pI: 7.4517 |
Length (AA): 470 |
MW (Da): 49571 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 468 | 2hg4 (A) | 26 | 456 | 24.00 | 0 | 1 | 1.14 | -0.44 |
13 | 466 | 2gqd (A) | 4 | 413 | 39.00 | 0 | 1 | 1.35 | -1.19 |
14 | 465 | 1w0i (A) | 31 | 461 | 45.00 | 0 | 1 | 1.54 | -1.17 |
6 | 465 | 4c72 (A) | 9 | 416 | 33.00 | 0.0000000072 | 1 | 1.21902 | 0.37 |
14 | 465 | 2ix4 (A) | 31 | 461 | 47.00 | 0 | 1 | 1.5133 | -0.62 |
14 | 465 | 1j3n (A) | 2 | 408 | 45.00 | 0 | 1 | 1.4333 | -0.52 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | epimastigote. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_126985)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G04540 | 3-oxoacyl-[acyl-carrier-protein] synthase |
Arabidopsis thaliana | AT1G74960 | 3-oxoacyl-[acyl-carrier-protein] synthase II |
Arabidopsis thaliana | AT5G46290 | beta-ketoacyl-[acyl carrier protein] synthase I |
Brugia malayi | Bm1_36100 | Beta-ketoacyl synthase, N-terminal domain containing protein |
Candida albicans | CaO19.13398 | potential beta-keto-acyl synthase similar to S. cerevisiae CEM1 (YER061C) mitochondrial enzyme involved in hexadecanal biosynthe |
Candida albicans | CaO19.5977 | potential beta-keto-acyl synthase similar to S. cerevisiae CEM1 (YER061C) mitochondrial enzyme involved in hexadecanal biosynthe |
Caenorhabditis elegans | CELE_F10G8.9 | Protein F10G8.9, isoform A |
Cryptosporidium hominis | Chro.40326 | hypothetical protein |
Chlamydia trachomatis | CT_770 | 3-oxoacyl-ACP synthase |
Dictyostelium discoideum | DDB_G0275269 | hypothetical protein |
Drosophila melanogaster | Dmel_CG12170 | CG12170 gene product from transcript CG12170-RA |
Escherichia coli | b1095 | 3-oxoacyl-[acyl-carrier-protein] synthase II |
Echinococcus granulosus | EgrG_000839600 | 3 oxoacyl acyl carrier protein synthase |
Echinococcus multilocularis | EmuJ_000839600 | 3 oxoacyl (acyl carrier protein) synthase |
Homo sapiens | ENSG00000151093 | 3-oxoacyl-ACP synthase, mitochondrial |
Leishmania braziliensis | LbrM.33.3000 | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative |
Leishmania donovani | LdBPK_332860.1 | beta-ketoacyl synthase family protein, putative |
Leishmania infantum | LinJ.33.2860 | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative |
Leishmania major | LmjF.33.2720 | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative |
Leishmania mexicana | LmxM.32.2720 | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative |
Loa Loa (eye worm) | LOAG_05714 | beta-ketoacyl synthase domain-containing protein |
Mycobacterium leprae | ML1655 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) |
Mycobacterium leprae | ML1656 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) |
Mus musculus | ENSMUSG00000021786 | 3-oxoacyl-ACP synthase, mitochondrial |
Mycobacterium tuberculosis | Rv2245 | 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) |
Mycobacterium tuberculosis | Rv2246 | 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) |
Mycobacterium ulcerans | MUL_1304 | 3-oxoacyl-(acyl carrier protein) synthase II |
Mycobacterium ulcerans | MUL_1303 | 3-oxoacyl-(acyl carrier protein) synthase II |
Neospora caninum | NCLIV_000530 | 3-oxoacyl-(Acyl-carrier-protein) synthase II, related |
Oryza sativa | 4335962 | Os04g0445700 |
Oryza sativa | 4343906 | Os07g0616200 |
Oryza sativa | 4328619 | Os02g0196900 |
Oryza sativa | 4340392 | Os06g0196600 |
Plasmodium berghei | PBANKA_1125100 | 3-oxoacyl-acyl-carrier protein synthase, putative |
Plasmodium falciparum | PF3D7_0626300 | 3-oxoacyl-acyl-carrier protein synthase I/II |
Plasmodium knowlesi | PKNH_1123500 | 3-oxoacyl-(acyl-carrier-protein) synthase, putative |
Plasmodium vivax | PVX_114420 | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative |
Plasmodium yoelii | PY04452 | 3-oxoacyl-acyl-carrier protein synthase I/II |
Saccharomyces cerevisiae | YER061C | fatty acid synthase CEM1 |
Schistosoma japonicum | Sjp_0091870 | ko:K09458 3-oxoacyl-[acyl-carrier-protein] synthase II [EC2.3.1.179], putative |
Schistosoma mansoni | Smp_009150.2 | 3-oxoacyl-[ACP] synthase |
Schmidtea mediterranea | mk4.052381.01 | 3-oxoacylAWw-acyl-carrier-protein+AF0- synthase, mitochondrial |
Schmidtea mediterranea | mk4.002539.02 | 3-oxoacylAWw-acyl-carrier-protein+AF0- synthase, mitochondrial |
Trypanosoma brucei gambiense | Tbg.972.2.2150 | beta-ketoacyl synthase family protein, putative |
Trypanosoma brucei | Tb927.2.3910 | beta-ketoacyl-ACP synthase |
Trypanosoma congolense | TcIL3000_2_510 | beta-ketoacyl synthase family protein, putative |
Trypanosoma congolense | TcIL3000_0_40860 | beta-ketoacyl synthase family protein, putative |
Trypanosoma cruzi | TcCLB.504157.20 | beta-ketoacyl synthase family protein, putative |
Trypanosoma cruzi | TcCLB.511109.120 | beta-ketoacyl synthase family protein, putative |
Toxoplasma gondii | TGME49_293590 | 3-oxoacyl-acyl-carrier protein synthase I/II, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0739 | 3-oxoacyl-ACP synthase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.3910 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.3910 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.3910 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.2.3910 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1095 | Escherichia coli | non-essential | goodall |
PBANKA_1125100 | Plasmodium berghei | Dispensable | plasmo |
TGME49_293590 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) | Compounds | References |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | Compounds | References |
Staphylococcus aureus | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | Compounds | References |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) | Compounds | References |