Detailed information for compound 1279637

Basic information

Technical information
  • TDR Targets ID: 1279637
  • Name: 4-chloro-N-[(5-methyl-2-phenyl-1,3-oxazol-4-y l)methyl]benzenesulfonamide
  • MW: 362.831 | Formula: C17H15ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)NCc1nc(oc1C)c1ccccc1
  • InChi: 1S/C17H15ClN2O3S/c1-12-16(20-17(23-12)13-5-3-2-4-6-13)11-19-24(21,22)15-9-7-14(18)8-10-15/h2-10,19H,11H2,1H3
  • InChiKey: VPKVJSVBHAFUHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N-[(5-methyl-2-phenyl-oxazol-4-yl)methyl]benzenesulfonamide
  • 4-chloro-N-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzenesulfonamide
  • G373-0054
  • NCGC00130882-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0027 0.2613
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.2915
Loa Loa (eye worm) glutamate receptor 0.0039 0.0035 0.3396
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.003 1
Schistosoma mansoni hypothetical protein 0.004 0.0035 0.1161
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0074 0.0076 0.3111
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0009 0.0857
Brugia malayi hypothetical protein 0.0035 0.003 0.2912
Echinococcus granulosus metabotropic glutamate receptor 5 0.0048 0.0045 0.1805
Brugia malayi beta-lactamase 0.0035 0.003 0.2915
Loa Loa (eye worm) calpain family protein 1 0.0071 0.0072 0.7052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0586
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0074 0.0076 0.3242
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.2915
Brugia malayi beta-lactamase family protein 0.0035 0.003 0.2915
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0041 0.1438
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.003 1
Loa Loa (eye worm) glutamate receptor 0.0015 0.0006 0.0626
Loa Loa (eye worm) hypothetical protein 0.0071 0.0072 0.7052
Onchocerca volvulus 0.0035 0.003 0.1512
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0041 0.0373
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0102 1
Echinococcus granulosus geminin 0.0197 0.0221 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.003 0.0902
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.3623
Echinococcus multilocularis lamin 0.0033 0.0027 0.0217
Echinococcus multilocularis expressed conserved protein 0.009 0.0095 0.0961
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.4605
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0013 0.0069
Onchocerca volvulus 0.0035 0.003 0.1512
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0013 0.0107
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.003 0.2966
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.4451
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0041 0.1437
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0254 0.0225
Mycobacterium ulcerans AcrR family transcriptional regulator 0.8462 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0041 0.1437
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.8462 1 1
Schistosoma mansoni calpain (C02 family) 0.0021 0.0013 0.0107
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.2915
Schistosoma mansoni hypothetical protein 0.0197 0.0221 1
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0013 0.0295
Brugia malayi calpain 7 0.0021 0.0013 0.1276
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0013 0.0107
Brugia malayi CHE-14 protein 0.0041 0.0037 0.3623
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0027 0.0775
Echinococcus multilocularis hypothetical protein 0.0021 0.0013 0.0069
Echinococcus multilocularis calpain family protein 1, d 0.005 0.0047 0.0438
Echinococcus granulosus lamin dm0 0.0033 0.0027 0.0931
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0027 0.2613
Echinococcus multilocularis calpain 5 0.0021 0.0013 0.0069
Echinococcus granulosus calpain A 0.0074 0.0076 0.3242
Brugia malayi Metabotropic glutamate receptor precursor. 0.0039 0.0035 0.3396
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0074 0.0076 0.3111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0027 0.2613
Echinococcus multilocularis musashi 0.0033 0.0027 0.0217
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0009 0.0857
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0074 0.0076 0.0756
Echinococcus multilocularis lamin dm0 0.0033 0.0027 0.0217
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0037 0.0329
Loa Loa (eye worm) calpain 5 0.0021 0.0013 0.1276
Echinococcus granulosus expressed conserved protein 0.009 0.0095 0.4122
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.003 0.09
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0048 0.0045 0.0421
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.0072 0.2907
Echinococcus granulosus calpain A 0.0021 0.0013 0.0295
Echinococcus multilocularis geminin 0.0197 0.0221 0.2332
Echinococcus multilocularis protein dispatched 1 0.0047 0.0044 0.0404
Leishmania major hypothetical protein, conserved 0.0035 0.003 1
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.09
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.003 0.2915
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.0925 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0033 0.0027 0.0951
Brugia malayi calpain family protein 1 0.0071 0.0072 0.7052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.003 0.025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0656
Schistosoma mansoni patched 1 0.0041 0.0037 0.1245
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0104 0.4421
Loa Loa (eye worm) hypothetical protein 0.0051 0.0048 0.4702
Mycobacterium ulcerans TetR family transcriptional regulator 0.8462 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0041 0.4019
Loa Loa (eye worm) calpain family protein 1 0.005 0.0047 0.4605
Brugia malayi calpain family protein 1 0.0071 0.0072 0.7052
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0151 0.1568
Echinococcus multilocularis protein patched 0.0041 0.0037 0.0329
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0586
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0041 0.0373
Schistosoma mansoni hypothetical protein 0.004 0.0035 0.1161
Schistosoma mansoni hypothetical protein 0.004 0.0035 0.1161
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.1875
Loa Loa (eye worm) calpain 0.0021 0.0013 0.1276
Onchocerca volvulus 0.0035 0.003 0.1512
Echinococcus granulosus intermediate filament protein 0.0033 0.0027 0.0931
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.003 0.1073
Schistosoma mansoni hypothetical protein 0.004 0.0035 0.1161
Loa Loa (eye worm) hypothetical protein 0.0071 0.0072 0.7052
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.003 0.025
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.1875
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0013 0.0107
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0041 0.4019
Mycobacterium ulcerans transcriptional regulator 0.8462 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.003 0.2915
Echinococcus granulosus calpain 5 0.0021 0.0013 0.0295
Echinococcus multilocularis calpain A 0.0074 0.0076 0.0756
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.2915
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.4605
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.1875
Plasmodium vivax hypothetical protein, conserved 0.0035 0.003 1
Schistosoma mansoni lamin 0.0033 0.0027 0.0755
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.003 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.003 0.0902
Brugia malayi beta-lactamase family protein 0.0035 0.003 0.2915
Onchocerca volvulus 0.005 0.0047 1
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0151 0.6724
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0037 0.1411
Brugia malayi calpain 5 0.0021 0.0013 0.1276
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.2915
Loa Loa (eye worm) hypothetical protein 0.0096 0.0102 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0027 0.0755
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0041 0.1437
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.2544
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.003 0.1074
Schistosoma mansoni hypothetical protein 0.0197 0.0221 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.003 0.2915
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0041 0.16
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.2915
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.1875
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0041 0.16
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0102 0.1036
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0011 0.1055
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0037 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0037 0.3623
Schistosoma mansoni lamin 0.0033 0.0027 0.0755
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.2613
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0102 0.4444
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0033 0.0027 0.0222
Toxoplasma gondii ABC1 family protein 0.0035 0.003 0.5
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0037 0.1411
Echinococcus granulosus lamin 0.0033 0.0027 0.0931
Echinococcus granulosus calpain 0.0021 0.0013 0.0295
Brugia malayi intermediate filament protein 0.0033 0.0027 0.2613
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0013 0.0107
Echinococcus multilocularis calpain 0.0021 0.0013 0.0069

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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