TDR Targets

Basic information

Technical information

TDR Targets ID: 1191843
Name: ChemDiv2_001869
MW: 370.404 | Formula: C22H18N4O2
H donors: 0 H acceptors: 3 LogP: 3.77 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)c1nc2ccccc2n2c1c1n(C)c(=O)n(c(=O)c1c2)C
InChi: 1S/C22H18N4O2/c1-13-8-10-14(11-9-13)18-20-19-15(21(27)25(3)22(28)24(19)2)12-26(20)17-7-5-4-6-16(17)23-18/h4-12H,1-3H3
InChiKey: QMODGWYRAPYPLM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0144	0.2312	0.4619
Schistosoma mansoni	hypothetical protein	0.04	0.7048	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0085	0.1228	0.1212
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0087	0.1272	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0509	0.0492
Trichomonas vaginalis	glutaminase, putative	0.0289	0.4985	0.9606
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0077	0.0468
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0087	0.1272	0.2451
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0087	0.1272	0.2472
Leishmania major	phosphoinositide phosphatase	0.0185	0.3071	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1279	0.2439
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0077	0.0468
Leishmania major	hypothetical protein, conserved	0.0029	0.0187	0.0553
Onchocerca volvulus	Huntingtin homolog	0.0147	0.2378	0.5856
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0054	0.0658	0.2097
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1183	1
Echinococcus granulosus	L aminoadipate semialdehyde	0.0088	0.1279	0.1264
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0077	0.0116
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0124	0.1954	0.634
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0083	0.1183	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.509	0.9808
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0788	0.1095
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.3288	0.6323
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0077	0.0114
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0509	0.0699
Brugia malayi	MH2 domain containing protein	0.0139	0.2216	0.427
Trichomonas vaginalis	glucosylceramidase, putative	0.03	0.5189	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0025	0.0115	0.0346
Entamoeba histolytica	hypothetical protein	0.0085	0.1228	0.2386
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0077	0.0059
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0028	0.0184	0.0973
Echinococcus granulosus	geminin	0.04	0.7048	0.7043
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.03	0.5189	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0788	0.1095
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0085	0.1228	0.1212
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0187	0.1347
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.2216	0.425
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0788	0.2521
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0509	0.0492
Schistosoma mansoni	hypothetical protein	0.04	0.7048	1
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0025	0.0115	0.0318
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1183	0.2345
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0054	0.0658	0.2097
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0124	0.1954	0.1939
Brugia malayi	follicle stimulating hormone receptor	0.0284	0.4896	0.9434
Treponema pallidum	fructose-bisphosphate aldolase	0.0294	0.509	1
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0087	0.1269	0.2466
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0087	0.1272	0.2472
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0184	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1272	0.2425
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.2216	0.425
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpB	0.0185	0.3071	0.6146
Schistosoma mansoni	hypothetical protein	0.0085	0.1228	0.1721
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0124	0.1954	0.3897
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0284	0.4896	0.9432
Trichomonas vaginalis	glucosylceramidase, putative	0.0207	0.3483	0.6701
Trichomonas vaginalis	glucosylceramidase, putative	0.03	0.5189	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0054	0.0658	0.0641
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0509	0.0492
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.509	0.9808
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0294	0.509	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0509	0.0492
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0124	0.1954	0.3765
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0788	0.1549
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0509	0.095
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0087	0.1272	0.1784
Trichomonas vaginalis	glucosylceramidase, putative	0.03	0.5189	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0294	0.509	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1183	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1006	0.191
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.3288	0.6323
Onchocerca volvulus	Huntingtin homolog	0.0147	0.2378	0.5856
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0083	0.1183	0.1167
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0187	0.0996
Brugia malayi	Protein-tyrosine phosphatase	0.0083	0.1199	0.231
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0054	0.0658	0.2472
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.03	0.5189	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0788	0.0771
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0087	0.1272	0.1256
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1183	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0788	0.1549
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0088	0.1279	0.2465
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0116	0.1799	0.3444
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0115	0.0774
Brugia malayi	Probable ClpP-like protease	0.0083	0.1183	0.228
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0025	0.0115	0.0346
Toxoplasma gondii	hypothetical protein	0.0028	0.0184	0.0973
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0087	0.1272	0.2425
Trichomonas vaginalis	glucosylceramidase, putative	0.03	0.5189	1
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0115	0.0346
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.509	0.9808
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0087	0.1269	0.2466
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0077	0.0192
Schistosoma mansoni	ap endonuclease	0.0023	0.0077	0.0084
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0025	0.0115	0.0076
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0509	0.0699
Leishmania major	phosphopantetheinyl transferase-like protein	0.0025	0.0115	0.0318
Trichomonas vaginalis	conserved hypothetical protein	0.0185	0.3071	0.5904
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0187	0.0996
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0083	0.1183	0.4861
Mycobacterium ulcerans	glutaminase	0.0289	0.4985	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0187	0.1347
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0028	0.0184	0.0316
Trichomonas vaginalis	glucosylceramidase, putative	0.0207	0.3483	0.6701
Brugia malayi	hypothetical protein	0.0029	0.0187	0.036
Echinococcus multilocularis	ubiquitin specific protease 41	0.0087	0.1272	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1183	0.2253
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0144	0.2312	0.7515
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0087	0.1272	1
Trypanosoma cruzi	tyrosine phosphatase, putative	0.0053	0.0641	0.4967
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0087	0.1272	0.1256
Entamoeba histolytica	hypothetical protein, conserved	0.0053	0.0641	0.1228
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0509	0.0982
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0077	0.0118
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1183	0.2207
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.509	0.9808
Echinococcus granulosus	ubiquitin specific protease 41	0.0087	0.1272	0.1256
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase)	0.0185	0.3071	1
Schistosoma mansoni	ap endonuclease	0.0023	0.0077	0.0084
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0077	0.0148
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0124	0.1954	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1006	0.191
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0788	0.6426
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.3288	0.6323
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1269	0.2418
Entamoeba histolytica	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative	0.0053	0.0641	0.1228
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.3288	0.6323
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.509	0.9808
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0077	0.0114
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1183	0.2345
Brugia malayi	hypothetical protein	0.0085	0.1228	0.2367
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0294	0.509	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0187	0.0327
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0509	0.0699
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0788	0.0771
Echinococcus multilocularis	neuropeptide receptor A26	0.056	1	1
Echinococcus granulosus	peptidase Clp S14 family	0.0054	0.0658	0.0641
Echinococcus multilocularis	geminin	0.04	0.7048	0.7043
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0087	0.1272	1
Leishmania major	hypothetical protein, unknown function	0.0053	0.0641	0.204
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0077	0.0192
Echinococcus granulosus	neuropeptide receptor A26	0.056	1	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0087	0.1272	0.1784
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.509	0.9808
Echinococcus multilocularis	neuropeptide s receptor	0.056	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.03	0.5189	1
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0115	0.0346
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0083	0.1183	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0025	0.0115	0.0346
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0018	0.0035
Entamoeba histolytica	hypothetical protein	0.0025	0.0115	0.0191
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.3288	0.6323
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0083	0.1183	0.1167
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0144	0.2312	1
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0025	0.0115	0.0195
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0788	0.2521
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1006	0.191
Brugia malayi	hypothetical protein	0.0147	0.2378	0.4582
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.1272	0.2425
Trichomonas vaginalis	glucosylceramidase, putative	0.03	0.5189	1
Loa Loa (eye worm)	glutaminase	0.0289	0.4985	0.9606
Entamoeba histolytica	hypothetical protein	0.0085	0.1228	0.2386
Brugia malayi	glutaminase DH11.1	0.0289	0.4985	0.9607
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0124	0.1954	0.634
Onchocerca volvulus		0.0088	0.1279	0.0853
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0187	0.0996
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0087	0.1272	0.1256
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0187	0.0996
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0077	0.0059
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0184	0.0973
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0077	0.0468
Schistosoma mansoni	peptidase Clp (S14 family)	0.0083	0.1183	0.1657
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0077	0.0116
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.509	0.9808
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2378	0.4563
Onchocerca volvulus	Glucosylceramidase homolog	0.0197	0.3288	1
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0077	0.0114
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.3288	0.6323
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2378	0.4563
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0018	0.0035
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0087	0.1272	0.2425
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0124	0.1954	0.3897
Schistosoma mansoni	transcription factor LCR-F1	0.0085	0.1228	0.1721
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0088	0.1279	0.1264
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0788	0.1549
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0187	0.1347
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0087	0.1272	0.1256
Trichomonas vaginalis	glucosylceramidase, putative	0.0197	0.3288	0.6323
Entamoeba histolytica	hypothetical protein	0.0085	0.1228	0.2386
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0088	0.1279	0.1794
Entamoeba histolytica	hypothetical protein	0.0085	0.1228	0.2386
Schistosoma mansoni	glutaminase	0.0289	0.4985	0.7066
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0087	0.1272	0.4107
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.1183	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0083	0.1183	1
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0025	0.0115	0.0195
Loa Loa (eye worm)	glutaminase 2	0.0289	0.4985	0.9606
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.509	0.9808
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1112	0.2116
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0124	0.1954	0.2754

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	= 53 uM	Cytotoxicity against human cDDP-sensitive 2008 cells after 72 hrs using crystal violet staining by spectrophotometric analysis	ChEMBL.	20951595
Inhibition (binding)	< 5 %	Inhibition of human thymidylate synthase expressed in Escherichia coli BL21 at 50 uM	ChEMBL.	20951595

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1277139

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1191843