Detailed information for compound 1314447

Basic information

Technical information
  • TDR Targets ID: 1314447
  • Name: 2-(1,3-benzoxazol-2-ylsulfanyl)-N-(furan-2-yl methyl)acetamide
  • MW: 288.322 | Formula: C14H12N2O3S
  • H donors: 1 H acceptors: 2 LogP: 2.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CSc1nc2c(o1)cccc2)NCc1ccco1
  • InChi: 1S/C14H12N2O3S/c17-13(15-8-10-4-3-7-18-10)9-20-14-16-11-5-1-2-6-12(11)19-14/h1-7H,8-9H2,(H,15,17)
  • InChiKey: RLBPGIMQROMJEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1,3-benzoxazol-2-ylsulfanyl)-N-(2-furylmethyl)acetamide
  • 2-(1,3-benzoxazol-2-ylthio)-N-(2-furylmethyl)acetamide
  • 2-(1,3-benzoxazol-2-ylsulfanyl)-N-(furan-2-ylmethyl)ethanamide
  • ST068975
  • MLS000108810
  • SMR000104760
  • BIM-0037483.P001
  • ZINC00144832
  • 2-(Benzooxazol-2-ylsulfanyl)-N-furan-2-ylmethyl-acetamide
  • CBMicro_037567

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ABC transporter family protein 0.0091 0.286 0.2644
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0088 0.2742 0.2522
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1527 0.1271
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0091 0.286 0.5
Entamoeba histolytica multidrug resistance protein, putative 0.0103 0.3325 0.0803
Brugia malayi hypothetical protein 0.0091 0.286 0.2644
Echinococcus multilocularis ATP binding cassette sub family B 0.0091 0.286 0.2644
Entamoeba histolytica P-glycoprotein 6, putative 0.0091 0.286 0.0163
Giardia lamblia Multidrug resistance-associated protein 1 0.0103 0.3325 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0091 0.286 0.1333
Schistosoma mansoni multidrug resistance protein 0.0091 0.286 0.2738
Schistosoma mansoni multidrug resistance protein 0.0103 0.3325 0.3211
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0103 0.3325 0.1898
Loa Loa (eye worm) hypothetical protein 0.0091 0.286 0.2823
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0091 0.286 0.7026
Entamoeba histolytica ATP-binding cassette protein, putative 0.0103 0.3325 0.0803
Echinococcus granulosus multidrug resistance associated protein 7 0.0103 0.3325 0.3123
Brugia malayi MAP kinase sur-1 0.0062 0.1762 0.1512
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1762 0.1512
Schistosoma mansoni voltage-gated potassium channel 0.0097 0.3091 0.2973
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1762 0.1621
Trypanosoma brucei p-glycoprotein 0.0103 0.3325 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0103 0.3325 0.3123
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0581 0.042
Brugia malayi ABC transporter family protein 0.0091 0.286 0.2644
Loa Loa (eye worm) hypothetical protein 0.0103 0.3325 0.329
Echinococcus multilocularis 0.0091 0.286 0.2644
Loa Loa (eye worm) ABC transporter 0.0091 0.286 0.2823
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0103 0.3325 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0091 0.286 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1762 0.1512
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0089 0.2803 0.2586
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0088 0.2742 0.2522
Echinococcus multilocularis ATP binding cassette sub family B 0.0091 0.286 0.2644
Echinococcus multilocularis ATP binding cassette sub family B 0.0091 0.286 0.2644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1527 0.1271
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0088 0.2742 0.2618
Echinococcus multilocularis ATP binding cassette sub family B 0.0091 0.286 0.2644
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0091 0.286 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0089 0.2803 0.2586
Loa Loa (eye worm) hypothetical protein 0.0192 0.6636 0.6619
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1527 0.1271
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1762 0.1512
Echinococcus granulosus sodium channel protein 0.0091 0.2857 0.2641
Brugia malayi ABC transporter transmembrane region family protein 0.0091 0.286 0.2644
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1762 0.1719
Toxoplasma gondii hypothetical protein 0.0192 0.6636 0.5917
Echinococcus granulosus ATP binding cassette sub family B 0.0091 0.286 0.2644
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1762 0.1512
Echinococcus granulosus multidrug resistance protein 1 0.0195 0.6727 0.6628
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1527 0.1382
Schistosoma mansoni multidrug resistance protein 0.0103 0.3325 0.3211
Schistosoma mansoni voltage-gated potassium channel 0.0097 0.3091 0.2973
Giardia lamblia Hypothetical protein 0.0088 0.2742 0.627
Brugia malayi ABC transporter 0.0088 0.2742 0.2522
Loa Loa (eye worm) hypothetical protein 0.003 0.0581 0.0532
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0103 0.3325 0.329
Brugia malayi ABC transporter transmembrane region family protein 0.0088 0.2742 0.2522
Leishmania major p-glycoprotein e 0.0103 0.3325 0.1898
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0091 0.286 0.7026
Leishmania major pentamidine resistance protein 1 0.0103 0.3325 0.1898
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0091 0.286 0.1333
Giardia lamblia Multidrug resistance-associated protein 1 0.0103 0.3325 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0091 0.286 0.1333
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0078 0.2392 0.2161
Loa Loa (eye worm) hypothetical protein 0.0022 0.0294 0.0243
Leishmania major ABC-thiol transporter 0.0103 0.3325 0.1898
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1762 0.1512
Loa Loa (eye worm) ABC transporter 0.0091 0.286 0.2823
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0294 0.0243
Giardia lamblia ABC transporter, putative 0.0103 0.3325 1
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0091 0.286 0.1333
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0103 0.3325 0.1898
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0088 0.2742 0.627
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0078 0.2392 0.2161
Echinococcus multilocularis multidrug resistance associated protein 1 0.0103 0.3325 0.3123
Echinococcus granulosus ATP binding cassette sub family B 0.0088 0.2742 0.2522
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0091 0.286 0.286
Entamoeba histolytica P-glycoprotein 6, putative 0.0091 0.286 0.0163
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0294 0.0128
Echinococcus granulosus ATP binding cassette sub family B 0.0091 0.286 0.2644
Echinococcus granulosus voltage gated potassium channel 0.003 0.0581 0.0296
Entamoeba histolytica ABC transporter, putative 0.0103 0.3325 0.0803
Schistosoma mansoni multidrug resistance protein 0.0088 0.2742 0.2618
Brugia malayi P-glycoprotein-like protein 0.0091 0.286 0.2644
Entamoeba histolytica hypothetical protein 0.0103 0.3325 0.0803
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0103 0.3325 0.1898
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0091 0.286 0.1333
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0195 0.6727 0.6628
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0103 0.3325 1
Schistosoma mansoni smdr1 0.0091 0.286 0.2738
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0581 0.042
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1762 0.1512
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0279 0.9882 0.9878
Loa Loa (eye worm) ABC transporter 0.0091 0.286 0.2823
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0091 0.286 0.1333
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0088 0.2742 0.2522
Trypanosoma brucei multidrug resistance protein E 0.0103 0.3325 1
Toxoplasma gondii ABC transporter family protein 0.0091 0.286 0.1333
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0091 0.286 0.2644
Trypanosoma cruzi multidrug resistance protein E, putative 0.0103 0.3325 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.003 0.0581 0.0296
Echinococcus granulosus multidrug resistance associated protein 1 0.0103 0.3325 0.3123
Loa Loa (eye worm) hypothetical protein 0.0103 0.3325 0.329
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0091 0.286 0.5
Entamoeba histolytica ATP-binding cassette protein, putative 0.0103 0.3325 0.0803
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0192 0.6636 0.6619
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0294 0.0128
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0294 0.0128
Toxoplasma gondii ABC transporter, putative 0.0091 0.286 0.1333
Loa Loa (eye worm) hypothetical protein 0.0088 0.2742 0.2704
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.003 0.0581 0.0296
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1762 0.1512
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.2742 0.2522
Echinococcus multilocularis voltage gated potassium channel 0.003 0.0581 0.0296
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0091 0.286 0.5
Giardia lamblia MRP-like ABC transporter 0.0103 0.3325 1
Loa Loa (eye worm) hypothetical protein 0.01 0.3207 0.3171
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0091 0.286 0.7026
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0089 0.2803 0.2766
Loa Loa (eye worm) hypothetical protein 0.0192 0.6636 0.6619
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0091 0.286 0.1333
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0294 0.0128
Entamoeba histolytica ATP-binding cassette protein, putative 0.0103 0.3325 0.0803
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0091 0.286 0.286
Schistosoma mansoni multidrug resistance protein 0.0103 0.3325 0.3211
Brugia malayi ABC transporter 0.0091 0.286 0.2644
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0103 0.3325 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0103 0.3325 0.0803
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1527 0.1382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1527 0.1382
Echinococcus multilocularis multidrug resistance protein 1 0.0195 0.6727 0.6628
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0091 0.286 0.2644
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0103 0.3325 0.1898
Brugia malayi multidrug resistance related protein 1 0.0103 0.3325 0.3123
Brugia malayi ABC transporter transmembrane region family protein 0.0103 0.3325 0.3123
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0294 0.0128
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0091 0.2857 0.1329
Echinococcus granulosus multidrug resistance protein 1 0.0195 0.6727 0.6628
Loa Loa (eye worm) hypothetical protein 0.0192 0.6636 0.6619
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1527 0.1271
Giardia lamblia Multidrug resistance-associated protein 1 0.01 0.3207 0.9244
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0091 0.286 0.5
Loa Loa (eye worm) hypothetical protein 0.0279 0.9882 0.9881
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0294 0.0243
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0089 0.2803 0.2586
Schistosoma mansoni multidrug resistance protein 0.0103 0.3325 0.3211
Loa Loa (eye worm) hypothetical protein 0.0078 0.239 0.2351
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1527 0.1271
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0091 0.286 0.7026
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0091 0.286 0.5
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0091 0.286 0.2738
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0294 0.0128
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.003 0.0581 0.0296
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1527 0.1483
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0091 0.286 0.5
Echinococcus multilocularis sodium channel protein 0.0091 0.2857 0.2641
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0091 0.286 0.1333
Brugia malayi ABC transporter family protein 0.0091 0.286 0.2644
Echinococcus multilocularis ATP binding cassette sub family B 0.0279 0.9882 0.9878
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0091 0.286 0.1333
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0091 0.286 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1762 0.1512
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0103 0.3325 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0103 0.3325 0.1898
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0091 0.2857 0.2641

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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