Detailed information for compound 1304846

Basic information

Technical information
  • TDR Targets ID: 1304846
  • Name: 2-[3-[(4-methylphenyl)methyl]quinoxalin-2-yl] sulfanyl-1-(2-methylpiperidin-1-yl)ethanone
  • MW: 405.556 | Formula: C24H27N3OS
  • H donors: 0 H acceptors: 3 LogP: 5.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Cc1nc2ccccc2nc1SCC(=O)N1CCCCC1C
  • InChi: 1S/C24H27N3OS/c1-17-10-12-19(13-11-17)15-22-24(26-21-9-4-3-8-20(21)25-22)29-16-23(28)27-14-6-5-7-18(27)2/h3-4,8-13,18H,5-7,14-16H2,1-2H3
  • InChiKey: NEILHLGNPDRCIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[3-[(4-methylphenyl)methyl]quinoxalin-2-yl]sulfanyl-1-(2-methyl-1-piperidyl)ethanone
  • 2-[[3-[(4-methylphenyl)methyl]-2-quinoxalinyl]thio]-1-(2-methyl-1-piperidinyl)ethanone
  • 2-[[3-(4-methylbenzyl)quinoxalin-2-yl]thio]-1-(2-methyl-1-piperidyl)ethanone
  • G766-1452
  • NCGC00133787-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0073 0.0085
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1509 0.3638
Echinococcus granulosus tar DNA binding protein 0.0067 0.0639 0.0753
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.013 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0639 0.0753
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0073 0.0073
Echinococcus multilocularis geminin 0.0188 0.2002 0.2002
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0073 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0379 0.4148 0.4883
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0076 0.0076
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0294 0.3191 0.9661
Schistosoma mansoni hypothetical protein 0.0188 0.2002 0.2358
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0042 0.0359 0.0722
Mycobacterium ulcerans glutaminase 0.0303 0.3298 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0352 0.0848
Trypanosoma brucei unspecified product 0.0021 0.013 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0073 0.0085
Echinococcus granulosus expressed protein 0.0016 0.0073 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0639 0.0753
Loa Loa (eye worm) RNA binding protein 0.0067 0.0639 0.1542
Plasmodium falciparum ornithine aminotransferase 0.0042 0.0359 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0104 0.0104
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0073 0.0175
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0042 0.0359 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.013 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Echinococcus granulosus Aminotransferase class III 0.0042 0.0359 0.0423
Echinococcus multilocularis microtubule associated protein 2 0.0766 0.8494 0.8494
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0073 0.0085
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0073 0.0175
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.013 0.0314
Brugia malayi G-protein alpha subunit 0.0016 0.0073 0.0175
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0175
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0073 0.0085
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0073 0.0073
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0073 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0073 0.0175
Schistosoma mansoni glutaminase 0.0303 0.3298 0.3883
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0104 0.0122
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.013 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.013 0.0174
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0076 0.0076
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0042 0.0359 0.0865
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.013 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0566 0.1364
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0076 0.2737
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0073 0.0085
Echinococcus granulosus microtubule associated protein 2 0.0766 0.8494 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0379 0.4148 0.4883
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0042 0.0359 0.0722
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0379 0.4148 0.4148
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0073 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0639 0.0753
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0073 0.0175
Echinococcus multilocularis ornithine aminotransferase 0.0042 0.0359 0.0359
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1509 0.3638
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0042 0.0359 0.5
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0042 0.0359 0.0722
Schistosoma mansoni microtubule-associated protein tau 0.0766 0.8494 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.013 0.0314
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.013 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0566 0.1364
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0076 0.0076
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0073 0.0073
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0639 0.1542
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0379 0.4148 0.4148
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.013 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0352 0.0848
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0639 0.0753
Loa Loa (eye worm) hypothetical protein 0.019 0.2019 0.4868
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.013 0.0153
Loa Loa (eye worm) pax transcription factor protein 2 0.0239 0.2569 0.6193
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.013 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0379 0.4148 1
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0073 0.0175
Loa Loa (eye worm) hypothetical protein 0.006 0.0566 0.1364
Echinococcus granulosus ornithine aminotransferase 0.0042 0.0359 0.0423
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0104 0.025
Echinococcus granulosus GPCR family 2 0.0019 0.0104 0.0122
Onchocerca volvulus 0.0239 0.2569 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0175
Giardia lamblia DINP protein human, muc B family 0.0021 0.013 0.5
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0073 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0175
Brugia malayi N-terminal motif family protein 0.019 0.2019 0.4868
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0379 0.4148 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0073 0.0085
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0073 0.0085
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.013 1
Mycobacterium ulcerans hypothetical protein 0.0294 0.3191 0.9661
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0042 0.0359 0.5
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0042 0.0359 0.0722
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0639 0.1542
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0073 0.0175
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0294 0.3191 1
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0639 0.1542
Brugia malayi hypothetical protein 0.0016 0.0073 0.0175
Schistosoma mansoni hypothetical protein 0.0019 0.0104 0.0122
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0073 0.0175
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.013 0.0174
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0104 0.0104
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0073 0.0085
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0076 0.2737
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0042 0.0359 0.0908
Loa Loa (eye worm) glutaminase 0.0303 0.3298 0.7951
Schistosoma mansoni hypothetical protein 0.0019 0.0104 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0379 0.4148 0.4883
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0073 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0076 0.009
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.013 0.0179
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0073 0.0175
Plasmodium vivax ornithine aminotransferase, putative 0.0042 0.0359 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0379 0.4148 0.4883
Echinococcus multilocularis ornithine aminotransferase 0.0042 0.0359 0.0359
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0073 0.0085
Echinococcus multilocularis expressed protein 0.0016 0.0073 0.0073
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0042 0.0359 0.0908
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0073 0.0175
Leishmania major DNA polymerase kappa, putative 0.0021 0.013 1
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0042 0.0359 0.0908
Loa Loa (eye worm) glutaminase 2 0.0303 0.3298 0.7951
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0104 0.025
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0042 0.0359 0.0908
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.013 1
Brugia malayi MH2 domain containing protein 0.0144 0.1509 0.3638
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0073 0.0085
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0042 0.0359 0.0423
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0073 0.0175
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0073 0.0175
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0073 0.0085
Brugia malayi Pax transcription factor protein 2 0.0239 0.2569 0.6193
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0104 0.0122
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0073 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0639 0.0753
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0073 0.0085
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0104 0.025
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.013 0.0179
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0294 0.3191 1
Brugia malayi RNA binding protein 0.0067 0.0639 0.1542
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0566 0.1364
Schistosoma mansoni hypothetical protein 0.0019 0.0104 0.0122
Mycobacterium tuberculosis Probable aminotransferase 0.0294 0.3191 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0019 0.0104 0.0122
Echinococcus multilocularis Aminotransferase class III 0.0042 0.0359 0.0359
Schistosoma mansoni hypothetical protein 0.0188 0.2002 0.2358
Trichomonas vaginalis glutaminase, putative 0.0303 0.3298 1
Brugia malayi TAR-binding protein 0.0067 0.0639 0.1542
Schistosoma mansoni hypothetical protein 0.0041 0.0352 0.0414
Brugia malayi glutaminase DH11.1 0.0303 0.3298 0.7951
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0073 0.0085
Echinococcus granulosus dna polymerase kappa 0.0021 0.013 0.0153
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.013 0.0314
Mycobacterium ulcerans acetylornithine aminotransferase 0.0042 0.0359 0.0722
Echinococcus granulosus dna polymerase eta 0.0021 0.013 0.0153
Echinococcus multilocularis dna polymerase kappa 0.0021 0.013 0.013
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0294 0.3191 0.9667
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0104 0.0104
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.013 0.013
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.2019 0.7799
Schistosoma mansoni DNA polymerase eta 0.0021 0.013 0.0153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0076 0.0076
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0076 0.0183
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0073 0.0085
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0073 0.0175
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0076 0.009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0379 0.4148 0.4883
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.013 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.013 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.013 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0076 0.0183
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.013 1
Leishmania major DNA polymerase eta, putative 0.0021 0.013 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0104 0.025
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0639 0.0639
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0175
Brugia malayi isocitrate dehydrogenase 0.0017 0.0076 0.0183
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.013 1
Echinococcus multilocularis dna polymerase eta 0.0021 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0175
Mycobacterium ulcerans L-lysine aminotransferase 0.0042 0.0359 0.0722
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.013 0.0314
Echinococcus granulosus geminin 0.0188 0.2002 0.2358

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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