Detailed information for compound 1179616

Basic information

Technical information
  • TDR Targets ID: 1179616
  • Name: 4-chloro-N,N'-dimethylbenzenecarboximidamide
  • MW: 182.65 | Formula: C9H11ClN2
  • H donors: 1 H acceptors: 0 LogP: 2.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN/C(=N\C)/c1ccc(cc1)Cl
  • InChi: 1S/C9H11ClN2/c1-11-9(12-2)7-3-5-8(10)6-4-7/h3-6H,1-2H3,(H,11,12)
  • InChiKey: NXTHBIFVICPVOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N,N'-dimethyl-benzamidine
  • 4-chloro-N,N'-dimethylbenzamidine
  • 4-chloro-N,N'-dimethyl-benzenecarboximidamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0171 0.0121
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0246 0.1155 0.1155
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0245 0.0457
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0102 0.0051
Echinococcus granulosus mixed lineage leukemia protein mll 0.0043 0.0102 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.0017
Brugia malayi hypothetical protein 0.0043 0.0102 0.0051
Schistosoma mansoni hypothetical protein 0.0078 0.0285 0.0276
Trypanosoma brucei glucosidase, putative 0.0036 0.0068 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0068 0.0017
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0171 0.0171
Mycobacterium tuberculosis Conserved protein 0.007 0.0245 0.0457
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0586 0.0537
Schistosoma mansoni alpha-glucosidase 0.014 0.0606 0.0597
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0051 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0083 0.0032
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0043 0.0102 0.0087
Brugia malayi latrophilin 2 splice variant baaae 0.0168 0.0752 0.0705
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0083 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0245 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0078 0.0285 0.0276
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0068 0.0233 0.0183
Loa Loa (eye worm) CXXC zinc finger family protein 0.0172 0.0769 0.0769
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0855 0.4299 1
Loa Loa (eye worm) beta-lactamase 0.007 0.0245 0.0245
Brugia malayi F/Y-rich N-terminus family protein 0.0052 0.0153 0.0102
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0068 0.0017
Mycobacterium ulcerans hypothetical protein 0.0855 0.4299 1
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0245 0.0195
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0171 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0083 0.0032
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0068 0.0068
Toxoplasma gondii histone lysine methyltransferase SET1 0.0325 0.1564 0.152
Echinococcus granulosus cpg binding protein 0.0182 0.082 0.0773
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0245 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.0032
Entamoeba histolytica hypothetical protein 0.0043 0.0102 0.0102
Brugia malayi beta-lactamase family protein 0.007 0.0245 0.0195
Schistosoma mansoni cpg binding protein 0.0172 0.0769 0.0761
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0043 0.0102 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.0586 0.0537
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0171 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0586 0.0577
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0068 0.0233 0.0428
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0068 0.0017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0171 0.0282
Echinococcus granulosus dnaJ subfamily B 0.0823 0.4138 0.4108
Schistosoma mansoni hypothetical protein 0.0823 0.4138 0.4133
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0171 0.0156
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0245 0.0195
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0068 0.0017
Schistosoma mansoni alpha glucosidase 0.0036 0.0068 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0083 0.0032
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0171 0.0121
Schistosoma mansoni hypothetical protein 0.0078 0.0285 0.0276
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0068 0.0017
Loa Loa (eye worm) hypothetical protein 0.0246 0.1155 0.1155
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0068 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0171 0.0171
Toxoplasma gondii exonuclease III APE 0.0056 0.0171 0.0121
Loa Loa (eye worm) hypothetical protein 0.0033 0.0051 0.0051
Trichomonas vaginalis helicase, putative 0.0039 0.0083 0.0032
Loa Loa (eye worm) hypothetical protein 0.0078 0.0285 0.0285
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.0233 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0586 0.0577
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0723 0.0675
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0245 0.0457
Toxoplasma gondii ABC1 family protein 0.007 0.0245 0.0195
Mycobacterium ulcerans lipase LipD 0.007 0.0245 0.0457
Echinococcus multilocularis GPCR, family 2 0.0078 0.0285 0.0269
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0723 0.0709
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0364 0.1765 0.1757
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0245 0.0457
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0171 0.0282
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0171 0.0121
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0723 0.0723
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0245 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0245 0.0245
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0171 0.0121
Loa Loa (eye worm) hypothetical protein 0.007 0.0245 0.0245
Brugia malayi CXXC zinc finger family protein 0.0172 0.0769 0.0722
Schistosoma mansoni pyruvate kinase 0.0033 0.0051 0.0042
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0068 0.0017
Schistosoma mansoni hypothetical protein 0.0168 0.0752 0.0744
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0245 0.0457
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0051 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0586 0.0571
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0285 0.0235
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0068 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0586 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.0032
Brugia malayi beta-lactamase family protein 0.007 0.0245 0.0195
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.0586 0.0586
Onchocerca volvulus 0.007 0.0245 0.2702
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0245 0.0237
Mycobacterium ulcerans beta-lactamase 0.007 0.0245 0.0457
Schistosoma mansoni pyruvate kinase 0.0033 0.0051 0.0042
Schistosoma mansoni ap endonuclease 0.0056 0.0171 0.0162
Trichomonas vaginalis esterase, putative 0.007 0.0245 0.0195
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0245 0.0457
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0285 0.0235
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0245 0.0195
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0245 0.023
Onchocerca volvulus 0.0094 0.0368 0.4414
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0246 0.1155 0.111
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0068 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0586 0.0577
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0171 0.0121
Echinococcus multilocularis pyruvate kinase 0.0033 0.0051 0.0036
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0245 0.0457
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.0233 0.0183
Loa Loa (eye worm) histone methyltransferase 0.0053 0.0156 0.0156
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0245 0.0457
Onchocerca volvulus 0.007 0.0245 0.2702
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.3406 0.34
Loa Loa (eye worm) hypothetical protein 0.007 0.0245 0.0245
Plasmodium vivax hypothetical protein, conserved 0.007 0.0245 0.0195
Echinococcus granulosus GPCR family 2 0.0078 0.0285 0.0235
Echinococcus multilocularis pyruvate kinase 0.0033 0.0051 0.0036
Brugia malayi beta-lactamase 0.007 0.0245 0.0195
Loa Loa (eye worm) hypothetical protein 0.0168 0.0752 0.0752
Entamoeba histolytica hypothetical protein 0.0043 0.0102 0.0102
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0068 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.0032
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.3406 0.3396
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0171 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0285 0.0269
Entamoeba histolytica hypothetical protein 0.0043 0.0102 0.0102
Mycobacterium ulcerans hypothetical protein 0.007 0.0245 0.0457
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0053 0.0156 0.0141
Schistosoma mansoni cpg binding protein 0.0182 0.082 0.0812
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0723 0.0709
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0068 0.0233 0.0224
Echinococcus granulosus geminin 0.0495 0.2443 0.2404
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0068 0.0017
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0068 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0083 0.0032
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0245 0.0195
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0102 0.0093
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0285 0.0235
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0083 0.0032
Echinococcus multilocularis dnaJ subfamily B 0.0823 0.4138 0.4129
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0245 0.0195
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0171 0.0121
Echinococcus granulosus microtubule associated protein 2 0.0682 0.3406 0.3372
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0102 0.0087
Schistosoma mansoni cpg binding protein 0.0182 0.082 0.0812
Schistosoma mansoni hypothetical protein 0.0043 0.0102 0.0093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0246 0.1155 0.111
Mycobacterium tuberculosis Conserved protein 0.007 0.0245 0.0457
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0171 0.0121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0586 0.0537
Entamoeba histolytica hypothetical protein 0.0043 0.0102 0.0102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0285 0.0285
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.0233 0.0428
Echinococcus multilocularis geminin 0.0495 0.2443 0.2431
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0245 0.0195
Schistosoma mansoni ap endonuclease 0.0056 0.0171 0.0162
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0068 0.0233 0.0183
Onchocerca volvulus 0.0172 0.0769 1
Chlamydia trachomatis pyruvate kinase 0.0033 0.0051 0.5
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0245 0.0457
Leishmania major hypothetical protein, conserved 0.007 0.0245 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0245 0.0245
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0245 0.0195
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0285 0.0269
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0285 0.0235
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0245 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.0032
Schistosoma mansoni hypothetical protein 0.0495 0.2443 0.2436
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0053 0.0156 0.0106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0102 0.0093
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0723 0.0675
Schistosoma mansoni alpha-glucosidase 0.014 0.0606 0.0597
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0245 0.0245
Echinococcus multilocularis cpg binding protein 0.0182 0.082 0.0806
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0068 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.0017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0083 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0068 0.0017
Schistosoma mansoni hypothetical protein 0.0495 0.2443 0.2436
Mycobacterium tuberculosis Conserved protein 0.007 0.0245 0.0457
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.021 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0068 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0083 0.0032
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0043 0.0102 0.0087
Schistosoma mansoni hypothetical protein 0.0078 0.0285 0.0276
Loa Loa (eye worm) hypothetical protein 0.007 0.0245 0.0245
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.0233 0.0428
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0245 0.0457
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0171 0.0121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0171 0.0121
Mycobacterium leprae Probable lipase LipE 0.007 0.0245 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0171 0.0121
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0449 0.2205 0.5071
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0068 0.0068
Onchocerca volvulus 0.007 0.0245 0.2702
Mycobacterium leprae conserved hypothetical protein 0.007 0.0245 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0083 0.0032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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