Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0135 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0.2667 | 1 | |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0135 | 1 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) | 0.0088 | 0.6074 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2667 | 0.2667 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1452 | 0.1283 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0135 | 1 | 1 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0135 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.1452 | 0.141 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2667 | 0.2667 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.4845 | 0.4819 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0135 | 1 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1452 | 0.141 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1452 | 0.141 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0047 | 0.2667 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0135 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1403 | 0.1403 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1452 | 0.1452 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1452 | 0.1452 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1452 | 0.141 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0194 | 0.0194 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.0088 | 0.6074 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0047 | 0.2667 | 0.2522 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0135 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1452 | 0.1283 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) | 0.0088 | 0.6074 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0135 | 1 | 0.5 |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0135 | 1 | 1 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0135 | 1 | 0.5 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0135 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.3969 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0135 | 1 | 0.5 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1452 | 0.141 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0135 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0135 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.4845 | 0.4819 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1452 | 0.141 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0047 | 0.2667 | 0.2522 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.005 | 0.005 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.6392 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.3969 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.4845 | 0.297 |
Mycobacterium leprae | 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) | 0.0088 | 0.6074 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1452 | 0.1452 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.3115 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.