Detailed information for compound 1185348

Basic information

Technical information
  • TDR Targets ID: 1185348
  • Name: N-[6-(3,5-dichlorophenyl)-1H-indazol-3-yl]but anamide
  • MW: 348.227 | Formula: C17H15Cl2N3O
  • H donors: 2 H acceptors: 2 LogP: 4.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)Nc1n[nH]c2c1ccc(c2)c1cc(Cl)cc(c1)Cl
  • InChi: 1S/C17H15Cl2N3O/c1-2-3-16(23)20-17-14-5-4-10(8-15(14)21-22-17)11-6-12(18)9-13(19)7-11/h4-9H,2-3H2,1H3,(H2,20,21,22,23)
  • InChiKey: UOMYOKGRZMGKPR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[6-(3,5-dichlorophenyl)-1H-indazol-3-yl]butyramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.1446 0.5828
Echinococcus granulosus acetylcholinesterase 0.0067 0.2114 0.3112
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0918 0.1352
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0058 0.1729 0.2546
Loa Loa (eye worm) hypothetical protein 0.0067 0.2114 0.8658
Toxoplasma gondii exonuclease III APE 0.002 0.0072 0.0179
Loa Loa (eye worm) hypothetical protein 0.0039 0.0918 0.3589
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2198 0.3237
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0918 0.5312
Brugia malayi Carboxylesterase family protein 0.0067 0.2114 0.8697
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0918 0.5312
Brugia malayi TAR-binding protein 0.0069 0.2198 0.9045
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0918 0.0918
Plasmodium vivax glycogen synthase kinase 3, putative 0.0058 0.1729 1
Brugia malayi Carboxylesterase family protein 0.0067 0.2114 0.8697
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0072 0.0748
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.2198 0.9045
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.1446 0.8366
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.1374 0.5654
Mycobacterium ulcerans lipase LipD 0.0039 0.0918 0.9547
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0962 0.3958
Loa Loa (eye worm) inositol-1 0.004 0.0962 0.3774
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.1446 0.213
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.4282 0.4282
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0072 0.0106
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0962 0.1416
Brugia malayi Melibiase family protein 0.0074 0.243 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0072 0.0416
Brugia malayi beta-lactamase family protein 0.0039 0.0918 0.3779
Brugia malayi intracellular kinase 0.0058 0.1729 0.7114
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0072 0.0296
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.1729 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0072 0.0296
Loa Loa (eye worm) RNA binding protein 0.0069 0.2198 0.9016
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.4027 0.593
Mycobacterium tuberculosis Conserved protein 0.0039 0.0918 0.0918
Trichomonas vaginalis esterase, putative 0.0039 0.0918 0.3779
Mycobacterium tuberculosis Conserved protein 0.0039 0.0918 0.0918
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1374 0.2023
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2198 0.3237
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0918 0.3589
Schistosoma mansoni inositol monophosphatase 0.004 0.0962 0.1416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1374 0.2023
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.1729 0.7026
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0111 0.4027 0.593
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0058 0.1729 1
Brugia malayi Thioredoxin reductase 0.0051 0.1446 0.5952
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0918 0.0339
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0074 0.243 1
Mycobacterium tuberculosis Probable reductase 0.0117 0.4282 0.4282
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0918 0.3779
Mycobacterium ulcerans hypothetical protein 0.0039 0.0918 0.9547
Toxoplasma gondii ABC1 family protein 0.0039 0.0918 0.228
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0918 0.0918
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.4845 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0918 0.0918
Loa Loa (eye worm) beta-lactamase 0.0039 0.0918 0.3589
Loa Loa (eye worm) carboxylesterase 0.0067 0.2114 0.8658
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.4282 0.8614
Loa Loa (eye worm) hypothetical protein 0.0039 0.0918 0.3589
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0058 0.1729 0.2546
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0058 0.1729 0.4293
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0962 0.5564
Mycobacterium ulcerans beta-lactamase 0.0039 0.0918 0.9547
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0918 0.3779
Leishmania major trypanothione reductase 0.0051 0.1446 0.8366
Mycobacterium leprae Probable lipase LipE 0.0039 0.0918 0.0339
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0072 0.0416
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.4845 0.4845
Loa Loa (eye worm) hypothetical protein 0.0039 0.0918 0.3589
Schistosoma mansoni hypothetical protein 0.0176 0.6791 1
Plasmodium falciparum glutathione reductase 0.0051 0.1446 0.8366
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0962 0.3958
Loa Loa (eye worm) hypothetical protein 0.0039 0.0918 0.3589
Loa Loa (eye worm) hypothetical protein 0.0067 0.2114 0.8658
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0962 0.1416
Giardia lamblia Kinase, CMGC GSK 0.0058 0.1729 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0058 0.1729 1
Trypanosoma brucei trypanothione reductase 0.0051 0.1446 0.8366
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0918 0.1352
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0918 0.0918
Brugia malayi RNA binding protein 0.0069 0.2198 0.9045
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.4282 0.4282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1374 0.2023
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0962 0.5564
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0058 0.1729 0.2546
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0072 0.0106
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0072 1
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0962 0.3958
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0072 0.0416
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1374 0.2023
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.4027 0.593
Plasmodium vivax glutathione reductase, putative 0.0051 0.1446 0.8366
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0111 0.4027 0.593
Schistosoma mansoni ap endonuclease 0.002 0.0072 0.0106
Mycobacterium tuberculosis Conserved protein 0.0039 0.0918 0.0918
Trypanosoma brucei protein kinase, putative 0.0058 0.1729 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0918 0.3779
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0072 0.0416
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0918 0.1352
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.2198 0.9016
Schistosoma mansoni inositol monophosphatase 0.004 0.0962 0.1416
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0918 0.3779
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.1729 0.7114
Leishmania major hypothetical protein, conserved 0.0039 0.0918 0.5312
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.1446 0.213
Echinococcus multilocularis acetylcholinesterase 0.0067 0.2114 0.3112
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2198 0.3237
Plasmodium falciparum glycogen synthase kinase 3 0.0058 0.1729 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2198 0.3237
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0781 0.0781
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.243 0.3578
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1374 0.2023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1374 0.2023
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.4282 0.4282
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.4845 0.4845
Schistosoma mansoni ap endonuclease 0.002 0.0072 0.0106
Loa Loa (eye worm) acetylcholinesterase 1 0.0067 0.2114 0.8658
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.1374 0.5522
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0072 0.0748
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0962 0.5564
Loa Loa (eye worm) glutathione reductase 0.0051 0.1446 0.5828
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0918 0.0918
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.4027 0.593
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0918 0.9547
Brugia malayi beta-lactamase 0.0039 0.0918 0.3779
Brugia malayi beta-lactamase family protein 0.0039 0.0918 0.3779
Loa Loa (eye worm) hypothetical protein 0.0039 0.0918 0.3589
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0962 0.2388
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0111 0.4027 0.593
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0918 0.0918
Echinococcus granulosus geminin 0.0176 0.6791 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0918 0.1352
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0962 0.5564
Brugia malayi glutathione reductase 0.0051 0.1446 0.5952
Plasmodium falciparum thioredoxin reductase 0.0051 0.1446 0.8366
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.1446 0.8366
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.1446 0.1446
Brugia malayi Inositol-1 0.004 0.0962 0.3958
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2198 0.3237
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0918 0.3779
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0962 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0962 1
Echinococcus granulosus tar DNA binding protein 0.0069 0.2198 0.3237
Giardia lamblia Kinase, CMGC GSK 0.0058 0.1729 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0918 0.5312
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.243 0.3578
Echinococcus multilocularis acetylcholinesterase 0.0067 0.2114 0.3112
Loa Loa (eye worm) hypothetical protein 0.0039 0.0918 0.3589
Echinococcus granulosus protein kinase shaggy 0.0058 0.1729 0.2546
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0962 0.5371
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0918 0.5312
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0918 0.3779
Onchocerca volvulus 0.0058 0.1729 1
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.1729 0.7114
Echinococcus granulosus carboxylesterase 5A 0.0067 0.2114 0.3112
Echinococcus multilocularis carboxylesterase 5A 0.0067 0.2114 0.3112
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.4027 0.593
Echinococcus multilocularis geminin 0.0176 0.6791 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.2114 0.3112
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0072 0.0296
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.4282 0.4282
Echinococcus multilocularis protein kinase shaggy 0.0058 0.1729 0.2546
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0072 0.0416
Entamoeba histolytica protein kinase, putative 0.0058 0.1729 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1374 0.2023
Echinococcus granulosus acetylcholinesterase 0.0067 0.2114 0.3112
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0072 0.0416
Echinococcus multilocularis tar DNA binding protein 0.0069 0.2198 0.3237
Loa Loa (eye worm) hypothetical protein 0.0074 0.243 1
Loa Loa (eye worm) TAR-binding protein 0.0069 0.2198 0.9016
Toxoplasma gondii thioredoxin reductase 0.0051 0.1446 0.3591
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0072 0.0072
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0072 0.0416
Toxoplasma gondii melibiase subfamily protein 0.0111 0.4027 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.4845 0.4845
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.1729 0.7026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0918 0.9547
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0918 0.0918
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.1729 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.4282 0.4282
Schistosoma mansoni hypothetical protein 0.0176 0.6791 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.413 uM Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assay ChEMBL. 20167481

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.