TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 287.319 | Formula: C17H13N5
H donors: 1 H acceptors: 3 LogP: 3.16 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cc1)Nc1nc(cn2c1ncc2)c1cccnc1
InChi: 1S/C17H13N5/c1-2-6-14(7-3-1)20-16-17-19-9-10-22(17)12-15(21-16)13-5-4-8-18-11-13/h1-12H,(H,20,21)
InChiKey: CNGRDQUSESKDGD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0349	0.0552	0.3683
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0805	0.1615	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0349	0.0552	0.0652
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.2968	0.6662	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0349	0.0552	0.0765
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trichomonas vaginalis	conserved hypothetical protein	0.0236	0.0289	0.0829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.0243	0.0698
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.4398	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0349	0.0552	0.1583
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0236	0.0289	0.1478
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.026	0.0343	0.0986
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0217	0.0243	0.0698
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.1362	0.2917	0.8352
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0349	0.0552	0.3683
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0243	0.041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0472	0.0838	0.2405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.026	0.0343	0.5
Echinococcus multilocularis	Zinc finger, PHD finger	0.026	0.0343	0.0299
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0217	0.0243	0.0198
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.1121	0.2353	0.6754
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.026	0.0343	0.0299
Loa Loa (eye worm)	phosphatidylinositol 3	0.0349	0.0552	0.0931
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0349	0.0552	0.1583
Loa Loa (eye worm)	phosphatidylinositol 3	0.0472	0.0838	0.1414
Echinococcus multilocularis	geminin	0.0189	0.0179	0.0134
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.106	0.2211	0.63
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.026	0.0343	0.0867
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0217	0.0243	0.0574
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0349	0.0552	0.1472
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.1501	0.324	0.925
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.026	0.0343	0.045
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0576	0.1081	0.3103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.0243	0.0698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.026	0.0343	0.1199
Loa Loa (eye worm)	phosphatidylinositol 3	0.0349	0.0552	0.0931
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0217	0.0243	0.0574
Loa Loa (eye worm)	phosphatidylinositol 3	0.2652	0.5925	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0217	0.0243	0.0298
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.026	0.0343	0.0986
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0576	0.1081	0.3011
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0349	0.0552	0.0652
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0349	0.0552	0.0652
Loa Loa (eye worm)	hypothetical protein	0.106	0.2211	0.3732
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0046	0.0077
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0217	0.0243	0.0698
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0349	0.0552	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0349	0.0552	0.3683
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Schistosoma mansoni	hypothetical protein	0.0189	0.0179	0.0201
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1289	0.2746	0.7724
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.0243	0.0698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Echinococcus granulosus	serine protein kinase ATM	0.0217	0.0243	0.0198
Leishmania major	hypothetical protein, conserved	0.1626	0.3532	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.026	0.0343	0.0986
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.026	0.0343	0.045
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.106	0.2211	0.2176
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.0243	0.0698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0349	0.0552	0.0652
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1605	0.3483	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0236	0.0289	0.0829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.0243	0.0698
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.2968	0.6662	0.6647
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.042	0.0717	0.1559
Schistosoma mansoni	hypothetical protein	0.0189	0.0179	0.0201
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0349	0.0552	0.0508
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.026	0.0343	0.031
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Schistosoma mansoni	hypothetical protein	0.0322	0.0489	0.067
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.026	0.0343	0.058
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0349	0.0552	0.0508
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0576	0.1081	0.3103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.0243	0.0698
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.1605	0.3483	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Echinococcus multilocularis	snurportin 1	0.0322	0.0489	0.0445
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Echinococcus granulosus	geminin	0.0189	0.0179	0.0134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trypanosoma cruzi	target of rapamycin kinase 3	0.0349	0.0552	0.1583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.026	0.0343	0.0299
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.2968	0.6662	0.6647
Echinococcus multilocularis	serine protein kinase ATM	0.0217	0.0243	0.0198
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0349	0.0552	0.1472
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0349	0.0552	0.3683
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0349	0.0552	0.0952
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.106	0.2211	0.2176
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Echinococcus granulosus	snurportin 1	0.0322	0.0489	0.0445
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1605	0.3483	1
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.026	0.0343	0.031
Loa Loa (eye worm)	hypothetical protein	0.0236	0.0289	0.0487
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.026	0.0343	0.5
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0349	0.0552	0.3683
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0217	0.0243	0.0298
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.026	0.0343	0.0986
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0576	0.1081	0.1564
Trichomonas vaginalis	conserved hypothetical protein	0.0132	0.0046	0.0131
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0576	0.1081	0.2586
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0576	0.1081	0.3103
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0576	0.1081	1
Entamoeba histolytica	hypothetical protein	0.1289	0.2746	0.7724
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0349	0.0552	0.0765
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0349	0.0552	0.1583
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.026	0.0343	0.0299
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.1605	0.3483	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0349	0.0552	0.1583
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.1605	0.3483	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.1605	0.3483	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.026	0.0343	0.0986
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0236	0.0289	0.0544
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.026	0.0343	0.3256
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.026	0.0343	0.3256
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0349	0.0552	0.0652
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0322	0.0489	0.0825
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0349	0.0552	0.0508
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.1121	0.2353	0.6754
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.1605	0.3483	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0576	0.1081	0.2586
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0349	0.0552	0.1583
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0576	0.1081	0.3103
Loa Loa (eye worm)	hypothetical protein	0.0545	0.1009	0.1703
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.0243	0.0698
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0349	0.0552	0.0952
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0744	0.1474	0.3799
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0349	0.0552	0.0508
Trypanosoma cruzi	hypothetical protein, conserved	0.1522	0.3289	0.9444
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0217	0.0243	0.0698
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0217	0.0243	0.0198

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.7 uM	Inhibition of human aurora A	ChEMBL.	20833547

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1257210

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1265295