TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 315.161 | Formula: C16H11BrO2
H donors: 0 H acceptors: 1 LogP: 4.6 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc2cc(c3ccccc3)c(=O)oc2c(c1)Br
InChi: 1S/C16H11BrO2/c1-10-7-12-9-13(11-5-3-2-4-6-11)16(18)19-15(12)14(17)8-10/h2-9H,1H3
InChiKey: TYLXEMSZGAPZTD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	monoamine oxidase B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	Get druggable targets OG5_130722	All targets in OG5_130722
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	Get druggable targets OG5_130722	All targets in OG5_130722
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	Get druggable targets OG5_130722	All targets in OG5_130722

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	amine oxidase, flavin-containing family protein	monoamine oxidase B	520 aa	462 aa	19.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	aldehyde dehydrogenase	0.0132	0.1353	0.1685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0185	0.1107
Echinococcus multilocularis	geminin	0.0169	0.1756	0.2187
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0452	0.4839	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0026	0.0051
Schistosoma mansoni	ferritin	0.0009	0.0007	0.0009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0026	0.0157
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0022	0.0043
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0014	0.0063	0.0116
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0617	0.3701
Mycobacterium ulcerans	oxidoreductase	0.0025	0.0185	0.0367
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0026	0.0033
Schistosoma mansoni	apoferritin-2	0.0009	0.0007	0.0009
Plasmodium falciparum	glutathione reductase	0.0041	0.0354	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0026	0.0157
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0026	0.0051
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0025	0.0185	0.0367
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0014	0.0063	0.0116
Trichomonas vaginalis	glutathione reductase, putative	0.0014	0.0063	0.0056
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0447	0.2684
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0617	0.0768
Toxoplasma gondii	thioredoxin reductase	0.0041	0.0354	0.2256
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.036	0.0449
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0029	0.0227	0.1267
Mycobacterium ulcerans	dehydrogenase	0.0025	0.0185	0.0367
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0925	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0026	0.0033
Mycobacterium ulcerans	monoamine oxidase	0.0025	0.0185	0.0367
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0026	0.0033
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0026	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0157
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0925	1	1
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0029	0.0227	0.1267
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0132	0.1353	0.2785
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0617	0.3701
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0104	0.1038	0.2133
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0025	0.0185	0.4164
Schistosoma mansoni	microtubule-associated protein tau	0.0745	0.803	1
Schistosoma mansoni	serine/threonine protein kinase	0.0158	0.1637	0.2039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0026	0.0157
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0026	0.0033
Echinococcus multilocularis	flap endonuclease 1	0.0029	0.0227	0.0282
Mycobacterium tuberculosis	Probable dehydrogenase	0.0093	0.0925	0.1899
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0026	0.0033
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0022	0.0043
Schistosoma mansoni	flap endonuclease-1	0.0026	0.0196	0.0244
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0063	0.0079
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.036	0.0449
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0026	0.0033
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0925	1	1
Echinococcus multilocularis	tumor protein p63	0.0338	0.3592	0.4473
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0026	0.0033
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0026	0.0157
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0104	0.1038	0.2133
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0026	0.0033
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0025	0.0185	0.023
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0026	0.0033
Echinococcus multilocularis		0.0025	0.0185	0.023
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0026	0.0033
Plasmodium vivax	flap endonuclease 1, putative	0.0029	0.0227	0.5615
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1243	0.7457
Echinococcus granulosus	expressed protein	0.0009	0.0007	0.0009
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0025	0.0185	0.023
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0025	0.0185	1
Giardia lamblia	Flap structure-specific endonuclease	0.0029	0.0227	0.0164
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0132	0.1353	0.1685
Plasmodium falciparum	flap endonuclease 1	0.0029	0.0227	0.5615
Schistosoma mansoni	hypothetical protein	0.0169	0.1756	0.2187
Echinococcus granulosus	geminin	0.0169	0.1756	0.2187
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0026	0.0033
Schistosoma mansoni	amine oxidase	0.0025	0.0185	0.023
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0452	0.4839	1
Brugia malayi	RNA binding protein	0.0065	0.0617	0.1192
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0026	0.0051
Schistosoma mansoni	aldehyde dehydrogenase	0.0132	0.1353	0.1685
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0447	0.0557
Echinococcus granulosus	tumor protein p63	0.0338	0.3592	0.4473
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0447	0.0557
Schistosoma mansoni	ferritin	0.0009	0.0007	0.0009
Mycobacterium tuberculosis	Probable oxidoreductase	0.0104	0.1038	0.2133
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0026	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0157
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0041	0.0354	0.0718
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0026	0.0051
Onchocerca volvulus	Diphthamide biosynthesis protein 7 homolog	0.0148	0.1519	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0026	0.0033
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.0354	0.2125
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0447	0.0557
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0026	0.0051
Giardia lamblia	Fructose-bisphosphate aldolase	0.0925	1	1
Trypanosoma brucei	trypanothione reductase	0.0041	0.0354	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0132	0.1353	0.2785
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0925	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0132	0.1353	0.2785
Loa Loa (eye worm)	flap endonuclease-1	0.0029	0.0227	0.136
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0026	0.0051
Schistosoma mansoni	ferritin light chain	0.0009	0.0007	0.0009
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0026	0.0033
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0014	0.0063	0.0116
Brugia malayi	steroid hormone receptor	0.0011	0.0026	0.0051
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0333	0.3544	0.7321
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0448	0.2688
Toxoplasma gondii	histone lysine-specific demethylase	0.0025	0.0185	0.0939
Brugia malayi	amine oxidase, flavin-containing family protein	0.0025	0.0185	0.0356
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0925	1	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0104	0.1038	0.2133
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0185	0.1107
Schistosoma mansoni	amine oxidase	0.0025	0.0185	0.023
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0063	0.0122
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0025	0.0185	0.0367
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0093	0.0925	0.1899
Brugia malayi	Flap endonuclease-1	0.0029	0.0227	0.0438
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0026	0.0033
Plasmodium falciparum	protoporphyrinogen oxidase	0.0025	0.0185	0.4164
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0185	0.1107
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0026	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0157
Echinococcus granulosus	flap endonuclease 1	0.0029	0.0227	0.0282
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0025	0.0185	0.023
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0093	0.0925	0.1899
Echinococcus multilocularis	muscleblind protein	0.0161	0.1667	0.2076
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0026	0.0033
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0026	0.0033
Leishmania major	UDP-galactopyranose mutase	0.0025	0.0185	0.0939
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0026	0.0051
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0025	0.0185	0.4164
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0026	0.0033
Mycobacterium tuberculosis	Possible oxidoreductase	0.0025	0.0185	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0185	0.1107
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0448	0.0558
Brugia malayi	hypothetical protein	0.0025	0.0185	0.0356
Mycobacterium tuberculosis	Probable reductase	0.0093	0.0925	0.1899
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0157
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0026	0.0051
Schistosoma mansoni	hypothetical protein	0.0169	0.1756	0.2187
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0026	0.0051
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0359	0.382	0.7891
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0447	0.0557
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0026	0.0033
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0447	0.0557
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0093	0.0925	0.1899
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0026	0.0051
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.0354	1
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0026	0.0051
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0063	0.0079
Leishmania major	trypanothione reductase	0.0041	0.0354	0.2256
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0026	0.0033
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0132	0.1353	0.1685
Onchocerca volvulus		0.0025	0.0185	0.1061
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0025	0.0185	0.0939
Echinococcus multilocularis	Cyclin dependent kinase 2 associated protein	0.0148	0.1519	0.1891
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0063	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0925	1	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0025	0.0185	0.023
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1243	0.7457
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0452	0.4839	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0925	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0447	0.0557
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0025	0.0185	0.4164
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0026	0.0033
Brugia malayi	Muscleblind-like protein	0.0161	0.1667	0.3221
Plasmodium vivax	glutathione reductase, putative	0.0041	0.0354	1
Echinococcus multilocularis	muscleblind protein 1	0.0161	0.1667	0.2076
Treponema pallidum	fructose-bisphosphate aldolase	0.0925	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0026	0.0033
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0025	0.0185	0.0367
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0026	0.0033
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0026	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0157
Brugia malayi	Protein kinase domain containing protein	0.0158	0.1637	0.3163
Brugia malayi	glutathione reductase	0.0041	0.0354	0.0685
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0025	0.0185	0.023
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0026	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1519	0.911
Brugia malayi	SWIRM domain containing protein	0.0025	0.0185	0.0356
Echinococcus multilocularis	expressed protein	0.0009	0.0007	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0157
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0447	0.0557
Schistosoma mansoni	deleted in oral cancer 1/cdk2-associated protein-like	0.0148	0.1519	0.1891
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0158	0.1637	0.9822
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0185	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1667	1
Onchocerca volvulus		0.0049	0.0448	0.2827
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0617	0.1192
Toxoplasma gondii	aldehyde dehydrogenase	0.0132	0.1353	1
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0029	0.0227	0.5615
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.0354	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0026	0.0033
Echinococcus multilocularis	ferritin	0.0009	0.0007	0.0009
Brugia malayi	hypothetical protein	0.0483	0.5176	1
Schistosoma mansoni	ferritin	0.0009	0.0007	0.0009
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0617	0.0768
Plasmodium falciparum	thioredoxin reductase	0.0041	0.0354	1
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0617	0.3701
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0026	0.0051
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0093	0.0925	0.1899
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0093	0.0925	0.1899
Schistosoma mansoni	ferritin	0.0009	0.0007	0.0009
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0026	0.0033
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0617	0.0768
Schistosoma mansoni	coup transcription factor	0.0011	0.0026	0.0033
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0185	0.4164
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0925	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0617	0.0768
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0185	0.4164
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0026	0.0033
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0014	0.0063	0.0079
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0025	0.0185	0.4164
Echinococcus multilocularis	microtubule associated protein 2	0.0745	0.803	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0026	0.0033
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0026	0.0051
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0132	0.1353	0.2785
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0025	0.0185	0.4164
Treponema pallidum	NADH oxidase	0.0014	0.0063	0.0056
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0359	0.382	0.7891
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0617	0.0768
Trichomonas vaginalis	mercuric reductase, putative	0.0014	0.0063	0.0056
Loa Loa (eye worm)	glutathione reductase	0.0041	0.0354	0.2125
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0025	0.0185	0.4164
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0026	0.0157
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0617	0.0768
Schistosoma mansoni	apoferritin-2	0.0009	0.0007	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1667	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0063	1
Brugia malayi	TAR-binding protein	0.0065	0.0617	0.1192
Trichomonas vaginalis	flap endonuclease-1, putative	0.0029	0.0227	0.022
Brugia malayi	Thioredoxin reductase	0.0041	0.0354	0.0685
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0026	0.0157
Brugia malayi	MH2 domain containing protein	0.0122	0.1243	0.2402
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0026	0.0051
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0014	0.0063	0.0116
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0925	1	1
Echinococcus granulosus	muscleblind protein	0.0161	0.1667	0.2076
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0026	0.0051
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0025	0.0185	0.023
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0029	0.0227	0.5615
Brugia malayi	nuclear hormone receptor	0.0011	0.0026	0.0051
Echinococcus granulosus	microtubule associated protein 2	0.0745	0.803	1
Brugia malayi	ecdysteroid receptor	0.0011	0.0026	0.0051
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0132	0.1353	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0185	0.1107
Echinococcus granulosus	Cyclin dependent kinase 2 associated protein	0.0148	0.1519	0.1891
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0026	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0157
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0026	0.0157
Schistosoma mansoni	ferritin light chain	0.0009	0.0007	0.0009
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0447	0.0864
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0617	0.0768
Echinococcus granulosus	ferritin	0.0009	0.0007	0.0009
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0026	0.0051

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of MAOA expressed in BTI insect cells at 100 uM	ChEMBL.	20659799
IC50 (binding)	= 11.05 uM	Inhibition of human MAOB expressed in BTI insect cells	ChEMBL.	20659799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1221930

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1173175