Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Clostridium perfringens (strain 13 / Type A) | Microbial collagenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0037 | 0.0062 | 0.0062 |
Trichomonas vaginalis | G protein (olf) alpha subunit, gnal, putative | 0.0037 | 0.0062 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0044 | 0.0144 | 0.012 |
Schistosoma mansoni | Smad4 | 0.0044 | 0.0144 | 0.0144 |
Brugia malayi | MH2 domain containing protein | 0.0044 | 0.0144 | 0.012 |
Echinococcus multilocularis | guanine nucleotide binding protein subunit | 0.0037 | 0.0062 | 0.0039 |
Schistosoma mansoni | smad1 5 8 and | 0.0044 | 0.0144 | 0.0144 |
Schistosoma mansoni | GTP-binding protein alpha subunit | 0.0037 | 0.0062 | 0.0062 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0289 | 0.3068 | 0.3052 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0037 | 0.0062 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0113 | 0.097 | 0.5 |
Brugia malayi | hypothetical protein | 0.0073 | 0.049 | 0.0468 |
Schistosoma mansoni | GTP-binding protein (q) alpha-11 subunit gna11 | 0.0037 | 0.0062 | 0.0062 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0024 | 0.0024 |
Trichomonas vaginalis | GTP-binding protein (q) alpha-11 subunit, gna11, putative | 0.0037 | 0.0062 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0037 | 0.0062 | 0.0039 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0869 | 1 | 1 |
Trichomonas vaginalis | GTP-binding protein (z) alpha subunit, gnaz, putative | 0.0037 | 0.0062 | 0.5 |
Brugia malayi | guanine nucleotide-binding protein G-o protein alpha subunit | 0.0037 | 0.0062 | 0.0039 |
Echinococcus granulosus | tar DNA binding protein | 0.0326 | 0.3517 | 0.3501 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0113 | 0.097 | 0.5 |
Brugia malayi | Guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0037 | 0.0062 | 0.0039 |
Trichomonas vaginalis | GTP-binding protein (O) alpha subunit, gnao, putative | 0.0037 | 0.0062 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0113 | 0.097 | 0.5 |
Brugia malayi | N-terminal motif family protein | 0.0205 | 0.2072 | 0.2053 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0024 | 0.0024 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0326 | 0.3517 | 0.3501 |
Echinococcus multilocularis | guanine nucleotide binding protein subunit | 0.0037 | 0.0062 | 0.0039 |
Echinococcus granulosus | guanine nucleotide binding protein subunit | 0.0037 | 0.0062 | 0.0039 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0037 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.2072 | 0.2053 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0326 | 0.3517 | 0.3501 |
Brugia malayi | RNA binding protein | 0.0326 | 0.3517 | 0.3501 |
Loa Loa (eye worm) | G protein alpha subunit 3 | 0.0037 | 0.0062 | 0.0039 |
Schistosoma mansoni | GTP-binding protein alpha subunit | 0.0037 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0647 | 0.7355 | 0.7349 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0215 | 0.2188 | 0.217 |
Schistosoma mansoni | tar DNA-binding protein | 0.0326 | 0.3517 | 0.3517 |
Schistosoma mansoni | smad | 0.0044 | 0.0144 | 0.0144 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0869 | 1 | 1 |
Loa Loa (eye worm) | guanine nucleotide-binding protein alpha-12 subunit | 0.0037 | 0.0062 | 0.0039 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0044 | 0.0144 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0224 | 0.0224 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0113 | 0.097 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0326 | 0.3517 | 0.3501 |
Brugia malayi | MH2 domain containing protein | 0.0044 | 0.0144 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0062 | 0.0039 |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | 0.0037 | 0.0062 | 0.0062 |
Brugia malayi | MH1 domain containing protein | 0.0044 | 0.0144 | 0.012 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0869 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0024 | 0.0024 |
Schistosoma mansoni | smad1 5 8 and | 0.0044 | 0.0144 | 0.0144 |
Leishmania major | hypothetical protein, conserved | 0.0113 | 0.097 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0113 | 0.097 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | extracellular metallopeptidase | 0.0365 | 0.3981 | 0.5 |
Brugia malayi | Guanine nucleotide-binding protein alpha-6 subunit, putative | 0.0037 | 0.0062 | 0.0039 |
Schistosoma mansoni | tar DNA-binding protein | 0.0326 | 0.3517 | 0.3517 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0113 | 0.097 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0869 | 1 | 1 |
Brugia malayi | guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0037 | 0.0062 | 0.0039 |
Brugia malayi | guanine nucleotide-binding protein alpha-7 subunit, putative | 0.0037 | 0.0062 | 0.0039 |
Echinococcus granulosus | expressed protein | 0.0037 | 0.0062 | 0.0039 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0044 | 0.0144 | 0.012 |
Echinococcus multilocularis | expressed protein | 0.0037 | 0.0062 | 0.0039 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0044 | 0.0144 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0062 | 0.0039 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0215 | 0.2188 | 0.217 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0037 | 0.0062 | 0.5 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0037 | 0.0062 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0024 | 0.0024 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0869 | 1 | 1 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0037 | 0.0062 | 0.0062 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0205 | 0.2072 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0037 | 0.0062 | 0.0039 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0051 | 0.0224 | 0.02 |
Loa Loa (eye worm) | heterotrimeric G protein alpha subunit | 0.0037 | 0.0062 | 0.0039 |
Brugia malayi | guanine nucleotide-binding protein G(o), alpha subunit, putative | 0.0037 | 0.0062 | 0.0039 |
Brugia malayi | GTP-binding regulatory protein alpha chain - starfish, putative | 0.0037 | 0.0062 | 0.0039 |
Echinococcus multilocularis | smad | 0.0044 | 0.0144 | 0.012 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0108 | 0.0904 | 0.0882 |
Brugia malayi | Guanine nucleotide-binding protein alpha-12 subunit, putative | 0.0037 | 0.0062 | 0.0039 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0044 | 0.0144 | 0.012 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0108 | 0.0904 | 0.0882 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.0496 | 0.0496 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0869 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0647 | 0.7355 | 0.7349 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0062 | 0.0039 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0113 | 0.097 | 0.5 |
Echinococcus granulosus | gtp binding protein I alpha 1subunit | 0.0037 | 0.0062 | 0.0039 |
Brugia malayi | G-protein alpha subunit | 0.0037 | 0.0062 | 0.0039 |
Loa Loa (eye worm) | guanine nucleotide-binding protein alpha-6 subunit | 0.0037 | 0.0062 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.097 | 0.0949 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0037 | 0.0062 | 0.0062 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0062 | 0.0039 |
Brugia malayi | Smad1 | 0.0044 | 0.0144 | 0.012 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0044 | 0.0144 | 0.012 |
Brugia malayi | Guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0037 | 0.0062 | 0.0039 |
Schistosoma mansoni | trimeric G-protein alpha o subunit | 0.0037 | 0.0062 | 0.0062 |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | 0.0037 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0062 | 0.0039 |
Echinococcus granulosus | guanine nucleotide binding protein subunit | 0.0037 | 0.0062 | 0.0039 |
Echinococcus granulosus | smad | 0.0044 | 0.0144 | 0.012 |
Loa Loa (eye worm) | GTP-binding regulatory protein alpha chain | 0.0037 | 0.0062 | 0.0039 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0044 | 0.0144 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0496 | 0.0474 |
Schistosoma mansoni | GTP-binding protein (I) alpha subunit gnai | 0.0037 | 0.0062 | 0.0062 |
Schistosoma mansoni | tar DNA-binding protein | 0.0326 | 0.3517 | 0.3517 |
Echinococcus multilocularis | tar DNA binding protein | 0.0326 | 0.3517 | 0.3501 |
Echinococcus multilocularis | gtp binding protein (I) alpha 1subunit | 0.0037 | 0.0062 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0062 | 0.0039 |
Loa Loa (eye worm) | Smad1 | 0.0044 | 0.0144 | 0.012 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0869 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0326 | 0.3517 | 0.3501 |
Echinococcus granulosus | Smad4 | 0.0044 | 0.0144 | 0.012 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0869 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0037 | 0.0062 | 0.0039 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0051 | 0.0224 | 0.02 |
Schistosoma mansoni | GTP-binding protein (q) alpha-11 subunit gna11 | 0.0037 | 0.0062 | 0.0062 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0037 | 0.0062 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0326 | 0.3517 | 0.3501 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0037 | 0.0062 | 0.0062 |
Schistosoma mansoni | tar DNA-binding protein | 0.0326 | 0.3517 | 0.3517 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0044 | 0.0144 | 0.012 |
Brugia malayi | hypothetical protein | 0.0113 | 0.097 | 0.0949 |
Schistosoma mansoni | smad1 5 8 and | 0.0044 | 0.0144 | 0.0144 |
Brugia malayi | MH2 domain containing protein | 0.0647 | 0.7355 | 0.7349 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0037 | 0.0062 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.3068 | 0.3052 |
Schistosoma mansoni | tar DNA-binding protein | 0.0326 | 0.3517 | 0.3517 |
Brugia malayi | MH1 domain containing protein | 0.0044 | 0.0144 | 0.012 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0037 | 0.0062 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.0496 | 0.0474 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.