Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0152 | 0.0217 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.1583 | 0.226 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.1583 | 0.226 |
Echinococcus multilocularis | tumor protein p63 | 0.0248 | 0.5819 | 0.8308 |
Brugia malayi | MH2 domain containing protein | 0.0224 | 0.5191 | 0.7412 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0292 | 0.7004 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0307 | 0.0439 |
Entamoeba histolytica | hypothetical protein | 0.0068 | 0.1011 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.011 | 0.2154 | 0.3075 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3834 | 0.5475 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0307 | 0.0439 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.011 | 0.2154 | 0.3075 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0307 | 0.0439 |
Schistosoma mansoni | single-minded | 0.0036 | 0.016 | 0.0228 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0041 | 0.0307 | 0.0439 |
Onchocerca volvulus | 0.0234 | 0.5448 | 1 | |
Echinococcus multilocularis | geminin | 0.0124 | 0.2523 | 0.3603 |
Echinococcus granulosus | GPCR family 2 | 0.0041 | 0.0307 | 0.0439 |
Brugia malayi | thymidylate synthase | 0.0234 | 0.5448 | 0.7779 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0036 | 0.0176 | 0.0251 |
Leishmania major | pteridine reductase 1 | 0.0214 | 0.4926 | 0.4926 |
Brugia malayi | Dihydrofolate reductase | 0.0292 | 0.7004 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.013 | 0.2682 | 0.3829 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0606 | 0.0865 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0036 | 0.016 | 0.0228 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.013 | 0.2682 | 0.3829 |
Brugia malayi | hypothetical protein | 0.0111 | 0.2177 | 0.3108 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0404 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.0176 | 0.0045 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0404 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.013 | 0.2682 | 0.3829 |
Brugia malayi | PAS domain containing protein | 0.0036 | 0.016 | 0.0228 |
Loa Loa (eye worm) | thymidylate synthase | 0.0234 | 0.5448 | 0.7779 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0111 | 0.2177 | 0.2177 |
Echinococcus multilocularis | GPCR, family 2 | 0.0041 | 0.0307 | 0.0439 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0606 | 0.0865 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0068 | 0.1011 | 0.1444 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0173 | 0.3834 | 0.5475 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0307 | 0.0439 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0041 | 0.0307 | 0.0439 |
Brugia malayi | dihydrofolate reductase family protein | 0.0292 | 0.7004 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0068 | 0.1011 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0404 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0606 | 0.0865 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0404 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0248 | 0.5819 | 0.8308 |
Trypanosoma brucei | pteridine reductase 1 | 0.0211 | 0.4851 | 0.4851 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0089 | 0.1583 | 0.226 |
Echinococcus granulosus | dihydrofolate reductase | 0.0292 | 0.7004 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0292 | 0.7004 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0292 | 0.7004 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0224 | 0.5191 | 0.7412 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0606 | 0.0865 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0041 | 0.0307 | 0.0439 |
Brugia malayi | hypothetical protein | 0.0173 | 0.3834 | 0.5475 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.2682 | 0.3829 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0068 | 0.1011 | 0.1444 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0041 | 0.0307 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0176 | 0.0251 |
Schistosoma mansoni | survival motor neuron protein | 0.0035 | 0.0152 | 0.0217 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0292 | 0.7004 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0173 | 0.3834 | 0.5475 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0041 | 0.0307 | 0.0439 |
Brugia malayi | Cytochrome P450 family protein | 0.0041 | 0.0301 | 0.043 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0068 | 0.1011 | 0.1444 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0041 | 0.0307 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.2401 | 0.3428 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.2177 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0606 | 0.0865 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0292 | 0.7004 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0234 | 0.5448 | 0.7779 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0111 | 0.2177 | 0.3108 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0234 | 0.5448 | 0.7779 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0606 | 0.0865 |
Echinococcus granulosus | geminin | 0.0124 | 0.2523 | 0.3603 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0606 | 0.0865 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0041 | 0.0307 | 0.0439 |
Entamoeba histolytica | hypothetical protein | 0.0068 | 0.1011 | 0.5 |
Brugia malayi | hypothetical protein | 0.012 | 0.2401 | 0.3428 |
Echinococcus multilocularis | thymidylate synthase | 0.0234 | 0.5448 | 0.7779 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0224 | 0.5191 | 0.7412 |
Echinococcus granulosus | thymidylate synthase | 0.0234 | 0.5448 | 0.7779 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0307 | 0.0439 |
Brugia malayi | hypothetical protein | 0.0068 | 0.1011 | 0.1444 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2523 | 0.3603 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0404 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0041 | 0.0301 | 0.043 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0292 | 0.7004 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0606 | 0.0865 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1011 | 0.1444 |
Entamoeba histolytica | hypothetical protein | 0.0068 | 0.1011 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0035 | 0.0152 | 0.0217 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2523 | 0.3603 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0606 | 0.0865 |
Schistosoma mansoni | dihydrofolate reductase | 0.0292 | 0.7004 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 5.03 uM | Antiproliferative activity of compound was evaluated on SupT1 cells from human non-Hodgkin lymphoma | ChEMBL. | 11012027 |
ID50 (functional) | = 32.14 uM | Antiproliferative activity of compound was evaluated on Molt3 cells from human lymphoblastic leukemia | ChEMBL. | 11012027 |
ID50 (functional) | = 62.8 uM | Antiproliferative activity of compound was evaluated on MCF-7 cells from human breast adenocarcinoma | ChEMBL. | 11012027 |
ID50 (functional) | = 62.8 uM | Antiproliferative activity of compound was evaluated on MCF-7 cells from human breast adenocarcinoma | ChEMBL. | 11012027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.