007 | 0.1876 | 0.4748 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0039 | 0.0501 | 0.4469 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0028 | 0.05 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0551 | 0.4791 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0028 | 0.05 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0255 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2977 | 0.2977 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0551 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.1876 | 0.4748 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.1876 | 0.1876 |
Brugia malayi | hypothetical protein | 0.0117 | 0.3952 | 1 |
Echinococcus multilocularis | expressed protein | 0.0053 | 0.112 | 0.112 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0551 | 0.0551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.