Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acid phosphatase 1, soluble | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) | acid phosphatase 1, soluble | 112 aa | 107 aa | 24.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0268 | 0.0451 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.1704 | 0.3837 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0226 | 0.339 | 0.9814 |
Onchocerca volvulus | 0.0229 | 0.344 | 1 | |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.1704 | 0.3063 |
Onchocerca volvulus | 0.0226 | 0.339 | 0.9852 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0268 | 0.1483 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1704 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0046 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.0409 | 0.1141 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.1704 | 0.3837 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0268 | 0.0482 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0226 | 0.339 | 1 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.1704 | 0.3837 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0409 | 0.2316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1704 | 1 |
Leishmania major | hypothetical protein, conserved | 0.007 | 0.0716 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0226 | 0.339 | 0.9814 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0046 | 1 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0226 | 0.339 | 0.7675 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0521 | 0.1145 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0226 | 0.339 | 0.9814 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.1704 | 0.304 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0226 | 0.339 | 0.7675 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.1498 | 0.3369 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0521 | 0.2985 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0226 | 0.339 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.1704 | 0.3837 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0409 | 0.0889 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.1498 | 0.3369 |
Brugia malayi | hypothetical protein | 0.0286 | 0.4411 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0521 | 0.2985 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0716 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.2965 | 0.6709 |
Onchocerca volvulus | 0.0058 | 0.0521 | 0.147 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1704 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.2965 | 0.6709 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0268 | 0.1483 |
Brugia malayi | RNA binding protein | 0.0127 | 0.1704 | 0.3837 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.1704 | 0.3837 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0716 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.4411 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0353 | 0.5563 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.1498 | 0.3369 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1704 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0046 | 0.0062 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0046 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.4411 | 0.7929 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.4411 | 0.7922 |
Echinococcus multilocularis | tumor protein p63 | 0.0353 | 0.5563 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0046 | 0.0062 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.344 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1704 | 1 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.007 | 0.0716 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0046 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0226 | 0.339 | 0.9814 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0018 | 0.0033 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0226 | 0.339 | 0.9814 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0226 | 0.339 | 0.9814 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0268 | 0.0569 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0226 | 0.339 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 7.44 uM | PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 11.9 uM | PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 80 uM | PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in a fluorescence-based, Lymphoid Phosphatase (PTPN22, LYP-1) selectivity Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7519 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.