Detailed information for compound 1271984

Basic information

Technical information
  • TDR Targets ID: 1271984
  • Name: 4-fluoro-N-[[4-[(5-methyl-1,2-oxazol-3-yl)sul famoyl]phenyl]carbamothioyl]benzamide
  • MW: 434.465 | Formula: C18H15FN4O4S2
  • H donors: 3 H acceptors: 4 LogP: 3.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(NC(=O)c1ccc(cc1)F)Nc1ccc(cc1)S(=O)(=O)Nc1noc(c1)C
  • InChi: 1S/C18H15FN4O4S2/c1-11-10-16(22-27-11)23-29(25,26)15-8-6-14(7-9-15)20-18(28)21-17(24)12-2-4-13(19)5-3-12/h2-10H,1H3,(H,22,23)(H2,20,21,24,28)
  • InChiKey: QJMJYCFYKDUAQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-fluoro-N-[[4-[(5-methylisoxazol-3-yl)sulfamoyl]phenyl]carbamothioyl]benzamide
  • 4-fluoro-N-[[[4-[(5-methyl-3-isoxazolyl)sulfamoyl]phenyl]amino]-thioxomethyl]benzamide
  • 4-fluoro-N-[[4-[(5-methylisoxazol-3-yl)sulfamoyl]phenyl]thiocarbamoyl]benzamide
  • 4-[3-(4-Fluoro-benzoyl)-thioureido]-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide
  • MLS000553630
  • SMR000171449
  • BAS 00435341

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Onchocerca volvulus 0.007 0.0113 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Schistosoma mansoni hypothetical protein 0.0123 0.046 0.046
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.1583 1 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0118 0.0428 0.5047
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Loa Loa (eye worm) hypothetical protein 0.1465 0.9227 0.9227
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0118 0.0428 0.5047
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Mycobacterium leprae Probable lipase LipE 0.007 0.0113 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Leishmania major hypothetical protein, conserved 0.0118 0.0428 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Brugia malayi MH2 domain containing protein 0.0232 0.1173 0.1173
Leishmania major hypothetical protein, conserved 0.0118 0.0428 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0165 0.0731 0.0731
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.1583 1 1
Schistosoma mansoni hypothetical protein 0.0282 0.1495 0.1495
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.1465 0.9227 0.9227
Echinococcus granulosus aryl hydrocarbon receptor 0.0068 0.0101 0.1192
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0068 0.0101 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Brugia malayi hypothetical protein 0.0068 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.007 0.0113 0.0113
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0118 0.0428 1
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0428 1
Onchocerca volvulus 0.007 0.0113 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0068 0.0101 0.1192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0113 0.0113
Plasmodium vivax phosphodiesterase gamma, putative 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0068 0.0101 0.5
Giardia lamblia hypothetical protein 0.0118 0.0428 0.5
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.046 0.5429
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0113 0.0364
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0113 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0113 0.0364
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0113 0.0364
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0118 0.0428 0.0428
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.1173 0.1173
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.0594 0.7009
Loa Loa (eye worm) hypothetical protein 0.0101 0.0317 0.0317
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0594 0.0594
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0118 0.0428 0.5047
Loa Loa (eye worm) hypothetical protein 0.0118 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.1583 1 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0428 0.0428
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0118 0.0428 0.5
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0466 0.549
Schistosoma mansoni lipoxygenase 0.0124 0.0466 0.0466
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Brugia malayi PAS domain containing protein 0.0068 0.0101 0.0101
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0466 0.549
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0118 0.0428 0.5047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.007 0.0113 0.0113
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0118 0.0428 0.5047
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0428 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0428 0.0428
Schistosoma mansoni single-minded 0.0068 0.0101 0.0101
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0428 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0118 0.0428 0.5047
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0118 0.0428 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0118 0.0428 0.5
Loa Loa (eye worm) hypothetical protein 0.1465 0.9227 0.9227
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Leishmania major hypothetical protein, conserved 0.007 0.0113 0.0364
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0118 0.0428 0.0428
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.0428 1
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0428 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0118 0.0428 0.5047
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0428 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0118 0.0428 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0113 0.0113
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0118 0.0428 0.5047
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Mycobacterium leprae conserved hypothetical protein 0.007 0.0113 1
Brugia malayi beta-lactamase family protein 0.007 0.0113 0.0113
Loa Loa (eye worm) PDE1B protein 0.0118 0.0428 0.0428
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0118 0.0428 0.0428
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0118 0.0428 0.0428
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0113 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0118 0.0428 0.5047
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0428 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0118 0.0428 0.0428
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0068 0.0101 0.0101
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0118 0.0428 0.0428
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Brugia malayi beta-lactamase family protein 0.007 0.0113 0.0113
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Mycobacterium ulcerans beta-lactamase 0.007 0.0113 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Echinococcus granulosus geminin 0.0165 0.0731 0.8615
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0118 0.0428 0.0428
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0118 0.0428 0.0428
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0113 0.1332
Loa Loa (eye worm) hypothetical protein 0.007 0.0113 0.0113
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Onchocerca volvulus 0.007 0.0113 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0428 0.5047
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0118 0.0428 0.0428
Mycobacterium ulcerans hypothetical protein 0.007 0.0113 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0118 0.0428 0.5047
Loa Loa (eye worm) hypothetical protein 0.0068 0.0101 0.0101
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0118 0.0428 0.0428
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0118 0.0428 0.5047
Trichomonas vaginalis esterase, putative 0.007 0.0113 0.0364
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0118 0.0428 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0118 0.0428 0.5047
Loa Loa (eye worm) hypothetical protein 0.0069 0.0107 0.0107
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0118 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.007 0.0113 0.0113
Echinococcus multilocularis geminin 0.0165 0.0731 0.8615
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0447 0.2579 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0068 0.0101 0.1192
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0118 0.0428 0.0428
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0113 0.5
Giardia lamblia Hypothetical protein 0.0118 0.0428 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0118 0.0428 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0428 1
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0113 0.0364
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0118 0.0428 0.5047
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0118 0.0428 0.0428
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0118 0.0428 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0118 0.0428 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0428 1
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0428 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0118 0.0428 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.0101 0.0101
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0118 0.0428 0.5047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0317 0.0317
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0118 0.0428 0.0428
Loa Loa (eye worm) beta-lactamase 0.007 0.0113 0.0113
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0113 0.0113
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0428 1
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.1173 0.1173
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0428 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0428 1
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0113 0.0364
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0113 0.1332
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.0848 1
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0428 1
Schistosoma mansoni lipoxygenase 0.0087 0.0222 0.0222
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0428 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Brugia malayi beta-lactamase 0.007 0.0113 0.0113
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0113 0.0113
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.0848 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0428 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0068 0.0101 0.1192
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.046 0.5429
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Schistosoma mansoni hypothetical protein 0.0165 0.0731 0.0731
Leishmania major cAMP-specific phosphodiesterase, putative 0.0118 0.0428 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0118 0.0428 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0428 0.5047
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0118 0.0428 1
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0113 0.0364
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0107 0.0107
Mycobacterium ulcerans lipase LipD 0.007 0.0113 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0428 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0118 0.0428 0.0428
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0428 1
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0113 0.0364
Schistosoma mansoni hypothetical protein 0.0069 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.007 0.0113 0.0113

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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