Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.1003 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1003 | 0.7086 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0414 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0231 | 0.9169 | 0.9169 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0064 | 0.2143 | 0.2143 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.0414 | 0.0171 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0247 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0585 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0414 | 0.0414 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.1003 | 0.1003 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.4622 | 0.4622 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0247 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0585 | 0.0346 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0585 | 0.0585 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.0841 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1003 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0247 | 0.0206 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.1003 | 0.1003 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.0414 | 0.0414 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.1003 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0585 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0565 | 0.0565 |
Brugia malayi | Doublecortin family protein | 0.0023 | 0.0414 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3673 | 0.3673 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.0414 | 0.0171 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0023 | 0.0414 | 0.0414 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0023 | 0.0414 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0585 | 0.0585 |
Onchocerca volvulus | 0.0027 | 0.0585 | 0.0406 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0585 | 0.0585 |
Brugia malayi | Sodium/calcium exchanger protein | 0.01 | 0.3673 | 0.3966 |
Schistosoma mansoni | lipoxygenase | 0.0023 | 0.0414 | 0.0171 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.0414 | 0.0414 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0023 | 0.0414 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0044 | 0.1314 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.006 | 0.006 |
Loa Loa (eye worm) | doublecortin family protein | 0.0023 | 0.0414 | 0.0414 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0585 | 0.0585 |
Brugia malayi | follicle stimulating hormone receptor | 0.0231 | 0.9169 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1003 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.4905 | 0.4905 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0414 | 0.0171 |
Echinococcus granulosus | RUN | 0.0023 | 0.0414 | 0.0414 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.1003 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0585 | 0.0577 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.4905 | 0.4905 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.1003 | 0.7086 |
Schistosoma mansoni | sodium/calcium exchanger | 0.025 | 1 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0023 | 0.0414 | 0.0414 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0585 | 0.0585 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | solute carrier family 8 | 0.025 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0585 | 0.0585 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.0414 | 0.0414 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.4622 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0064 | 0.2143 | 0.1943 |
Brugia malayi | hypothetical protein | 0.0123 | 0.4622 | 0.5008 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1003 | 1 |
Onchocerca volvulus | 0.0027 | 0.0585 | 0.0406 | |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.1003 | 0.1003 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0064 | 0.2143 | 0.2143 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1003 | 0.7086 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0044 | 0.1314 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.0414 | 0.0414 |
Schistosoma mansoni | loxhd1 | 0.0023 | 0.0414 | 0.0171 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0247 | 0.0247 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0247 | 0.0247 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0414 | 0.0389 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.4622 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1003 | 0.0775 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.0841 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0414 | 0.0414 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.1003 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.4905 | 0.5319 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.4622 | 0.4622 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0247 | 0.0247 |
Brugia malayi | Inositol-1 | 0.0037 | 0.1003 | 0.1036 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1003 | 0.0775 |
Echinococcus multilocularis | sodium calcium exchanger | 0.025 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0585 | 0.0577 |
Echinococcus multilocularis | RUN | 0.0023 | 0.0414 | 0.0414 |
Schistosoma mansoni | polycystin 1-related | 0.0023 | 0.0414 | 0.0171 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1003 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.