Detailed information for compound 1275303

Basic information

Technical information
  • TDR Targets ID: 1275303
  • Name: (4-methylpiperazin-1-yl)-[5-phenyl-7-(trifluo romethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methan one
  • MW: 389.374 | Formula: C19H18F3N5O
  • H donors: 0 H acceptors: 3 LogP: 2.51 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C(=O)c1cc2n(n1)c(cc(n2)c1ccccc1)C(F)(F)F
  • InChi: 1S/C19H18F3N5O/c1-25-7-9-26(10-8-25)18(28)15-12-17-23-14(13-5-3-2-4-6-13)11-16(19(20,21)22)27(17)24-15/h2-6,11-12H,7-10H2,1H3
  • InChiKey: DQMZVMDRFHMFIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4-methyl-1-piperazinyl)-[5-phenyl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]methanone
  • 2-[(4-methyl-1-piperazinyl)carbonyl]-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
  • ST5002077
  • SMR000070063
  • MLS000062067
  • BAS 00398181
  • BIM-0027913.P001
  • CBMicro_028139

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0026 0.0571
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0034 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0587 0.2222
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0324 0.1226
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0463 0.1778
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0463 0.1778
Brugia malayi GMP reductase 0.0101 0.1121 0.4245
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0463 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0701 0.2691
Brugia malayi jmjC domain containing protein 0.0019 0.0165 0.0627
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0165 0.0635
Toxoplasma gondii IMP dehydrogenas 0.0229 0.2605 1
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0165 0.0635
Echinococcus multilocularis muscleblind protein 1 0.018 0.2038 0.2038
Loa Loa (eye worm) hypothetical protein 0.018 0.2038 0.7722
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0167 0.0642
Trichomonas vaginalis helicase, putative 0.0007 0.0026 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0026 0.0571
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0229 0.2605 1
Brugia malayi jmjC domain containing protein 0.0019 0.0165 0.0627
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0229 0.2605 1
Schistosoma mansoni ap endonuclease 0.0019 0.0167 0.0642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0587 0.1128
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0128 0.143 0.549
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0167 0.0642
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.079 0.1519
Schistosoma mansoni hypothetical protein 0.0033 0.0329 0.1262
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0229 0.2605 0.2605
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0463 0.1778
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0186 0.0357
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0229 0.2605 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0324 0.1226
Loa Loa (eye worm) inositol-1 0.0045 0.0463 0.1755
Echinococcus multilocularis lamin dm0 0.0033 0.0324 0.0324
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0165 0.0318
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0026 0.0571
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0506 0.1917
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0165 0.0635
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0324 0.1226
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0165 0.0318
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0229 0.2605 0.5009
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0148 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0026 0.0571
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0587 0.0587
Echinococcus multilocularis lamin 0.0033 0.0324 0.0324
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0167 0.0642
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0463 0.1778
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.0571
Trypanosoma brucei GMP reductase 0.0229 0.2605 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0123 0.0123
Echinococcus granulosus GPCR family 2 0.0015 0.0123 0.0237
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0165 0.0627
Loa Loa (eye worm) hypothetical protein 0.0015 0.0123 0.0466
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0463 1
Trypanosoma cruzi GMP reductase 0.0229 0.2605 1
Schistosoma mansoni cpg binding protein 0.0032 0.0322 0.1237
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0167 0.5
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0165 0.0165
Brugia malayi jmjC domain containing protein 0.0019 0.0165 0.0627
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0167 0.0642
Onchocerca volvulus Putative GMP reductase 0.0101 0.1121 1
Brugia malayi hypothetical protein 0.0232 0.264 1
Schistosoma mansoni lamin 0.0033 0.0324 0.1242
Onchocerca volvulus 0.0047 0.0495 0.442
Brugia malayi jmjC domain containing protein 0.0071 0.077 0.2916
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0056 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0026 0.0571
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0409 0.157
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0229 0.2605 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0167 0.0322
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0123 0.0123
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.079 0.2993
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0165 0.0635
Schistosoma mansoni hypothetical protein 0.0015 0.0123 0.0472
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0463 0.0891
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0506 0.1917
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0101 0.1121 0.4245
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.0571
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0229 0.2605 1
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0165 0.0318
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0123 0.0466
Loa Loa (eye worm) GMP reductase 0.0101 0.1121 0.4245
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0055 0.0207
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0506 0.1917
Brugia malayi intermediate filament protein 0.0033 0.0324 0.1226
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0165 0.0165
Schistosoma mansoni intermediate filament proteins 0.0033 0.0324 0.1242
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0587 0.1128
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0005 0 0.5
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0148 0.0561
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0229 0.2605 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0123 0.0466
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0167 0.0634
Echinococcus granulosus lamin dm0 0.0033 0.0324 0.0622
Leishmania major hypothetical protein, conserved 0.0019 0.0165 0.0635
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.077 0.077
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0167 1
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.52 0.52
Echinococcus granulosus intermediate filament protein 0.0033 0.0324 0.0622
Echinococcus granulosus phd:f box containing protein 0.0019 0.0165 0.0318
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.264 0.264
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0232 0.264 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0165 0.0627
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.077 0.148
Toxoplasma gondii exonuclease III APE 0.0019 0.0167 0.0642
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0587 0.2222
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0165 0.0635
Leishmania major inosine-5-monophosphate dehydrogenase 0.0229 0.2605 1
Echinococcus multilocularis geminin 0.0181 0.2047 0.2047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0317 0.12
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0026 0.0571
Loa Loa (eye worm) hypothetical protein 0.0016 0.0128 0.0485
Brugia malayi CXXC zinc finger family protein 0.0031 0.0302 0.1144
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0165 0.0627
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0056 0.0108
Brugia malayi jmjC domain containing protein 0.0019 0.0165 0.0627
Schistosoma mansoni jumonji domain containing protein 0.0071 0.077 0.2955
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0128 0.143 0.549
Loa Loa (eye worm) hypothetical protein 0.0033 0.0329 0.1245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0587 0.2252
Echinococcus granulosus geminin 0.0181 0.2047 0.3936
Echinococcus multilocularis musashi 0.0033 0.0324 0.0324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0587 0.2252
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.079 0.3033
Schistosoma mansoni hypothetical protein 0.0181 0.2047 0.7858
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0463 0.0463
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0229 0.2605 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0463 1
Schistosoma mansoni hypothetical protein 0.0015 0.0123 0.0472
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0165 0.0165
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0167 0.3612
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0123 0.0466
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0167 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0026 0.0571
Schistosoma mansoni cpg binding protein 0.0032 0.0322 0.1237
Brugia malayi jmjC domain containing protein 0.0073 0.079 0.2993
Schistosoma mansoni hypothetical protein 0.0015 0.0123 0.0472
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0229 0.2605 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.0571
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0026 0.0571
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0463 0.1778
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0056 0.0056
Echinococcus multilocularis muscleblind protein 0.018 0.2038 0.2038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.079 0.3033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0123 0.0237
Loa Loa (eye worm) hypothetical protein 0.018 0.2038 0.7722
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0167 0.0642
Loa Loa (eye worm) hypothetical protein 0.0048 0.0506 0.1917
Onchocerca volvulus 0.0033 0.0324 0.2888
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0101 0.1121 0.4302
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0409 0.157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0587 0.2252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.0571
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0034 0.0131
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0167 0.0634
Onchocerca volvulus 0.0033 0.0324 0.2888
Schistosoma mansoni hypothetical protein 0.0047 0.0495 0.1901
Echinococcus granulosus cpg binding protein 0.0032 0.0322 0.062
Onchocerca volvulus 0.0031 0.0302 0.2694
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0026 0.0571
Schistosoma mansoni hypothetical protein 0.0181 0.2047 0.7858
Echinococcus granulosus lamin 0.0033 0.0324 0.0622
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0495 0.1876
Schistosoma mansoni cpg binding protein 0.0031 0.0302 0.1159
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0587 0.0587
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0229 0.2605 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.0571
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0034 0.0034
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0128 0.0246
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0229 0.2605 1
Brugia malayi Muscleblind-like protein 0.018 0.2038 0.7722
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0034 0.0034
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0167 0.0008
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0165 0.0635
Loa Loa (eye worm) IMP dehydrogenase 1 0.0229 0.2605 0.9868
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0165 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0026 0.0571
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0463 0.1778
Schistosoma mansoni inositol monophosphatase 0.0045 0.0463 0.1778
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.077 0.077
Schistosoma mansoni lamin 0.0033 0.0324 0.1242
Echinococcus multilocularis cpg binding protein 0.0032 0.0322 0.0322
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0229 0.2605 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0463 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0165 0.0627
Schistosoma mansoni ap endonuclease 0.0019 0.0167 0.0642
Schistosoma mansoni hypothetical protein 0.0015 0.0123 0.0472
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0167 0.3612
Loa Loa (eye worm) hypothetical protein 0.0015 0.0121 0.0459
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.062 0.2382
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0123 0.0237
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0186 0.0186
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0463 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0101 0.1121 0.4245
Trypanosoma cruzi GMP reductase 0.0229 0.2605 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0324 0.1226
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0167 0.0008
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0167 0.3612
Leishmania major guanosine monophosphate reductase 0.0229 0.2605 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0165 0.0627
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0101 0.1121 0.4302
Brugia malayi Inositol-1 0.0045 0.0463 0.1755
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0165 0.0635
Echinococcus granulosus muscleblind protein 0.018 0.2038 0.392
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0123 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0329 0.1245
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0165 0.0635
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.264 0.5076
Echinococcus granulosus neuropeptide s receptor 0.0453 0.52 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0165 0.0627
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0229 0.2605 1
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.52 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0034 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.0571
Schistosoma mansoni survival motor neuron protein 0.0047 0.0495 0.1901
Loa Loa (eye worm) hypothetical protein 0.0015 0.0121 0.0459
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0165 0.0635
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.52 0.52
Schistosoma mansoni inositol monophosphatase 0.0045 0.0463 0.1778
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0165 0.0165
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0302 0.1144
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0026 0.0571
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0128 0.0128
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0229 0.2605 0.9868

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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