Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutamate decarboxylase | 0.0023 | 0.0405 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1802 | 0.1802 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1585 | 0.1585 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Loa Loa (eye worm) | aromatic L-amino acid decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Echinococcus multilocularis | aromatic amino acid decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Brugia malayi | biogenic amine synthesis related protein 1 | 0.0023 | 0.0405 | 0.0405 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0177 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1802 | 0.1802 |
Brugia malayi | Pyridoxal-dependent decarboxylase conserved domain containing protein | 0.0023 | 0.0405 | 0.0405 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0177 | 0.0177 |
Trypanosoma cruzi | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0023 | 0.0405 | 0.0232 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0968 | 0.0968 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1585 | 0.1585 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0177 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1802 | 0.1802 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0968 | 0.0968 |
Brugia malayi | Aromatic-L-amino-acid decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1585 | 0.1585 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0177 | 0.5 |
Brugia malayi | glutamate decarboxylase, 67 kDa isoform | 0.0023 | 0.0405 | 0.0405 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0177 | 0.5 |
Brugia malayi | glutamate decarboxylase putative | 0.0023 | 0.0405 | 0.0405 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0023 | 0.0405 | 1 |
Mycobacterium tuberculosis | Probable glutamate decarboxylase GadB | 0.0023 | 0.0405 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0405 | 0.0405 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1585 | 0.1585 |
Trichomonas vaginalis | group II pyridoxal-5-phosphate decarboxylase, putative | 0.0023 | 0.0405 | 1 |
Entamoeba histolytica | s phingosine-1-phosphate lyase 1, putative | 0.02 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0177 | 0.5 |
Echinococcus granulosus | sphingosine 1 phosphate lyase 1 | 0.02 | 1 | 1 |
Leishmania major | sphingosine 1-phosphate lyase | 0.02 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1585 | 0.1585 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1585 | 0.1585 |
Loa Loa (eye worm) | TDC-1 protein | 0.0023 | 0.0405 | 0.0405 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0023 | 0.0405 | 0.0232 |
Echinococcus granulosus | pyridoxal dependent decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Echinococcus granulosus | aromatic amino acid decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0177 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1585 | 0.1585 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1802 | 0.1802 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.02 | 1 | 1 |
Echinococcus multilocularis | sphingosine 1 phosphate lyase 1 | 0.02 | 1 | 1 |
Trypanosoma brucei | sphingosine 1-phosphate lyase, putative | 0.02 | 1 | 1 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.02 | 1 | 1 |
Trypanosoma brucei | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0023 | 0.0405 | 0.0232 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1585 | 0.1585 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0.0405 | 0.0232 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0177 | 0.0177 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1585 | 0.1585 |
Trypanosoma cruzi | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0023 | 0.0405 | 0.0232 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | sphingosine-1-phosphate lyase 1 | 0.0023 | 0.0405 | 0.0405 |
Loa Loa (eye worm) | glutamate decarboxylase GAD1 | 0.0023 | 0.0405 | 0.0405 |
Schistosoma mansoni | sphingosine phosphate lyase | 0.02 | 1 | 1 |
Echinococcus multilocularis | pyridoxal dependent decarboxylase | 0.0023 | 0.0405 | 0.0405 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0177 | 0.0177 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.