Detailed information for compound 1234069

Basic information

Technical information
  • TDR Targets ID: 1234069
  • Name: 3-[4-(4-chlorophenyl)-5-methyl-1,3-thiazol-2- yl]-7-phenyl-1,6,7,8-tetrahydroquinoline-2,5- dione
  • MW: 446.949 | Formula: C25H19ClN2O2S
  • H donors: 1 H acceptors: 3 LogP: 4.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1nc(sc1C)c1cc2C(=O)CC(Cc2[nH]c1=O)c1ccccc1
  • InChi: 1S/C25H19ClN2O2S/c1-14-23(16-7-9-18(26)10-8-16)28-25(31-14)20-13-19-21(27-24(20)30)11-17(12-22(19)29)15-5-3-2-4-6-15/h2-10,13,17H,11-12H2,1H3,(H,27,30)
  • InChiKey: KZGSVGACIURFJC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-(4-chlorophenyl)-5-methyl-thiazol-2-yl]-7-phenyl-1,6,7,8-tetrahydroquinoline-2,5-dione
  • 3-[4-(4-chlorophenyl)-5-methyl-2-thiazolyl]-7-phenyl-1,6,7,8-tetrahydroquinoline-2,5-dione
  • 3-[4-(4-chlorophenyl)-5-methyl-thiazol-2-yl]-7-phenyl-1,6,7,8-tetrahydroquinoline-2,5-quinone
  • C202-3199
  • NCGC00105416-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0377
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1495 0.1977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0365 0.0482
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0569 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0832 0.0936
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0925 0.104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0832 0.0832
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0072 0.1382 0.1382
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.3081 0.3464
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0752
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0228 0.5376 0.6044
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0377
Loa Loa (eye worm) RNA binding protein 0.0076 0.1495 0.1681
Giardia lamblia GTOR 0.0054 0.0925 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0832 0.0832
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0925 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1495 0.1681
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0832 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0752
Loa Loa (eye worm) hypothetical protein 0.0228 0.5376 0.6044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0847
Schistosoma mansoni hypothetical protein 0.0043 0.0648 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0284 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0847
Schistosoma mansoni glutaminase 0.0313 0.7564 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0925 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0925 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0648 0.0856
Loa Loa (eye worm) hypothetical protein 0.0072 0.1382 0.1554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0925 0.1223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0925 0.104
Brugia malayi Calcitonin receptor-like protein seb-1 0.0228 0.5376 0.6044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0437 0.0578
Brugia malayi Latrophilin receptor protein 2 0.0072 0.1382 0.1554
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0925 0.1223
Schistosoma mansoni hypothetical protein 0.0146 0.3274 0.4329
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0228 0.5376 0.6044
Brugia malayi latrophilin 2 splice variant baaae 0.0156 0.3527 0.3966
Echinococcus multilocularis GPCR, family 2 0.0072 0.1382 0.1382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0284 0.0375
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0925 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0925 0.0925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0847
Schistosoma mansoni hypothetical protein 0.0072 0.1382 0.1827
Brugia malayi TAR-binding protein 0.0076 0.1495 0.1681
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.3274 0.3274
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.3274 0.3274
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0072 0.1382 0.1382
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1495 0.1681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0832 0.11
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0925 0.1223
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1495 0.1977
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0365 0.0482
Schistosoma mansoni hypothetical protein 0.0072 0.1382 0.1827
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0832 0.11
Loa Loa (eye worm) hypothetical protein 0.0156 0.3527 0.3966
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0642 0.6934
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0832 0.0832
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0072 0.1382 0.1382
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0832 0.0936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0467 0.0617
Schistosoma mansoni hypothetical protein 0.0156 0.3527 0.4663
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0642 0.6934
Trichomonas vaginalis glutaminase, putative 0.0313 0.7564 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1495 0.1977
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0642 0.6934
Schistosoma mansoni hypothetical protein 0.0072 0.1382 0.1827
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0752
Echinococcus granulosus GPCR family 2 0.0072 0.1382 0.1382
Echinococcus multilocularis thyroid hormone receptor alpha 0.0158 0.3575 0.3575
Brugia malayi glutaminase DH11.1 0.0313 0.7564 0.8504
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0752
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.3081 0.3464
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0072 0.1382 0.1554
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1065 0.1408
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0191 0.207
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0925 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0722 0.0954
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1495 0.1681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0357 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0284 0.0375
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0925 1
Brugia malayi hypothetical protein 0.0365 0.8895 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1065 0.1198
Mycobacterium ulcerans glutaminase 0.0313 0.7564 0.5
Loa Loa (eye worm) hypothetical protein 0.0365 0.8895 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0925 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0357 0.0472
Schistosoma mansoni thyroid hormone receptor 0.0158 0.3575 0.4726
Echinococcus granulosus tar DNA binding protein 0.0076 0.1495 0.1495
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0111 0.1204
Loa Loa (eye worm) glutaminase 2 0.0313 0.7564 0.8504
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0752
Schistosoma mansoni thyroid hormone receptor 0.0158 0.3575 0.4726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0377
Schistosoma mansoni hypothetical protein 0.0072 0.1382 0.1827
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1495 0.1495
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0925 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0752
Loa Loa (eye worm) latrophilin receptor protein 2 0.0072 0.1382 0.1554
Loa Loa (eye worm) glutaminase 0.0313 0.7564 0.8504
Brugia malayi hypothetical protein 0.0043 0.0648 0.0728
Brugia malayi RNA binding protein 0.0076 0.1495 0.1681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0847
Brugia malayi MH2 domain containing protein 0.0138 0.3081 0.3464
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0648 0.0648
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1495 0.1977
Onchocerca volvulus 0.0365 0.8895 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0365 0.0482
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0072 0.1382 0.1382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0832 0.11
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0925 0.0925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0925 0.1223
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0648 0.0648
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1495 0.1977

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0037 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 0.4645 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.0323 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2995 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8356 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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