Detailed information for compound 1248983

Basic information

Technical information
  • TDR Targets ID: 1248983
  • Name: N-quinolin-8-ylcyclopentanecarboxamide
  • MW: 240.3 | Formula: C15H16N2O
  • H donors: 1 H acceptors: 2 LogP: 2.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCC1)Nc1cccc2c1nccc2
  • InChi: 1S/C15H16N2O/c18-15(12-5-1-2-6-12)17-13-9-3-7-11-8-4-10-16-14(11)13/h3-4,7-10,12H,1-2,5-6H2,(H,17,18)
  • InChiKey: HSNALWQCACCJOH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(8-quinolyl)cyclopentanecarboxamide
  • MLS000705862
  • N-(8-quinolinyl)cyclopentanecarboxamide
  • SMR000229054
  • ZINC00363622
  • AN-652/41792982

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.0174 0.9413 0.9387
Schistosoma mansoni lamin 0.0029 0.08 0.0391
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0656 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3618 0.3335
Leishmania major hypothetical protein, conserved 0.0027 0.0656 1
Echinococcus granulosus lamin 0.0029 0.08 0.0391
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0656 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0656 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 1 1
Echinococcus multilocularis geminin 0.0174 0.9413 0.9387
Loa Loa (eye worm) TAR-binding protein 0.0076 0.3618 0.3618
Schistosoma mansoni hypothetical protein 0.0174 0.9413 0.9387
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.3618 0.3618
Echinococcus multilocularis musashi 0.0029 0.08 0.0391
Brugia malayi TAR-binding protein 0.0076 0.3618 0.3618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.08 0.08
Schistosoma mansoni intermediate filament proteins 0.0029 0.08 0.0391
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0426 0.5
Brugia malayi hypothetical protein 0.0017 0.0097 0.0097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0656 0.0656
Schistosoma mansoni lamin 0.0029 0.08 0.0391
Onchocerca volvulus 0.0029 0.08 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 1 1
Brugia malayi intermediate filament protein 0.0029 0.08 0.08
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0426 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3618 0.3335
Echinococcus multilocularis tar DNA binding protein 0.0076 0.3618 0.3335
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0426 0.0426
Loa Loa (eye worm) RNA binding protein 0.0076 0.3618 0.3618
Echinococcus granulosus tar DNA binding protein 0.0076 0.3618 0.3335
Brugia malayi hypothetical protein 0.0027 0.0656 0.0656
Loa Loa (eye worm) intermediate filament protein 0.0029 0.08 0.08
Brugia malayi RNA binding protein 0.0076 0.3618 0.3618
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0656 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0426 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3618 0.3335
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3618 0.3335
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0656 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0426 0.5
Schistosoma mansoni hypothetical protein 0.0174 0.9413 0.9387
Loa Loa (eye worm) hypothetical protein 0.0029 0.08 0.08
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0426 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0426 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0426 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.3618 0.3618
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.08 0.08
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0426 0.5
Echinococcus granulosus intermediate filament protein 0.0029 0.08 0.0391
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0656 1
Echinococcus multilocularis lamin dm0 0.0029 0.08 0.0391
Onchocerca volvulus 0.0029 0.08 0.5
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0426 0.0426
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0656 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3618 0.3335
Echinococcus multilocularis lamin 0.0029 0.08 0.0391
Loa Loa (eye worm) hypothetical protein 0.0028 0.0768 0.0768
Echinococcus granulosus lamin dm0 0.0029 0.08 0.0391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0025 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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