Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0135 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0135 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1452 | 0.141 |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0135 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0135 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1452 | 0.1452 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1403 | 0.1403 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0194 | 0.0194 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0135 | 1 | 0.5 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0135 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1452 | 0.1452 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.3969 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) | 0.0088 | 0.6074 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.3969 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.6392 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0047 | 0.2667 | 1 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0135 | 1 | 0.5 |
Onchocerca volvulus | 0.0047 | 0.2667 | 1 | |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1452 | 0.141 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0135 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1452 | 0.1283 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0135 | 1 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.4845 | 0.4819 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0135 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.1452 | 0.141 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0135 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1452 | 0.1283 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.0088 | 0.6074 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1452 | 0.141 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0135 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.005 | 0.005 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) | 0.0088 | 0.6074 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1452 | 0.141 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0047 | 0.2667 | 0.2522 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0047 | 0.2667 | 0.2522 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2667 | 0.2667 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2667 | 0.2667 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1452 | 0.1452 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.4845 | 0.4819 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0135 | 1 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0135 | 1 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0135 | 1 | 0.5 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.0088 | 0.6074 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1452 | 0.141 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.3115 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.