Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4898 | 0.4898 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2168 | 0.2168 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.029 | 0.029 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3767 | 0.4979 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3767 | 0.3767 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.007 | 0.007 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0631 | 0.0631 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0631 | 0.0631 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.244 | 0.2673 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1955 | 0.183 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.029 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.294 | 0.294 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3767 | 0.4979 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2168 | 0.2168 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1955 | 0.1955 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1955 | 0.1955 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0411 | 0.0411 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4898 | 0.4898 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3767 | 0.3767 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.6164 | 0.6164 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2448 | 0.2448 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.272 | 0.272 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.029 | 0.029 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.6655 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0411 | 0.0411 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.5309 | 0.5309 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.