Detailed information for compound 1303685

Basic information

Technical information
  • TDR Targets ID: 1303685
  • Name: N-[4-(phenylmethylsulfamoyl)phenyl]formamide
  • MW: 290.338 | Formula: C14H14N2O3S
  • H donors: 2 H acceptors: 3 LogP: 2.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CNc1ccc(cc1)S(=O)(=O)NCc1ccccc1
  • InChi: 1S/C14H14N2O3S/c17-11-15-13-6-8-14(9-7-13)20(18,19)16-10-12-4-2-1-3-5-12/h1-9,11,16H,10H2,(H,15,17)
  • InChiKey: JQFZAAAPKBBALU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(benzylsulfamoyl)phenyl]formamide
  • N-[4-(phenylmethylsulfamoyl)phenyl]methanamide
  • ZINC00462950
  • N-benzyl-4-(formylamino)benzenesulfonamide
  • SMR000136349
  • MLS000531371

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.013 0.6448 1
Echinococcus multilocularis lamin 0.003 0.1291 0.1911
Echinococcus granulosus 6 phosphofructokinase 0.013 0.6448 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.1532 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.1532 0.2288
Trichomonas vaginalis phosphofructokinase, putative 0.013 0.6448 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.1532 0.2288
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0277 0.1807
Loa Loa (eye worm) hypothetical protein 0.0014 0.0445 0.0375
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0218 0.0146
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0218 0.0228
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.1532 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Echinococcus granulosus intermediate filament protein 0.003 0.1291 0.1911
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.013 0.6448 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2547 0.388
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0277 0.0205
Onchocerca volvulus 0.003 0.1291 0.1227
Onchocerca volvulus 0.003 0.1291 0.1227
Loa Loa (eye worm) intermediate filament protein 0.003 0.1291 0.1227
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.1532 0.2376
Brugia malayi 6-phosphofructokinase 0.013 0.6448 0.6422
Echinococcus granulosus lamin 0.003 0.1291 0.1911
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0218 0.0228
Entamoeba histolytica phosphofructokinase, putative 0.013 0.6448 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0626 0.4088
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0218 0.0146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2547 0.395
Schistosoma mansoni dishevelled 0.001 0.0218 0.0339
Brugia malayi intermediate filament protein 0.003 0.1291 0.1227
Loa Loa (eye worm) phosphofructokinase 0.013 0.6448 0.6422
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.1291 0.1227
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.013 0.6448 1
Schistosoma mansoni DNA helicase recq1 0.0011 0.0277 0.0429
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Brugia malayi 6-phosphofructokinase 0.013 0.6448 0.6422
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0474 0.0629
Leishmania major ATP-dependent phosphofructokinase 0.013 0.6448 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Loa Loa (eye worm) RecQ helicase 0.0026 0.108 0.1014
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0218 0.0228
Loa Loa (eye worm) hypothetical protein 0.0015 0.0474 0.0404
Mycobacterium ulcerans 6-phosphofructokinase 0.013 0.6448 0.5
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.1532 1
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.1532 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0445 0.0375
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.1532 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0277 0.1807
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0218 0.0228
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0218 0.0228
Brugia malayi phosphofructokinase 0.013 0.6448 0.6422
Loa Loa (eye worm) 6-phosphofructokinase 0.013 0.6448 0.6422
Loa Loa (eye worm) hypothetical protein 0.0133 0.6598 0.6573
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0218 0.0339
Entamoeba histolytica phosphofructokinase, putative 0.013 0.6448 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.013 0.6448 0.5
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0218 0.0146
Schistosoma mansoni intermediate filament proteins 0.003 0.1291 0.2003
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.1532 0.2288
Toxoplasma gondii hypothetical protein 0.001 0.0218 0.1426
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0277 0.032
Echinococcus multilocularis lamin dm0 0.003 0.1291 0.1911
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.1532 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2547 0.395
Echinococcus multilocularis 6 phosphofructokinase 0.013 0.6448 1
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0218 0.0228
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0218 0.0146
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.1532 0.5
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0558 0.0489
Schistosoma mansoni lamin 0.003 0.1291 0.2003
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 1 1
Schistosoma mansoni dep domain containing protein 0.001 0.0218 0.0339
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.1532 1
Trichomonas vaginalis phosphofructokinase, putative 0.013 0.6448 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0277 0.032
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.1532 0.2376
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.013 0.6448 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0218 0.0146
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0218 0.0228
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0218 0.0146
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.1532 0.2288
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0443 0.058
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0218 0.0228
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0443 0.058
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0218 0.0228
Entamoeba histolytica hypothetical protein 0.0007 0.0073 0.0113
Loa Loa (eye worm) hypothetical protein 0.001 0.0218 0.0146
Loa Loa (eye worm) hypothetical protein 0.0011 0.0277 0.0205
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2547 0.2492
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0073 0.0113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2547 0.388
Echinococcus granulosus bloom syndrome protein 0.0026 0.108 0.158
Entamoeba histolytica phosphofructokinase, putative 0.013 0.6448 1
Loa Loa (eye worm) hypothetical protein 0.0199 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.1532 0.2288
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.108 0.158
Trichomonas vaginalis phosphofructokinase, putative 0.013 0.6448 1
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0443 0.0687
Loa Loa (eye worm) 6-phosphofructokinase 0.013 0.6448 0.6422
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0792 0.1229
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2547 0.2492
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0474 0.0629
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0218 0.0339
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0073 0.0113
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0073 0.0113
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.1532 0.5
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0277 0.0205
Schistosoma mansoni DNA helicase recq5 0.0011 0.0277 0.0429
Echinococcus granulosus lamin dm0 0.003 0.1291 0.1911
Schistosoma mansoni dishevelled 0.001 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.003 0.1262 0.1198
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.0055 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.013 0.6448 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0277 0.032
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0073 0.0113
Onchocerca volvulus 0.001 0.0218 0.0146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2547 0.388
Schistosoma mansoni 6-phosphofructokinase 0.013 0.6448 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.1532 0.2288
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0073 0.0113
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.108 0.158
Brugia malayi DIX domain containing protein 0.001 0.0218 0.0146
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Brugia malayi hypothetical protein 0.001 0.0218 0.0146
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0073 0.0113
Loa Loa (eye worm) hypothetical protein 0.001 0.0218 0.0146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2547 0.388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2547 0.395
Echinococcus multilocularis musashi 0.003 0.1291 0.1911
Brugia malayi hypothetical protein 0.001 0.0218 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.1532 0.2288
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0914 0.5077
Schistosoma mansoni 6-phosphofructokinase 0.013 0.6448 1
Schistosoma mansoni lamin 0.003 0.1291 0.2003
Echinococcus multilocularis bloom syndrome protein 0.0026 0.108 0.158
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0277 0.032
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.1291 0.1227
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0218 0.0146
Schistosoma mansoni regulator of G protein signaling 0.001 0.0218 0.0339
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0218 0.0228
Loa Loa (eye worm) hypothetical protein 0.003 0.1291 0.1227
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0277 0.0205
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0558 0.0489
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.108 0.1014
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.1532 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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