Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0555 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0052 | 0.0008 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0769 | 0.0758 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0555 | 1 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0555 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0769 | 0.0728 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0561 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0437 | 0.0425 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0561 | 0.0549 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0561 | 1 |
Onchocerca volvulus | 0.0555 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0818 | 0.0775 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.1658 | 0.162 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0769 | 0.0758 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0052 | 0.004 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0241 | 0.4272 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0052 | 0.0006 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0052 | 0.004 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.1067 | 0.1056 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0555 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1093 | 0.1082 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0094 | 0.0082 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0052 | 0.0008 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0437 | 0.0425 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0094 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0052 | 0.004 |
Echinococcus multilocularis | Mastin | 0.0555 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0052 | 0.004 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0052 | 0.0008 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0052 | 0.0008 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0555 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0052 | 0.004 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0769 | 0.0726 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0561 | 0.0519 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0052 | 0.0008 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0047 | 0.0034 |
Echinococcus granulosus | enteropeptidase | 0.0555 | 1 | 1 |
Onchocerca volvulus | 0.0052 | 0.0818 | 0.077 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0052 | 0.004 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0561 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0561 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0769 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0052 | 0.004 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0555 | 1 | 1 |
Onchocerca volvulus | 0.0555 | 1 | 1 | |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0052 | 0.004 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0052 | 0.0008 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0561 | 0.0519 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0437 | 0.0425 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0052 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0437 | 0.0392 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0555 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0006 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0052 | 0.0006 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0052 | 0.0006 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0561 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0052 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1093 | 0.1051 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0006 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0555 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0052 | 0.0008 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0052 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0006 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0052 | 0.0008 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0561 | 0.0517 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0435 | 0.0391 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0052 | 0.0008 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0437 | 0.0395 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0052 | 0.004 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0555 | 1 | 1 |
Echinococcus granulosus | Mastin | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.6246 | 0.6241 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0052 | 0.0006 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0769 | 0.0758 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.1658 | 0.162 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0561 | 0.0549 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0052 | 0.004 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0561 | 0.0517 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0052 | 0.004 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0555 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0561 | 0.3397 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0052 | 0.0008 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0052 | 0.004 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0468 | 0.0456 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0052 | 0.004 |
Mycobacterium ulcerans | hypothetical protein | 0.0555 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0555 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0052 | 0.004 |
Loa Loa (eye worm) | trypsin family protein | 0.0555 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0052 | 0.004 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0367 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0517 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0555 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0.0561 | 0.0511 | |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0052 | 0.004 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0052 | 0.004 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0555 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0052 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0006 |
Onchocerca volvulus | 0.0555 | 1 | 1 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0367 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0052 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0094 | 0.0082 |
Echinococcus multilocularis | tumor protein p63 | 0.0354 | 0.6335 | 0.6331 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0437 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0006 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0437 | 0.0425 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0437 | 0.0425 |
Onchocerca volvulus | 0.0555 | 1 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0561 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0561 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0555 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0561 | 0.0519 |
Onchocerca volvulus | 0.0555 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0017 | 0.0191 | 0.0148 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0769 | 0.0758 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0052 | 0.0008 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0555 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0769 | 0.0758 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0769 | 0.0758 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0052 | 0.0006 |
Onchocerca volvulus | 0.0038 | 0.0561 | 0.0511 | |
Echinococcus granulosus | tumor protein p63 | 0.0354 | 0.6335 | 0.6331 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0052 | 0.004 |
Brugia malayi | Trypsin family protein | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0052 | 0.0006 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0052 | 0.004 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0561 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0561 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0555 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0517 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0052 | 0.0008 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0468 | 0.0456 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Onchocerca volvulus | 0.0555 | 1 | 1 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0052 | 0.004 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0561 | 0.0549 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0052 | 0.0008 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0555 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0052 | 0.004 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0555 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0349 | 0.6246 | 0.6241 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0367 | 0.0324 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0437 | 0.0425 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0052 | 0.004 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0367 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0437 | 0.0425 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0468 | 0.0456 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.1658 | 0.1618 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0437 | 0.0425 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0052 | 0.0008 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0561 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.6246 | 0.6241 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0435 | 0.0393 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0437 | 0.0425 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0555 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0052 | 0.0008 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0437 | 0.0392 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0052 | 0.004 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0052 | 0.004 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.0939 | 1 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0561 | 0.0519 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0435 | 0.0424 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0047 | 0.0034 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0052 | 0.0008 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0561 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0052 | 0.0008 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0561 | 1 |
Onchocerca volvulus | 0.0038 | 0.0561 | 0.0511 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0561 | 0.0549 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0818 | 0.0807 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0.0435 | 0.0385 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0437 | 0.0395 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0052 | 0.004 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0052 | 0.0006 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0052 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.0555 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0561 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0555 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0052 | 0.0008 |
Echinococcus multilocularis | geminin | 0.0349 | 0.6246 | 0.6241 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1093 | 0.1053 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0006 |
Brugia malayi | hypothetical protein | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0517 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0052 | 0.004 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0052 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1658 | 0.1618 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0052 | 0.0008 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0468 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0561 | 0.0517 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Acceptor activity (binding) | = 64.2 | Electron acceptor activity on bovine milk xanthine oxidase using xanthine as reducing substrate | ChEMBL. | 15163191 |
Activity (functional) | Bactericidal activity against Mycobacterium tuberculosis H37Rv in GASTD medium at 2 times MIC after 30 days by colony counting | ChEMBL. | 21940166 | |
CC50 (ADMET) | > 100 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 21536434 |
IC50 (functional) | = 43 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 after 10 days by spectrophotometric analysis | ChEMBL. | 21940166 |
IC50 (functional) | = 43 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium after 10 days by spectrophotometric analysis | ChEMBL. | 21940166 |
IC50 (functional) | > 100 uM | Anticancer activity against human HL60 cells | ChEMBL. | 21536434 |
MIC90 (functional) | = 132 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 after 10 days by spectrophotometric analysis | ChEMBL. | 21940166 |
MIC90 (functional) | = 222 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium after 10 days by spectrophotometric analysis | ChEMBL. | 21940166 |
Ratio (functional) | = 1 | Ratio of MIC90 for Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 to MIC90 for Mycobacterium tuberculosis H37Rv in Fe-deficient GASTD medium | ChEMBL. | 21940166 |
Ratio IC50 (functional) | = 1 | Ratio of IC50 for Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 to IC50 for Mycobacterium tuberculosis H37Rv in Fe-deficient GASTD medium | ChEMBL. | 21940166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.