Detailed information for compound 1308569

Basic information

Technical information
  • TDR Targets ID: 1308569
  • Name: 2-(1-ethyl-2-oxoquinolin-4-yl)oxy-N-(5-methyl pyridin-2-yl)acetamide
  • MW: 337.372 | Formula: C19H19N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(=O)cc(c2c1cccc2)OCC(=O)Nc1ccc(cn1)C
  • InChi: 1S/C19H19N3O3/c1-3-22-15-7-5-4-6-14(15)16(10-19(22)24)25-12-18(23)21-17-9-8-13(2)11-20-17/h4-11H,3,12H2,1-2H3,(H,20,21,23)
  • InChiKey: MAJKLHMTAPVCPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(1-ethyl-2-oxo-4-quinolyl)oxy]-N-(5-methyl-2-pyridyl)acetamide
  • 2-[(1-ethyl-2-keto-4-quinolyl)oxy]-N-(5-methyl-2-pyridyl)acetamide
  • 2-(1-ethyl-2-oxo-quinolin-4-yl)oxy-N-(5-methylpyridin-2-yl)ethanamide
  • 2-[(1-ethyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(5-methylpyridin-2-yl)acetamide
  • MLS000089555
  • SMR000027903

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0072 0.0276 0.026
Loa Loa (eye worm) hexokinase 0.1208 0.8721 0.8721
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0977 0.7004 0.8019
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0199 0.0199
Schistosoma mansoni 6-phosphogluconolactonase 0.0042 0.0051 0.0051
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0477 0.3285 0.373
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.1019 0.7315 0.8363
Schistosoma mansoni hexokinase 0.1208 0.8721 0.8721
Schistosoma mansoni caspase-3 (C14 family) 0.0196 0.1198 0.1198
Loa Loa (eye worm) hexokinase 0.1208 0.8721 0.8721
Schistosoma mansoni caspase-7 (C14 family) 0.0052 0.0129 0.0129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0096 0.0053
Onchocerca volvulus 0.1208 0.8721 1
Trypanosoma brucei hexokinase 0.1208 0.8721 1
Mycobacterium ulcerans glutaminase 0.138 1 1
Trypanosoma cruzi metacaspase, putative 0.0052 0.0129 0.0091
Trypanosoma brucei polo-like protein kinase 0.0477 0.3285 0.373
Onchocerca volvulus Serine\/threonine kinase homolog 0.0477 0.3285 0.3673
Plasmodium vivax hexokinase, putative 0.1208 0.8721 1
Mycobacterium ulcerans hypothetical protein 0.0124 0.0659 0.0611
Trypanosoma brucei beta lactamase 0.013 0.0703 0.0753
Brugia malayi RNA binding protein 0.0062 0.0199 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0096 0.0096
Echinococcus granulosus hexokinase type 2 0.1208 0.8721 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0477 0.3285 0.373
Echinococcus granulosus hexokinase 0.1208 0.8721 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0477 0.3285 0.3285
Onchocerca volvulus 0.1208 0.8721 1
Entamoeba histolytica hexokinase 2 0.1208 0.8721 1
Echinococcus granulosus hexokinase 0.1208 0.8721 1
Trichomonas vaginalis CAMK family protein kinase 0.0236 0.1494 0.1451
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0129 0.0079
Trypanosoma cruzi metacaspase, putative 0.0052 0.0129 0.0091
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0477 0.3285 0.3285
Schistosoma mansoni serine/threonine protein kinase 0.0477 0.3285 0.3285
Brugia malayi hexokinase type II 0.0384 0.2595 0.2595
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0129 0.0079
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0129 0.0079
Echinococcus granulosus citrate lyase subunit beta protein 0.0124 0.0659 0.0701
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0124 0.0659 0.0611
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.1019 0.7315 1
Giardia lamblia Kinase, PLK 0.0477 0.3285 0.4452
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0977 0.7004 0.8019
Trypanosoma cruzi hypothetical protein, conserved 0.1074 0.7724 0.885
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0124 0.0659 0.0611
Trypanosoma brucei metacaspase MCA3 0.0052 0.0129 0.0091
Mycobacterium ulcerans hypothetical protein 0.0124 0.0659 0.0611
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0199 0.0199
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0977 0.7004 0.7004
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0129 0.0079
Echinococcus granulosus caspase 3 0.0144 0.0808 0.0874
Trichomonas vaginalis CAMK family protein kinase 0.0477 0.3285 0.325
Echinococcus multilocularis hexokinase 0.1208 0.8721 1
Brugia malayi glucose-6-phosphate dehydrogenase 0.0977 0.7004 0.7004
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0199 0.0199
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0129 0.0079
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0124 0.0659 0.0701
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0129 0.0079
Echinococcus granulosus hexokinase 0.1208 0.8721 1
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0042 0.0051 0.0051
Trypanosoma brucei metacaspase 5, putative 0.0052 0.0129 0.0091
Loa Loa (eye worm) hexokinase 0.0758 0.5374 0.5374
Echinococcus granulosus caspase 2 0.0052 0.0129 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0129 0.0079
Schistosoma mansoni hypothetical protein 0.0072 0.0276 0.0276
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0276 0.026
Trypanosoma cruzi hypothetical protein, conserved 0.1074 0.7724 0.885
Echinococcus multilocularis caspase 2 0.0052 0.0129 0.0091
Schistosoma mansoni kinase 0.0242 0.1541 0.1541
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0121 0.0121
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0977 0.7004 0.8019
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0384 0.2595 0.2595
Trichomonas vaginalis CAMK family protein kinase 0.0477 0.3285 0.325
Entamoeba histolytica serine/threonine protein kinase, putative 0.0477 0.3285 0.373
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0977 0.7004 0.6988
Entamoeba histolytica hypothetical protein 0.0072 0.0276 0.026
Brugia malayi MH2 domain containing protein 0.0477 0.3288 0.3288
Echinococcus multilocularis citrate lyase subunit beta protein 0.0124 0.0659 0.0701
Leishmania major hexokinase, putative 0.1208 0.8721 1
Plasmodium falciparum hexokinase 0.1208 0.8721 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0052 0.0129 0.0129
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0042 0.0051 0.0051
Echinococcus granulosus tar DNA binding protein 0.0062 0.0199 0.0171
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0129 0.0079
Loa Loa (eye worm) transcription factor SMAD2 0.0477 0.3288 0.3288
Mycobacterium ulcerans lipoprotein LpqF 0.013 0.0703 0.0656
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.1019 0.7315 0.8363
Trichomonas vaginalis glutaminase, putative 0.138 1 1
Toxoplasma gondii hexokinase 0.1208 0.8721 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0196 0.1198 0.1324
Trichomonas vaginalis CAMK family protein kinase 0.0477 0.3285 0.325
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.027 0.1748 0.6808
Loa Loa (eye worm) glutaminase 2 0.138 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.0196 0.1198 0.1198
Brugia malayi hypothetical protein 0.0072 0.0276 0.0276
Brugia malayi Hexokinase family protein 0.0758 0.5374 0.5374
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0339 0.2259 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0199 0.0199
Trypanosoma brucei metacaspase 0.0052 0.0129 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0096 0.0096
Trypanosoma cruzi metacaspase, putative 0.0052 0.0129 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0129 0.0079
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0638 0.4484 0.4455
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0124 0.0659 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0129 0.0079
Trypanosoma cruzi hexokinase, putative 0.1208 0.8721 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0096 0.0096
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0977 0.7004 0.8019
Trichomonas vaginalis CAMK family protein kinase 0.0477 0.3285 0.325
Trichomonas vaginalis CAMK family protein kinase 0.0477 0.3285 0.325
Brugia malayi TAR-binding protein 0.0062 0.0199 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0236 0.1494 0.1451
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0977 0.7004 0.8019
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.013 0.0703 1
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.013 0.0703 0.028
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0129 0.0091
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0977 0.7004 0.7004
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0196 0.1198 0.1324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0096 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0477 0.3285 0.325
Trypanosoma cruzi metacaspase, putative 0.0052 0.0129 0.0091
Echinococcus multilocularis hexokinase type 2 0.1208 0.8721 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.1019 0.7315 0.8363
Trichomonas vaginalis CAMK family protein kinase 0.0477 0.3285 0.325
Loa Loa (eye worm) hexokinase type II 0.1208 0.8721 0.8721
Echinococcus multilocularis caspase 3 0.0144 0.0808 0.0874
Brugia malayi hexokinase 0.1208 0.8721 0.8721
Loa Loa (eye worm) MH2 domain-containing protein 0.0477 0.3288 0.3288
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1019 0.7315 0.7301
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0124 0.0659 0.0611
Echinococcus multilocularis hexokinase 0.1208 0.8721 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0096 0.0053
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0129 0.0079
Loa Loa (eye worm) glutaminase 0.138 1 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0199 0.0171
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0124 0.0659 0.0611
Brugia malayi Hexokinase family protein 0.1208 0.8721 0.8721
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0129 0.0079
Entamoeba histolytica hypothetical protein 0.0072 0.0276 0.026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0121 0.0121
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0276 0.026
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0314 0.2076 0.2336
Entamoeba histolytica hypothetical protein 0.0072 0.0276 0.026
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0199 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0129 0.0079
Onchocerca volvulus 0.0758 0.5374 0.6104
Schistosoma mansoni glutaminase 0.138 1 1
Treponema pallidum hexokinase (hxk) 0.1208 0.8721 1
Echinococcus granulosus caspase 8 0.0052 0.0129 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0199 0.0199
Onchocerca volvulus Hexokinase homolog 0.0758 0.5374 0.6104
Loa Loa (eye worm) hypothetical protein 0.0052 0.0129 0.0129
Onchocerca volvulus 0.1208 0.8721 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7019 0.8036
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1019 0.7315 0.7301
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0324 0.2146 0.2417
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0977 0.7004 0.8019
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.027 0.1748 0.1706
Echinococcus multilocularis caspase 8 0.0052 0.0129 0.0091
Entamoeba histolytica hexokinase 1 0.1208 0.8721 1
Trypanosoma brucei hexokinase, putative 0.1208 0.8721 1
Echinococcus multilocularis hexokinase 0.1208 0.8721 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0477 0.3285 0.373
Loa Loa (eye worm) hypothetical protein 0.0052 0.0129 0.0129
Trypanosoma brucei metacaspase MCA2 0.0052 0.0129 0.0091
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0124 0.0659 0.0701
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0276 0.0276
Leishmania major hexokinase, putative 0.1208 0.8721 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2595 0.2595
Echinococcus granulosus caspase 0.0196 0.1198 0.1324
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0129 0.0091
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0477 0.3285 0.373
Trypanosoma brucei hexokinase 0.1208 0.8721 1
Brugia malayi Cell death protein 3 precursor 0.0052 0.0129 0.0129
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0129 0.0079
Leishmania major hypothetical protein, conserved 0.1074 0.7724 0.885
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0638 0.4484 0.5068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0096 0.0053
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.1019 0.7315 0.7301
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0121 0.0121
Leishmania major metacaspase, putative 0.0052 0.0129 0.0091
Echinococcus multilocularis caspase 0.0196 0.1198 0.1324
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0096 0.0096
Schistosoma mansoni 6-phosphogluconolactonase 0.0042 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0051 0.0121 0.0121
Brugia malayi Hexokinase family protein 0.0374 0.2518 0.2518
Brugia malayi 6-phosphogluconolactonase family protein 0.0042 0.0051 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0096 0.0096
Trypanosoma brucei Metacaspase-4 0.0052 0.0129 0.0091
Trypanosoma cruzi hexokinase, putative 0.1208 0.8721 1
Trypanosoma brucei hypothetical protein, conserved 0.1074 0.7724 0.885
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0199 0.0199
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0199 0.0199
Trypanosoma cruzi polo-like protein kinase, putative 0.0477 0.3285 0.373
Loa Loa (eye worm) hypothetical protein 0.0824 0.5865 0.5865
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0052 0.0129 0.0129
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0977 0.7004 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0129 0.0079
Loa Loa (eye worm) hexokinase 0.0374 0.2518 0.2518

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.6626 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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