Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | arginine N-methyltransferase 1, putative | 0.0154 | 0.0816 | 0.5 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0154 | 0.0816 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0154 | 0.0816 | 0.5 |
Leishmania major | arginine N-methyltransferase, type I | 0.0154 | 0.0816 | 0.5 |
Echinococcus granulosus | methyltransferase protein 5 | 0.0154 | 0.0816 | 0.0816 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.076 | 0.076 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0154 | 0.0816 | 0.5 |
Brugia malayi | Protein arginine N-methyltransferase | 0.0154 | 0.0816 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0816 | 0.0816 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.076 | 0.076 |
Trypanosoma brucei | protein arginine n-methyltransferase 7 | 0.0154 | 0.0816 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0154 | 0.0816 | 0.5 |
Brugia malayi | hypothetical protein | 0.0154 | 0.0816 | 0.0816 |
Echinococcus multilocularis | protein arginine N methyltransferase 7 | 0.0154 | 0.0816 | 0.0816 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.0816 | 0.0816 |
Leishmania major | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 | 0.0154 | 0.0816 | 0.5 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0154 | 0.0816 | 0.5 |
Loa Loa (eye worm) | protein arginine N-methyltransferase | 0.0154 | 0.0816 | 0.0816 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.1709 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0154 | 0.0816 | 0.5 |
Onchocerca volvulus | 0.1555 | 0.9093 | 1 | |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.1709 | 1 | 1 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0154 | 0.0816 | 0.5 |
Loa Loa (eye worm) | Carm1-pending protein | 0.1709 | 1 | 1 |
Trypanosoma cruzi | arginine N-methyltransferase, type III | 0.0154 | 0.0816 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0154 | 0.0816 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0154 | 0.0816 | 0.5 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.1709 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.076 | 0.076 |
Trypanosoma cruzi | protein arginine n-methyltransferase 7 | 0.0154 | 0.0816 | 0.5 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0154 | 0.0816 | 0.5 |
Echinococcus granulosus | protein arginine N methyltransferase 7 | 0.0154 | 0.0816 | 0.0816 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.1709 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.1689 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.