TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 299.391 | Formula: C16H17N3OS
H donors: 2 H acceptors: 2 LogP: 2.12 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: N#C[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccs1)N
InChi: 1S/C16H17N3OS/c17-11-13(9-12-5-2-1-3-6-12)19-16(20)15(18)10-14-7-4-8-21-14/h1-8,13,15H,9-10,18H2,(H,19,20)/t13-,15-/m0/s1
InChiKey: RIPMAEFOLLJUOL-ZFWWWQNUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin C	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	dipeptidyl aminopeptidase 2	Get druggable targets OG5_130494	All targets in OG5_130494
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Theileria parva	cathepsin C, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Cryptosporidium hominis	preprocathepsin c precursor	Get druggable targets OG5_130494	All targets in OG5_130494
Theileria parva	cathepsin C, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Babesia bovis	preprocathepsin c precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium falciparum	dipeptidyl aminopeptidase 1	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Get druggable targets OG5_130494	All targets in OG5_130494
Schistosoma japonicum	Cathepsin C precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Get druggable targets OG5_130494	All targets in OG5_130494
Toxoplasma gondii	preprocathepsin c precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Toxoplasma gondii	cathepsin CPC1	Get druggable targets OG5_130494	All targets in OG5_130494
Babesia bovis	cathepsin C precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Neospora caninum	hypothetical protein	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium knowlesi	dipeptidyl aminopeptidase 1, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium yoelii	cathepsin c precursor	Get druggable targets OG5_130494	All targets in OG5_130494
Giardia lamblia	Dipeptidyl-peptidase I precursor	Get druggable targets OG5_130494	All targets in OG5_130494
Cryptosporidium parvum	preprocathepsin c precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium yoelii	Homo sapiens P3ECSL-related	Get druggable targets OG5_130494	All targets in OG5_130494

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	cathepsin C	141 aa	152 aa	22.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0799	0.0799
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0277	0.0277
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0208	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0469
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0513	0.1798
Echinococcus granulosus	microtubule associated protein 2	0.0691	0.8497	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0277	0.0971
Toxoplasma gondii	exonuclease III APE	0.0018	0.0143	0.0514
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.1157	0.1362
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0482	0.0482
Toxoplasma gondii	preprocathepsin c precursor, putative	0.023	0.2773	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0087	0.0999	0.3601
Schistosoma mansoni	ap endonuclease	0.0018	0.0143	0.0168
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Brugia malayi	Pre-SET motif family protein	0.0029	0.0277	0.0971
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0277	0.0326
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0143	0.6843
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0482	0.0568
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0036	0.2517
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0128
Schistosoma mansoni	topbp1	0.001	0.0036	0.0042
Plasmodium vivax	SET domain protein, putative	0.0029	0.0277	0.0999
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0126
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.023	0.2773	1
Onchocerca volvulus		0.0029	0.0277	0.099
Brugia malayi	hypothetical protein	0.0237	0.2855	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0277	0.0326
Entamoeba histolytica	hypothetical protein	0.0071	0.0799	0.7023
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0208	0.073
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0143	0.0514
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.023	0.2773	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0208	0.073
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0557	0.1952
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0128
Brugia malayi	hypothetical protein	0.001	0.0036	0.0126
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0134	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0208	0.073
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0036	0.0128
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.2449	0.8579
Schistosoma mansoni	topbp1	0.001	0.0036	0.0042
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0482	0.0568
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0482	0.0568
Brugia malayi	hypothetical protein	0.001	0.0036	0.0126
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0036	0.0129
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0277	0.0326
Brugia malayi	CHE-14 protein	0.0042	0.0439	0.1538
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0208	0.073
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0036	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0128
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0134	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0469
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0143	0.0499
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0143	0.0509
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0208	0.183
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0277	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0237	0.2855	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0469
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0126
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0208	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0208	1
Echinococcus granulosus	nibrin	0.001	0.0036	0.0042
Brugia malayi	DKFZp564C0469 protein	0.001	0.0036	0.0126
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0087	0.0999	0.3601
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0087	0.0999	0.3517
Schistosoma mansoni	microtubule-associated protein tau	0.0691	0.8497	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0482	0.169
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0143	0.0143
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.023	0.2773	1
Onchocerca volvulus		0.0048	0.0513	0.1834
Toxoplasma gondii	cathepsin CPC2	0.0087	0.0999	0.3601
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0439	0.0517
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0439	0.1568
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0208	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0087	0.0999	0.3517
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.023	0.2773	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0482	0.169
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.5844
Entamoeba histolytica	hypothetical protein	0.0071	0.0799	0.7023
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0208	0.073
Echinococcus multilocularis	nibrin	0.001	0.0036	0.0036
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0208	0.183
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0208	1
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0036	0.0042
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0134	0.6421
Echinococcus granulosus	expressed conserved protein	0.0093	0.1064	0.1252
Schistosoma mansoni	patched 1	0.0042	0.0439	0.0517
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0126
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0036	0.0042
Schistosoma mansoni	DNA ligase IV	0.001	0.0036	0.0042
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0143	1
Entamoeba histolytica	hypothetical protein	0.001	0.0036	0.0315
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0208	1
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0208	1
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.2855	0.336
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0513	0.0513
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.2855	0.2855
Schistosoma mansoni	ap endonuclease	0.0018	0.0143	0.0168
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0277	0.0277
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0143	1
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0036	0.2517
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.023	0.2773	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0143	0.039
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0143	0.0509
Schistosoma mansoni	hypothetical protein	0.0048	0.0513	0.0604
Brugia malayi	topoisomerase	0.001	0.0036	0.0126
Echinococcus multilocularis	microtubule associated protein 2	0.0691	0.8497	0.8497
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0036	0.1722
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0482	0.0482
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.5844
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0134	0.6421
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0143	0.1253
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0208	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0143	0.0514
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.1138	0.3986
Giardia lamblia	Encystation-specific protease	0.0087	0.0999	0.3517
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0469
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0036	0.2517
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0143	0.6843
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0208	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.1138	0.1339
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0439	0.0439
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0208	0.073
Onchocerca volvulus		0.0024	0.0208	0.0744
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.1664	0.1664
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0208	1
Brugia malayi	Pre-SET motif family protein	0.0204	0.2449	0.8579
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0482	0.0568
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0143	0.6843
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.1138	0.1138
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0799	0.0941
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0143	1
Entamoeba histolytica	hypothetical protein	0.0071	0.0799	0.7023
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.2799	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0128
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0208	0.183
Toxoplasma gondii	cathepsin CPC1	0.023	0.2773	1
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0036	0.2517
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0143	0.0499
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0126
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0277	0.0999
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0126
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0036	0.0126
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0036	0.0036
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0036	0.0129
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.1664	0.1958
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0439	0.1538
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0143	0.0168
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0036	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0439	0.1538
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0208	1
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0036	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1138	0.3986
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0439	0.0517
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.1138	1
Entamoeba histolytica	hypothetical protein	0.0071	0.0799	0.7023
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0143	1
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0036	0.1722
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0277	0.0326
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0036	0.0129
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0208	1
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0513	0.0604
Onchocerca volvulus		0.0232	0.2799	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.023	0.2773	0.3264
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0482	0.0568
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0264	0.031
Brugia malayi	hypothetical protein	0.0071	0.0799	0.28
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0208	1
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0036	0.2517
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.5844
Echinococcus multilocularis	expressed conserved protein	0.0093	0.1064	0.1064
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0036	0.0315
Onchocerca volvulus		0.001	0.0036	0.0128
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0143	0.1688	0.603
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0208	1
Schistosoma mansoni	hypothetical protein	0.0071	0.0799	0.0941
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0143	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0208	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.5844
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0799	0.0941
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0036	0.0128
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0036	0.0128
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0134	0.0482
Echinococcus multilocularis	protein patched	0.0042	0.0439	0.0439
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0036	0.0128

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.9 nM	Inhibition of human recombinant cathepsin C	ChEMBL.	19665376

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1080780

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1132491