Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0041 | 0.0082 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0041 | 0.0325 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.06 | 0.1106 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0321 | 0.2542 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.06 | 0.1106 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0179 | 0.3125 | 0.5763 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0512 | 0.0944 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.116 | 0.9175 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.06 | 0.1106 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.0637 | 0.1175 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0092 | 0.1433 | 0.2643 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0037 | 0.0361 | 0.2858 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.0321 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0184 | 0.0339 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.0037 | 0.0361 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.2667 | 0.4919 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0084 | 0.1264 | 0.4045 |
Mycobacterium tuberculosis | Conserved protein | 0.0084 | 0.1264 | 0.1264 |
Plasmodium vivax | hypothetical protein, conserved | 0.0084 | 0.1264 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0084 | 0.1264 | 0.1264 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.0637 | 0.0637 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0512 | 0.0944 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0179 | 0.3125 | 0.5763 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0082 | 0.0261 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0041 | 0.0076 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1433 | 0.2643 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0184 | 0.0339 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.0637 | 0.1175 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.1945 | 0.4448 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.116 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.06 | 0.1371 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0179 | 0.3125 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.116 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0156 | 0.2667 | 0.6099 |
Brugia malayi | beta-lactamase | 0.0084 | 0.1264 | 0.289 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0179 | 0.3125 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.116 | 0.2138 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.0165 | 0.1425 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0041 | 0.0325 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0084 | 0.1264 | 0.289 |
Onchocerca volvulus | 0.0084 | 0.1264 | 0.2003 | |
Schistosoma mansoni | ran | 0.0021 | 0.0041 | 0.0076 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.0637 | 0.4294 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0037 | 0.0361 | 0.0361 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0082 | 0.0162 |
Mycobacterium ulcerans | beta-lactamase | 0.0084 | 0.1264 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0084 | 0.1264 | 0.289 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0082 | 0.0261 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0082 | 0.0162 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0037 | 0.0361 | 0.0361 |
Brugia malayi | RNA, U transporter 1 | 0.0079 | 0.1182 | 0.2703 |
Onchocerca volvulus | 0.0092 | 0.1433 | 0.2363 | |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.0165 | 0.1308 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0321 | 0.0592 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0361 | 0.2858 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0512 | 0.117 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0084 | 0.1264 | 0.1264 |
Mycobacterium leprae | conserved hypothetical protein | 0.0084 | 0.1264 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.116 | 0.9175 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0041 | 0.0132 |
Plasmodium vivax | protease, putative | 0.0037 | 0.0361 | 0.2858 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1264 | 0.2331 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0037 | 0.0361 | 0.0361 |
Toxoplasma gondii | ABC1 family protein | 0.0084 | 0.1264 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.0165 | 0.1425 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.06 | 0.1106 |
Mycobacterium tuberculosis | Conserved protein | 0.0084 | 0.1264 | 0.1264 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0512 | 0.0944 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0179 | 0.3125 | 0.5763 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0156 | 0.2667 | 0.4919 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0184 | 0.1456 |
Schistosoma mansoni | ran | 0.0021 | 0.0041 | 0.0076 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.0637 | 0.0637 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.116 | 0.9175 |
Brugia malayi | Pre-SET motif family protein | 0.0244 | 0.4374 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.3125 | 0.5763 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.116 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0082 | 0.0162 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.1264 | 0.4045 |
Treponema pallidum | hypothetical protein | 0.0037 | 0.0361 | 0.3115 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0361 | 0.2858 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.116 | 0.9175 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0107 | 0.171 | 0.3911 |
Plasmodium falciparum | protease, putative | 0.0037 | 0.0361 | 0.3115 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0084 | 0.1264 | 0.2331 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1264 | 0.2331 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0084 | 0.1264 | 0.2331 |
Mycobacterium tuberculosis | Conserved protein | 0.0084 | 0.1264 | 0.1264 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0041 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1433 | 0.2643 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0084 | 0.1264 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0041 | 0.0132 |
Toxoplasma gondii | hypothetical protein | 0.0037 | 0.0361 | 0.2858 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0184 | 0.1587 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.116 | 0.2651 |
Entamoeba histolytica | CAAX amino terminal protease family | 0.0037 | 0.0361 | 0.1156 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.116 | 0.2138 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0084 | 0.1264 | 0.4045 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0084 | 0.1264 | 0.1264 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0084 | 0.1264 | 0.1264 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0184 | 0.0589 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.0321 | 0.0735 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0179 | 0.3125 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0084 | 0.1264 | 0.2331 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0084 | 0.1264 | 0.2331 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.2911 | 0.5368 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.0321 | 0.0592 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.5422 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0084 | 0.1264 | 0.2514 |
Onchocerca volvulus | 0.0086 | 0.1316 | 0.2115 | |
Echinococcus multilocularis | geminin | 0.0168 | 0.2911 | 0.5368 |
Toxoplasma gondii | hypothetical protein | 0.0037 | 0.0361 | 0.2858 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0179 | 0.3125 | 1 |
Brugia malayi | Trypsin family protein | 0.0092 | 0.1433 | 0.3277 |
Loa Loa (eye worm) | beta-lactamase | 0.0084 | 0.1264 | 0.2331 |
Onchocerca volvulus | 0.0277 | 0.5027 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0512 | 0.0944 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0512 | 0.0944 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0082 | 0.0261 |
Mycobacterium ulcerans | integral membrane protein | 0.0037 | 0.0361 | 0.2858 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0321 | 0.0592 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0084 | 0.1264 | 0.1264 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.06 | 0.1106 |
Onchocerca volvulus | 0.0084 | 0.1264 | 0.2003 | |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0084 | 0.1264 | 0.1264 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0084 | 0.1264 | 0.2514 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.06 | 0.1106 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0321 | 0.0592 |
Trichomonas vaginalis | esterase, putative | 0.0084 | 0.1264 | 0.2514 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1264 | 0.2331 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0512 | 0.0944 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.06 | 0.1106 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.116 | 0.2138 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.171 | 0.3154 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.06 | 0.1106 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1264 | 0.2331 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.06 | 0.1106 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0027 | 0.0165 | 0.1308 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.1945 | 0.3588 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1264 | 0.2331 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.1264 | 1 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0041 | 0.0132 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0041 | 0.0076 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.116 | 0.2138 |
Brugia malayi | beta-lactamase family protein | 0.0084 | 0.1264 | 0.289 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0092 | 0.1433 | 0.2643 |
Trichomonas vaginalis | set domain proteins, putative | 0.0277 | 0.5027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1264 | 0.2331 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.116 | 0.9051 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0084 | 0.1264 | 0.4045 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0041 | 0.0132 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0184 | 0.0589 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.1945 | 0.3588 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0084 | 0.1264 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0084 | 0.1264 | 0.2514 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0321 | 0.0592 |
Onchocerca volvulus | 0.0084 | 0.1264 | 0.2003 | |
Echinococcus granulosus | snurportin 1 | 0.0298 | 0.5422 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0084 | 0.1264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.171 | 0.3154 |
Echinococcus granulosus | geminin | 0.0168 | 0.2911 | 0.5368 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0084 | 0.1264 | 0.2514 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0184 | 0.0339 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0298 | 0.5422 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0244 | 0.4374 | 0.8066 |
Echinococcus multilocularis | snurportin 1 | 0.0298 | 0.5422 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.06 | 0.1106 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0035 | 0.0321 | 0.0592 |
Giardia lamblia | Hypothetical protein | 0.0179 | 0.3125 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.116 | 0.9175 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.06 | 0.1106 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0512 | 0.0944 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0179 | 0.3125 | 0.5763 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0184 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.2911 | 0.5368 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0041 | 0.0132 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0084 | 0.1264 | 0.2514 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0321 | 0.2542 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0034 | 0.0296 | 0.0546 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0041 | 0.0094 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.116 | 1 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0041 | 0.0355 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0041 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.06 | 0.1106 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0184 | 0.0421 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.06 | 0.1371 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0321 | 0.0592 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0084 | 0.1264 | 0.2331 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0179 | 0.3125 | 0.6215 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0084 | 0.1264 | 0.1264 |
Mycobacterium leprae | Probable lipase LipE | 0.0084 | 0.1264 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0512 | 0.0944 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0179 | 0.3125 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0156 | 0.2667 | 0.6099 |
Entamoeba histolytica | CAAX amino terminal protease family | 0.0037 | 0.0361 | 0.1156 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0184 | 0.1456 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0179 | 0.3125 | 0.7144 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.