Detailed information for compound 1293436

Basic information

Technical information
  • TDR Targets ID: 1293436
  • Name: methyl 4-[(Z,4R)-5-[(3-hydroxy-4-methoxypheny l)methylamino]-2-iodo-4-methyl-5-oxo-1-(pheny lmethoxycarbonylamino)pent-2-enyl]benzoate
  • MW: 658.481 | Formula: C30H31IN2O7
  • H donors: 3 H acceptors: 4 LogP: 5.3 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)c1ccc(cc1)C(/C(=C/[C@H](C(=O)NCc1ccc(c(c1)O)OC)C)/I)NC(=O)OCc1ccccc1
  • InChi: 1S/C30H31IN2O7/c1-19(28(35)32-17-21-9-14-26(38-2)25(34)16-21)15-24(31)27(22-10-12-23(13-11-22)29(36)39-3)33-30(37)40-18-20-7-5-4-6-8-20/h4-16,19,27,34H,17-18H2,1-3H3,(H,32,35)(H,33,37)/b24-15-/t19-,27?/m1/s1
  • InChiKey: YTJPPPNLZCLPRV-FAZXFUKLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 4-[(Z,4R)-5-[(3-hydroxy-4-methoxy-phenyl)methylamino]-2-iodo-4-methyl-5-oxo-1-(phenylmethoxycarbonylamino)pent-2-enyl]benzoate
  • 4-[(Z,4R)-5-[(3-hydroxy-4-methoxyphenyl)methylamino]-2-iodo-4-methyl-5-oxo-1-[[oxo-(phenylmethoxy)methyl]amino]pent-2-enyl]benzoic acid methyl ester
  • 4-[(Z,4R)-1-(benzyloxycarbonylamino)-5-[(3-hydroxy-4-methoxy-benzyl)amino]-2-iodo-5-keto-4-methyl-pent-2-enyl]benzoic acid methyl ester
  • CMLD4_000396
  • NCGC00092098-01
  • UPCMLD05AGHW001149
  • SDCCGMLS-0091284.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi isocitrate dehydrogenase 0.0018 0.0095 0.0075
Echinococcus granulosus tubulin polymerization promoting protein family 0.0026 0.0193 0.0747
Echinococcus granulosus tubulin polymerization promoting protein family 0.0026 0.0193 0.0747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1097 0.4657
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0095 0.0682
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.065 0.5
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0055 0.0055
Echinococcus granulosus geminin 0.0193 0.2333 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0021
Echinococcus multilocularis tubulin polymerization promoting protein family 0.0026 0.0193 0.0747
Echinococcus multilocularis GPCR, family 2 0.0018 0.0095 0.032
Schistosoma mansoni hypothetical protein 0.0039 0.0361 0.1473
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.065 0.2721
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0021 0.0021
Trypanosoma cruzi p25-alpha, putative 0.0026 0.0193 0.2334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0095 0.0075
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0095 0.0322
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.1097 0.1097
Trypanosoma brucei protein kinase, putative 0.0062 0.065 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0055 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1097 0.4657
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0095 0.0322
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0095 0.0682
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.065 1
Brugia malayi MH2 domain containing protein 0.0116 0.1343 0.1325
Brugia malayi Cytochrome P450 family protein 0.0015 0.0055 0.0034
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.065 1
Toxoplasma gondii p25-alpha family protein 0.0026 0.0193 0.1772
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.065 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0095 0.0682
Echinococcus multilocularis geminin 0.0193 0.2333 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0591 0.0591
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.032
Brugia malayi hypothetical protein 0.0345 0.4266 0.4254
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.065 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.065 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0095 0.0322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0591 0.0591
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0095 0.0095
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0021 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0095 0.0095
Echinococcus multilocularis tubulin polymerization promoting protein family 0.0026 0.0193 0.0747
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.065 0.2721
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0095 0.0322
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0095 0.032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0021 0.0021
Trypanosoma brucei p25-alpha, putative 0.0026 0.0193 0.2334
Schistosoma mansoni hypothetical protein 0.0193 0.2333 1
Loa Loa (eye worm) hypothetical protein 0.0345 0.4266 0.4266
Toxoplasma gondii hypothetical protein 0.0026 0.0193 0.1772
Onchocerca volvulus 0.0345 0.4266 0.4254
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1097 0.4657
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0021
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.065 0.2721
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0021 0.0021
Echinococcus granulosus tubulin polymerization promoting protein family 0.0026 0.0193 0.0747
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1097 0.4657
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0055 0.0055
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1343 0.1343
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0095 0.0682
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.1097 0.1079
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.065 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0095 0.0682
Leishmania major hypothetical protein, conserved 0.0026 0.0193 0.2334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0021 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0095 0.032
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.065 1
Schistosoma mansoni hypothetical protein 0.0026 0.0193 0.0747
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.065 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0055 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0095 0.032
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0095 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1097 0.4657
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0095 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0021 0.0021
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.065 0.5
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0021
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0095 0.5
Plasmodium vivax p25-alpha family protein, putative 0.0026 0.0193 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0095 0.0322
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0591 0.0572
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0095 0.0322
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0361 0.0341
Echinococcus granulosus tubulin polymerization promoting protein family 0.0026 0.0193 0.0747
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.065 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1343 0.1343
Brugia malayi Cytochrome P450 family protein 0.0015 0.0055 0.0034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0361 0.0361
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1097 0.4657
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0021
Schistosoma mansoni p25-alpha domain containing protein 0.0026 0.0193 0.0747
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.065 1
Leishmania major hypothetical protein, conserved 0.0026 0.0193 0.2334
Schistosoma mansoni P25 alpha-related 0.0026 0.0193 0.0747
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.032
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0095 0.0322
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.065 0.065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0591 0.0572
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.065 0.2721
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.065 0.5
Echinococcus multilocularis tubulin polymerization promoting protein family 0.0026 0.0193 0.0747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0021 0.0021
Treponema pallidum ATP-binding protein (ylxH-1) 0.0428 0.5331 0.5
Brugia malayi MAP kinase sur-1 0.0062 0.065 0.0631
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0021 0.0021
Echinococcus granulosus GPCR family 2 0.0018 0.0095 0.032
Schistosoma mansoni hypothetical protein 0.0193 0.2333 1
Trypanosoma cruzi p25-alpha, putative 0.0026 0.0193 0.2334
Plasmodium falciparum p25-alpha family protein, putative 0.0026 0.0193 1
Echinococcus multilocularis tubulin polymerization promoting protein family 0.0026 0.0193 0.0747
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.065 0.2721
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0095 0.0074
Toxoplasma gondii p25-alpha family protein 0.0026 0.0193 0.1772
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1097 0.4657

Activities

Activity type Activity value Assay description Source Reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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