Detailed information for compound 1274892

Basic information

Technical information
  • TDR Targets ID: 1274892
  • Name: [2-(2,4-dichlorophenyl)-2-oxoethyl] 2-(furan- 2-carbonylamino)acetate
  • MW: 356.158 | Formula: C15H11Cl2NO5
  • H donors: 1 H acceptors: 3 LogP: 3.19 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNC(=O)c1ccco1)OCC(=O)c1ccc(cc1Cl)Cl
  • InChi: 1S/C15H11Cl2NO5/c16-9-3-4-10(11(17)6-9)12(19)8-23-14(20)7-18-15(21)13-2-1-5-22-13/h1-6H,7-8H2,(H,18,21)
  • InChiKey: CUACCXSIRZKJER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(2,4-dichlorophenyl)-2-oxo-ethyl] 2-(furan-2-carbonylamino)acetate
  • 2-[(2-furyl-oxomethyl)amino]acetic acid [2-(2,4-dichlorophenyl)-2-oxoethyl] ester
  • 2-(furan-2-carbonylamino)acetic acid [2-(2,4-dichlorophenyl)-2-keto-ethyl] ester
  • [2-(2,4-dichlorophenyl)-2-oxo-ethyl] 2-(furan-2-ylcarbonylamino)ethanoate
  • BAS 06807202
  • ZINC02251586
  • TULIP014872
  • MLS000707928
  • SMR000288995

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.056 0.6283 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0273 0.1311
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0021 0.0192 0.6519
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0273 0.0228
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0273 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0524 0.0835
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0021 0.0192 0.0919
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0273 0.1311
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.0192 0.0919
Onchocerca volvulus 0.0028 0.0273 0.6679
Trypanosoma brucei cysteine peptidase C (CPC) 0.0187 0.2076 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0192 0.0919
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0021 0.0192 0.6519
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0244
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0068 0.0035
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0273 0.0374
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0021 0.0192 0.6519
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0021 0.0192 0.0244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.056 0.6283 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0021 0.0192 0.6519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0192 0.0919
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0021 0.0192 0.0919
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0244
Onchocerca volvulus 0.0028 0.0273 0.6679
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0021 0.0192 0.6519
Brugia malayi Cathepsin L-like precursor 0.0021 0.0192 0.0244
Loa Loa (eye worm) hypothetical protein 0.056 0.6283 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0244
Echinococcus granulosus cathepsin l1 0.0021 0.0192 0.0233
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.056 0.6283 1
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0273 0.6679
Plasmodium vivax vivapain-2 0.0028 0.0273 1
Echinococcus granulosus cysteine protease 0.0028 0.0273 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0192 0.0919
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0273 0.0435
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0273 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0712 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0192 0.0919
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0273 0.0374
Plasmodium vivax serine-repeat antigen (SERA) 0.0021 0.0192 0.6519
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0273 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0273 0.1311
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0039 0.018
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0273 0.0364
Brugia malayi cathepsin L-like cysteine proteinase 0.0021 0.0192 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.0192 0.0244
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Echinococcus multilocularis cathepsin b 0.056 0.6283 0.6265
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0039 0.018
Echinococcus granulosus cpg binding protein 0.0033 0.0334 0.0461
Echinococcus multilocularis cpg binding protein 0.0033 0.0334 0.0289
Entamoeba histolytica hypothetical protein 0.0021 0.0192 0.7021
Loa Loa (eye worm) cathepsin B 0.0187 0.2076 0.3261
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0021 0.0192 0.0919
Toxoplasma gondii cathepsin CPL 0.0028 0.0273 0.0432
Echinococcus granulosus cathepsin L 0.0028 0.0273 0.0364
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.0192 0.0244
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0021 0.0192 0.7021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Entamoeba histolytica cysteine protease, putative 0.0021 0.0192 0.7021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0009 0.0014
Brugia malayi Cathepsin L-like precursor 0.0028 0.0273 0.0374
Brugia malayi Cathepsin L-like precursor 0.0021 0.0192 0.0244
Onchocerca volvulus 0.0028 0.0273 0.6679
Brugia malayi cathepsin L precursor 0.0021 0.0192 0.0244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.0192 0.0305
Plasmodium falciparum serine repeat antigen 3 0.0021 0.0192 0.7021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0187 0.2076 0.3304
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0021 0.0192 0.6519
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0273 0.1311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0192 0.0919
Loa Loa (eye worm) cysteine protease 0.0028 0.0273 0.0374
Giardia lamblia Cathepsin B precursor 0.0187 0.2076 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0244
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0068 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0273 0.0228
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0021 0.0192 0.6519
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0524 0.0767
Entamoeba histolytica cysteine protease, putative 0.0021 0.0192 0.7021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0273 0.1311
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0187 0.2076 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0273 0.0435
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0273 0.0435
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0021 0.0192 0.7021
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0273 0.0374
Entamoeba histolytica cysteine protease, putative 0.0021 0.0192 0.7021
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0039 0.018
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0021 0.0192 0.0919
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0273 0.0374
Plasmodium falciparum cysteine proteinase falcipain 3 0.0028 0.0273 1
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0273 0.0374
Loa Loa (eye worm) histone methyltransferase 0.001 0.0068 0.0046
Echinococcus multilocularis cathepsin b 0.056 0.6283 0.6265
Entamoeba histolytica cysteine protease, putative 0.0021 0.0192 0.7021
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.056 0.6283 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0021 0.0192 0.0919
Plasmodium falciparum serine repeat antigen 1 0.0021 0.0192 0.7021
Plasmodium vivax unspecified product 0.0021 0.0192 0.6519
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0021 0.0192 0.0305
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0244
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0273 0.0374
Brugia malayi Cathepsin L-like precursor 0.0028 0.0273 0.0374
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.0192 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0039 0.018
Echinococcus multilocularis cathepsin L 0.0028 0.0273 0.0228
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0273 0.1311
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0273 1
Onchocerca volvulus 0.0028 0.0273 0.6679
Toxoplasma gondii cathepsin B 0.0187 0.2076 1
Schistosoma mansoni cpg binding protein 0.0033 0.0334 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0192 0.0919
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0039 0.018
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0021 0.0192 0.7021
Entamoeba histolytica cysteine protease, putative 0.0021 0.0192 0.7021
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0021 0.0192 0.7021
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0273 0.0374
Onchocerca volvulus 0.0031 0.0314 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.0314 0.0439
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0021 0.0192 0.0244
Schistosoma mansoni cathepsin s 0.0007 0.0039 0.0063
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0273 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0273 0.1311
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0192 0.7021
Trichomonas vaginalis helicase, putative 0.0007 0.0039 0.018
Onchocerca volvulus 0.0028 0.0273 0.6679
Echinococcus multilocularis cysteine protease 0.0028 0.0273 0.0228
Onchocerca volvulus Cathepsin F homolog 0.0028 0.0273 0.6679
Trypanosoma cruzi cruzipain precursor, putative 0.0028 0.0273 0.0374
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0273 0.0435
Schistosoma mansoni cathepsin F (C01 family) 0.0021 0.0192 0.0305
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0021 0.0192 0.6519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Brugia malayi Cathepsin L-like cysteine proteinase 0.0021 0.0192 0.0244
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0192 0.0919
Schistosoma mansoni cathepsin C 0.0021 0.0192 0.0305
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0039 0.018
Plasmodium falciparum serine repeat antigen 9 0.0021 0.0192 0.7021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0524 0.0777
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0039 0.018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0021 0.0192 0.0244
Plasmodium falciparum serine repeat antigen 8 0.0021 0.0192 0.7021
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0039 0.018
Plasmodium falciparum serine repeat antigen 7 0.0021 0.0192 0.7021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0046 0.0074
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0039 0.018
Plasmodium falciparum serine repeat antigen 6 0.0021 0.0192 0.7021
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0021 0.0192 0.0305
Onchocerca volvulus 0.0028 0.0273 0.6679
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0039 0.018
Brugia malayi Cathepsin L-like precursor 0.0028 0.0273 0.0374
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0273 0.6679
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0273 0.1311
Trypanosoma cruzi major cysteine proteinase, putative 0.0021 0.0192 0.0244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0273 0.1311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.0192 0.0919
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.056 0.6283 1
Schistosoma mansoni cathepsin B (C01 family) 0.0021 0.0192 0.0305
Schistosoma mansoni cpg binding protein 0.0033 0.0334 0.0532
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0021 0.0192 0.6519
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0273 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0273 0.1311
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0273 0.0374
Echinococcus granulosus cathepsin l1 0.0028 0.0273 0.0364
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0273 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0039 0.018
Echinococcus granulosus cathepsin L 0.0021 0.0192 0.0233
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0632 0.2336
Onchocerca volvulus 0.0028 0.0273 0.6679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0273 0.0374
Echinococcus granulosus cathepsin b 0.056 0.6283 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0524 0.0835
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0021 0.0192 0.0919
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0039 0.018
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0273 0.0374
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0273 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Entamoeba histolytica cysteine protease, putative 0.0021 0.0192 0.7021
Brugia malayi Cathepsin L-like precursor 0.0028 0.0273 0.0374
Brugia malayi Cathepsin L-like precursor 0.0028 0.0273 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0187 0.2076 1
Plasmodium falciparum serine repeat antigen 2 0.0021 0.0192 0.7021
Plasmodium falciparum serine repeat antigen 5 0.0021 0.0192 0.7021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0039 0.018
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0021 0.0192 0.7021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0192 0.0919
Plasmodium vivax vivapain-3 0.0028 0.0273 1
Brugia malayi Papain family cysteine protease containing protein 0.0021 0.0192 0.0244
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0273 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0039 0.018
Schistosoma mansoni cpg binding protein 0.0031 0.0314 0.0499
Brugia malayi cathepsin Z-like cysteine proteinase 0.0021 0.0192 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0021 0.0192 0.0919
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0192 0.0919
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0192 0.0919
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0273 0.1311
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0273 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0021 0.0192 0.0244
Trypanosoma cruzi major cysteine proteinase, putative 0.0021 0.0192 0.0244
Echinococcus granulosus cathepsin l cysteine peptidase 0.0028 0.0273 0.0364
Plasmodium falciparum serine repeat antigen 4 0.0021 0.0192 0.7021
Loa Loa (eye worm) ctsf protein 0.0028 0.0273 0.0374
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0039 0.018
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0273 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0187 0.2076 0.3261
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0314 0.0439
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0273 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0524 0.0835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0273 0.1311
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0039 0.018
Echinococcus multilocularis cathepsin L 0.0021 0.0192 0.0146
Loa Loa (eye worm) fibroinase 0.0028 0.0273 0.0374
Echinococcus granulosus cathepsin b 0.056 0.6283 1
Brugia malayi cathepsin B-like cysteine proteinase 0.056 0.6283 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0067 0.0044
Brugia malayi Cathepsin L-like precursor 0.0028 0.0273 0.0374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0524 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0021 0.0192 0.0919
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0021 0.0192 0.0305
Plasmodium vivax unspecified product 0.0028 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0244
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0273 0.0374
Plasmodium vivax serine-repeat antigen (SERA) 0.0021 0.0192 0.6519
Giardia lamblia Cathepsin B precursor 0.0187 0.2076 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0021 0.0192 0.0919
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0021 0.0192 0.6519
Echinococcus granulosus cathepsin L cysteine proteinase 0.0028 0.0273 0.0364
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0524 0.048
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0273 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0039 0.018
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0028 0.0273 0.0374
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0021 0.0192 0.0244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0244
Schistosoma mansoni cathepsin S (C01 family) 0.0021 0.0192 0.0305
Brugia malayi cathepsin F-like cysteine proteinase 0.0021 0.0192 0.0244
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0021 0.0192 0.0305
Plasmodium vivax vivapain-2 0.0028 0.0273 1
Brugia malayi fibroinase precursor 0.0021 0.0192 0.0244
Giardia lamblia Cathepsin B precursor 0.0187 0.2076 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0273 1
Brugia malayi cathepsin L-like precursor 0.0021 0.0192 0.0244
Echinococcus multilocularis cysteine protease 0.0028 0.0273 0.0228
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.0192 0.0305
Plasmodium vivax vivapain-1 0.0028 0.0273 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0021 0.0192 0.0244
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0524 0.048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.0192 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0524 0.0767
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0273 0.0374
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0021 0.0192 0.0305

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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