Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Lethal(3)malignant brain tumor-like 4 protein, putative | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Schistosoma japonicum | Lethal(3)malignant brain tumor-like 3 protein, putative | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.3809 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0066 | 0.0273 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0273 | 0.0716 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0066 | 0.0273 | 0.0273 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0066 | 0.0273 | 0.0471 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0169 | 0.3809 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0066 | 0.0273 | 0.0471 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0066 | 0.0273 | 0.0471 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0227 | 0.579 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0066 | 0.0273 | 0.0471 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0066 | 0.0273 | 0.0716 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0227 | 0.579 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0169 | 0.3809 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.