Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1452 | 0.141 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.3969 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0135 | 1 | 1 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0135 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.3969 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) | 0.0088 | 0.6074 | 1 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0135 | 1 | 0.5 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0135 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.6392 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0135 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.4845 | 0.4819 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.0088 | 0.6074 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1403 | 0.1403 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0047 | 0.2667 | 0.2522 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1452 | 0.141 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1452 | 0.141 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0047 | 0.2667 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0135 | 1 | 0.5 |
Onchocerca volvulus | 0.0047 | 0.2667 | 1 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1452 | 0.1452 |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0135 | 1 | 1 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.0088 | 0.6074 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.4845 | 0.4819 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1452 | 0.1283 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.005 | 0.005 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0194 | 0.0194 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0135 | 1 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0135 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0135 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1452 | 0.1452 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0135 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1452 | 0.141 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0135 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.1452 | 0.141 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2667 | 0.2667 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) | 0.0088 | 0.6074 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0047 | 0.2667 | 0.2522 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2667 | 0.2667 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1452 | 0.1452 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1452 | 0.141 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0135 | 1 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0135 | 1 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0135 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1452 | 0.1283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.3115 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.