Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Lethal(3)malignant brain tumor-like 4 protein, putative | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Schistosoma japonicum | Lethal(3)malignant brain tumor-like 3 protein, putative | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.2745 | 1 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0066 | 0.003 | 0.003 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.2745 | 1 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0227 | 0.063 | 0.063 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0058 | 0 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2745 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.1089 | 0.1089 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0066 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0058 | 0 | 0.5 | |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0066 | 0.003 | 0.003 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0066 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.003 | 0.003 |
Loa Loa (eye worm) | MBCTL1 | 0.0066 | 0.003 | 0.003 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.2745 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.2745 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2745 | 1 | 1 |
Leishmania major | 0.2745 | 1 | 0.5 | |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.2745 | 1 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0227 | 0.063 | 0.063 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0066 | 0.003 | 0.003 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0066 | 0.003 | 0.003 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.2745 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7943 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.