Detailed information for compound 1232809

Basic information

Technical information
  • TDR Targets ID: 1232809
  • Name: (2R)-2-[4-[(2-bromo-4-nitrophenoxy)methyl]tri azol-1-yl]-2-phenylethanol
  • MW: 419.229 | Formula: C17H15BrN4O4
  • H donors: 1 H acceptors: 5 LogP: 2.66 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H](n1nnc(c1)COc1ccc(cc1Br)[N+](=O)[O-])c1ccccc1
  • InChi: 1S/C17H15BrN4O4/c18-15-8-14(22(24)25)6-7-17(15)26-11-13-9-21(20-19-13)16(10-23)12-4-2-1-3-5-12/h1-9,16,23H,10-11H2/t16-/m0/s1
  • InChiKey: WYUCFYDHCDGNJM-INIZCTEOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-2-[4-[(2-bromo-4-nitro-phenoxy)methyl]triazol-1-yl]-2-phenyl-ethanol
  • (2R)-2-[4-[(2-bromo-4-nitrophenoxy)methyl]-1-triazolyl]-2-phenylethanol
  • (2R)-2-[4-[(2-bromo-4-nitro-phenoxy)methyl]-1,2,3-triazol-1-yl]-2-phenyl-ethanol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei glucose transporter, putative 0.0033 0.0579 0.8593
Plasmodium vivax kinesin-5 0.0056 0.1097 0.1097
Leishmania major glucose transporter, lmgt3 0.0033 0.0579 0.8593
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0371 0.5503
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2231 0.2196
Onchocerca volvulus 0.0015 0.0173 0.5
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0674 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0579 0.8593
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.009 0.5
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0674 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0364 0.54
Onchocerca volvulus 0.0015 0.0173 0.5
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0364 0.0927
Plasmodium vivax hexose transporter 0.0106 0.2231 0.2231
Brugia malayi Cam kinase protein 1 0.0032 0.057 0.2553
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0579 0.1973
Trypanosoma brucei glucose transporter, putative 0.0033 0.0579 0.8593
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0579 0.8593
Schistosoma mansoni sugar transporter 0.0015 0.0173 0.0209
Toxoplasma gondii protein kinase, putative 0.0299 0.6602 1
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0173 0.0262
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0371 0.0371
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0555 0.5055
Toxoplasma gondii kinesin motor domain-containing protein 0.0056 0.1097 0.1662
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Brugia malayi Sugar transporter family protein 0.0015 0.0173 0.0775
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0555 0.0407
Echinococcus granulosus dna polymerase eta 0.0023 0.0364 0.0204
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0173 0.0775
Leishmania major DNA polymerase kappa, putative 0.0023 0.0364 0.54
Schistosoma mansoni hypothetical protein 0.0106 0.2231 0.2694
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0364 0.54
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2231 0.2196
Echinococcus granulosus kinesin family 1 0.0429 0.9543 1
Entamoeba histolytica kinesin, putative 0.0056 0.1097 1
Loa Loa (eye worm) sugar transporter 0.0106 0.2231 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0674 1
Plasmodium falciparum protein kinase 7 0.0299 0.6602 0.6602
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0674 0.0674
Brugia malayi Kinesin motor domain containing protein 0.0056 0.1097 0.4918
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.057 0.0423
Brugia malayi hypothetical protein 0.0015 0.0173 0.0775
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0371 0.3379
Toxoplasma gondii sugar transporter ST3 0.0015 0.0173 0.0262
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.057 0.0423
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0173 0.2567
Echinococcus granulosus geminin 0.0205 0.4468 0.4584
Schistosoma mansoni glucose transport protein 0.0106 0.2231 0.2694
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Echinococcus multilocularis geminin 0.0205 0.4468 0.4584
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Echinococcus multilocularis kinesin family 1 0.0429 0.9543 1
Trypanosoma brucei sugar transporter, putative 0.0015 0.0173 0.2567
Schistosoma mansoni hypothetical protein 0.0373 0.8282 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0579 0.1973
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0173 0.4665
Toxoplasma gondii sugar transporter ST2 0.0015 0.0173 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.057 0.2553
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0524 0.0375
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0173 0.2567
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0173 0.5
Loa Loa (eye worm) sugar transporter 0.0015 0.0173 0.0775
Trypanosoma brucei unspecified product 0.0016 0.02 0.297
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Brugia malayi hypothetical protein 0.0015 0.0173 0.0775
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0173 0.2567
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2231 0.2196
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0364 0.0204
Schistosoma mansoni sugar transporter 0.0015 0.0173 0.0209
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0364 0.1631
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0173 0.0775
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.057 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0371 0.0371
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.057 0.057
Onchocerca volvulus 0.0015 0.0173 0.5
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0579 0.1973
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0555 0.0407
Brugia malayi Sugar transporter family protein 0.0106 0.2231 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.02 0.297
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.057 0.0863
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.057 0.1927
Brugia malayi major facilitator superfamily protein 0.0015 0.0173 0.0775
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.057 0.0423
Leishmania major protein kinase, putative 0.0032 0.057 0.8453
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.057 0.0423
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0555 0.067
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0173 0.2567
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.057 0.8453
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0173 0.4665
Loa Loa (eye worm) hypothetical protein 0.0026 0.042 0.1882
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0579 0.1973
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0364 0.54
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0371 0.5503
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0173 0.4665
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Schistosoma mansoni sugar transporter 0.0015 0.0173 0.0209
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0364 0.0204
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0579 0.8593
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0371 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0364 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0371 0.3046
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.057 0.0423
Loa Loa (eye worm) kinesin-like protein KLP2 0.0056 0.1097 0.4918
Schistosoma mansoni glucose transport protein 0.0106 0.2231 0.2694
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0371 0.0211
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0242 0.3595
Trypanosoma brucei unspecified product 0.0023 0.0364 0.54
Plasmodium vivax sugar transporter, putative 0.0015 0.0173 0.0173
Echinococcus multilocularis General substrate transporter 0.0091 0.1894 0.1837
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0371 0.1662
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0555 1
Trypanosoma cruzi hexose transporter 0.0033 0.0579 0.8593
Trypanosoma brucei glucose transporter, putative 0.0033 0.0579 0.8593
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0173 0.0209
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2231 0.2196
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Onchocerca volvulus 0.0015 0.0173 0.5
Schistosoma mansoni hypothetical protein 0.0205 0.4468 0.5395
Giardia lamblia Hexose transporter 0.0015 0.0173 0.1576
Schistosoma mansoni DNA polymerase eta 0.0023 0.0364 0.0439
Trypanosoma brucei glucose transporter 1E 0.0033 0.0579 0.8593
Schistosoma mansoni sugar transporter 0.0015 0.0173 0.0209
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0555 0.2486
Schistosoma mansoni protein kinase 0.0032 0.057 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Giardia lamblia Kinesin-5 0.0056 0.1097 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0364 0.54
Plasmodium vivax CDK-related protein kinase 6, putative 0.0449 1 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Schistosoma mansoni glucose transport protein 0.0106 0.2231 0.2694
Brugia malayi Sugar transporter family protein 0.0015 0.0173 0.0775
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0579 0.8593
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0674 0.0674
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2231 0.2196
Leishmania major glucose transporter, lmgt1 0.0033 0.0579 0.8593
Onchocerca volvulus 0.0015 0.0173 0.5
Entamoeba histolytica hypothetical protein 0.0024 0.0371 0.0095
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0371 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0364 0.54
Echinococcus granulosus dna polymerase kappa 0.0023 0.0364 0.0204
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.057 0.0423
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0579 0.8593
Trypanosoma brucei glucose transporter, putative 0.0033 0.0579 0.8593
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0173 0.0775
Schistosoma mansoni glucose transporter 0.0015 0.0173 0.0209
Loa Loa (eye worm) hypothetical protein 0.0032 0.057 0.2553
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0364 0.0927
Giardia lamblia Sugar-proton symporter 0.0015 0.0173 0.1576
Onchocerca volvulus 0.0015 0.0173 0.5
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0371 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0674 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0579 0.8593
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.02 0.297
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.057 0.057
Brugia malayi hypothetical protein 0.0015 0.0173 0.0775
Entamoeba histolytica protein kinase, putative 0.0032 0.057 0.2805
Loa Loa (eye worm) hypothetical protein 0.0032 0.0555 0.2486
Trypanosoma brucei glucose transporter, putative 0.0033 0.0579 0.8593
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0364 0.54
Schistosoma mansoni protein kinase 0.0032 0.057 0.0688
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0364 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.057 0.057
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0579 0.8593
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.057 0.2553
Onchocerca volvulus 0.0015 0.0173 0.5
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0364 0.0204
Onchocerca volvulus 0.0015 0.0173 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0364 0.54
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.057 0.0863
Onchocerca volvulus Putative transporter 0.0015 0.0173 0.5
Onchocerca volvulus 0.0015 0.0173 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0364 0.1631
Onchocerca volvulus 0.0015 0.0173 0.5
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0579 0.1973
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0364 0.1631
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.029 0.6143
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2231 0.3379
Schistosoma mansoni protein kinase 0.0032 0.057 0.0688
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0371 0.5503
Mycobacterium ulcerans sugar transporter 0.0015 0.0173 0.4665
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0173 0.0775
Schistosoma mansoni hypothetical protein 0.0205 0.4468 0.5395
Plasmodium falciparum hexose transporter 0.0106 0.2231 0.2231
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.009 0.2428
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2231 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0674 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0371 0.0211
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0524 0.0375
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0555 0.2486
Plasmodium falciparum kinesin-5 0.0056 0.1097 0.1097
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0555 0.1855
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0364 0.1631
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.3706 0.3706
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0371 0.0961
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0173 0.0775
Toxoplasma gondii sugar transporter ST1 0.0015 0.0173 0.0262
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0364 0.54
Giardia lamblia DINP protein human, muc B family 0.0023 0.0364 0.3316
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.3706 0.3706
Loa Loa (eye worm) hypothetical protein 0.0024 0.0371 0.1662
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0364 0.9812
Schistosoma mansoni kinesin eg-5 0.0056 0.1097 0.1325
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.057 0.0863
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0364 0.54
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.02 0.297
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.3706 0.5613
Trypanosoma brucei glucose transporter, putative 0.0033 0.0579 0.8593
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Echinococcus granulosus General substrate transporter 0.0091 0.1894 0.1837
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.057 0.2553
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.057 0.0423
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2231 0.2196
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2231 0.2196
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.057 0.0423
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0364 0.0439
Onchocerca volvulus 0.0015 0.0173 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0364 0.0439
Trypanosoma brucei glucose transporter, putative 0.0033 0.0579 0.8593
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0555 0.2603
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0305 0.0641
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0371 0.0448
Onchocerca volvulus 0.0015 0.0173 0.5
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0579 0.1973
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0775
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0555 0.2486
Leishmania major hypothetical protein, conserved 0.0015 0.0173 0.2567
Leishmania major DNA polymerase eta, putative 0.0023 0.0364 0.54
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Trypanosoma brucei glucose transporter 2A 0.0033 0.0579 0.8593
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.057 0.057
Entamoeba histolytica protein kinase, putative 0.0032 0.057 0.2805
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0364 0.54
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2231 0.2196
Onchocerca volvulus 0.0015 0.0173 0.5
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0579 0.1973
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0173 0.2567
Echinococcus multilocularis dna polymerase eta 0.0023 0.0364 0.0204
Leishmania major glucose transporter, lmgt2 0.0033 0.0579 0.8593
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.54
Onchocerca volvulus 0.0015 0.0173 0.5
Onchocerca volvulus 0.0015 0.0173 0.5
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.057 0.057
Trypanosoma brucei unspecified product 0.0016 0.02 0.297
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0674 0.102
Onchocerca volvulus 0.0015 0.0173 0.5
Brugia malayi major facilitator superfamily protein 0.0015 0.0173 0.0775
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.057 0.057
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0555 0.067
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0131 0.0588
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0371 0.0448
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0364 0.9812
Trypanosoma brucei glucose transporter, putative 0.0033 0.0579 0.8593
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.029 0.6143
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0371 0.0562

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 2.9093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 22.3872 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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