Detailed information for compound 1319196

Basic information

Technical information
  • TDR Targets ID: 1319196
  • Name: N-(2,5-dimethoxyphenyl)quinoline-3-carboxamid e
  • MW: 308.331 | Formula: C18H16N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)c1cnc2c(c1)cccc2)OC
  • InChi: 1S/C18H16N2O3/c1-22-14-7-8-17(23-2)16(10-14)20-18(21)13-9-12-5-3-4-6-15(12)19-11-13/h3-11H,1-2H3,(H,20,21)
  • InChiKey: AIVJSTUIZLCZBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,5-dimethoxyphenyl)-3-quinolinecarboxamide
  • MLS-0202010.0001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens alkaline phosphatase, liver/bone/kidney Starlite/ChEMBL No references
Homo sapiens glyceraldehyde-3-phosphate dehydrogenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania braziliensis glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126976 All targets in OG5_126976
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus alkaline phosphatase intestinal gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Babesia bovis glyceraldehyde-3-phosphate dehydrogenase protein Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum ko:K00134 glyceraldehyde 3-phosphate dehydrogenase [EC1.2.1.12], putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium berghei glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium knowlesi glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K01077 alkaline phosphatase [EC3.1.3.1], putative Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium parvum glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium hominis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), related Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative glyceraldehyde-3-phosphate dehydrogenase 293 aa 259 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0176 0.8833 1
Trichomonas vaginalis chromobox protein, putative 0.0082 0.3569 0.9997
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0798 0.0904
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0025 0.0394 0.1103
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.2145 0.2428
Brugia malayi Heterochromatin protein 1 0.0082 0.3569 0.4041
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0082 0.357 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.357 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.1989 0.2252
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1983 0.2245
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1983 0.5555
Echinococcus granulosus alkaline phosphatase 0.0196 1 1
Echinococcus multilocularis alkaline phosphatase 0.0196 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.1989 0.1989
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.357 1
Leishmania major pyruvate kinase 0.0033 0.0798 0.2236
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.357 0.357
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.357 0.357
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1981 0.5548
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.357 1
Schistosoma mansoni pyruvate kinase 0.0033 0.0798 0.0798
Echinococcus multilocularis muscleblind protein 0.0176 0.8833 0.8833
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0025 0.0394 0.1103
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.357 1
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.357 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0794 0.2225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.1989 0.1989
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0054 0.1981 0.5548
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.2145 0.2428
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0798 0.2236
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.357 1
Giardia lamblia Pyruvate kinase 0.0033 0.0798 0.2236
Trichomonas vaginalis chromobox protein, putative 0.0049 0.1743 0.4882
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.357 0.357
Echinococcus granulosus pyruvate kinase 0.0033 0.0798 0.0798
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.357 0.357
Echinococcus granulosus pyruvate kinase 0.0033 0.0798 0.0798
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.357 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.357 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.0046 0.1547 0.1752
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0277
Schistosoma mansoni pyruvate kinase 0.0033 0.0798 0.0798
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0025 0.0394 0.0446
Echinococcus multilocularis chromobox protein 1 0.0082 0.3569 0.3569
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0798 0.0904
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.357 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.1547 0.4334
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0196 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.1989 0.1989
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.357 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0798 0.0904
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1983 0.5555
Echinococcus multilocularis chromobox protein 1 0.0082 0.3569 0.3569
Schistosoma mansoni alkaline phosphatase 0.0196 1 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.0413 0.0413
Trichomonas vaginalis chromobox protein, putative 0.0049 0.1743 0.4882
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.357 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.357 1
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0082 0.357 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0798 0.0904
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.357 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.357 0.357
Leishmania major pyruvate kinase 0.0033 0.0798 0.2236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.1989 0.1989
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.357 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1983 0.1983
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0245 0.0277
Trichomonas vaginalis chromobox protein, putative 0.0082 0.3569 0.9997
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0798 0.2236
Schistosoma mansoni hypothetical protein 0.0102 0.47 0.47
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0798 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1983 0.1983
Brugia malayi chromobox protein homolog 3 0.0046 0.1547 0.1752
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.357 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0798 0.0904
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.357 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.1989 0.1989
Echinococcus granulosus muscleblind protein 0.0176 0.8833 0.8833
Echinococcus granulosus chromobox protein 1 0.0082 0.3569 0.3569
Loa Loa (eye worm) hypothetical protein 0.0054 0.1983 0.2245
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0025 0.0394 0.1103
Echinococcus granulosus chromobox protein 1 0.0082 0.3569 0.3569
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1981 0.5548
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0082 0.357 1
Plasmodium falciparum pyruvate kinase 0.0033 0.0798 0.2236
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1983 0.2245
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0798 0.2236
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1981 0.5548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.1989 0.1989
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0025 0.0394 0.1103
Schistosoma mansoni chromobox protein 0.0082 0.3569 0.3569
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.357 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.099 0.1121
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.3569 0.4041
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0196 1 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0798 0.0904
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1981 0.5548
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.357 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.8833 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0798 0.2236
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0798 0.2236
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.357 0.4042
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.1743 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.357 1
Schistosoma mansoni alkaline phosphatase 0.0196 1 1
Echinococcus multilocularis muscleblind protein 1 0.0176 0.8833 0.8833
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0028 0.0558 0.6985
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.1989 0.2252
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.357 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0028 0.0555 0.1555
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0082 0.357 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0798 0.2236
Schistosoma mansoni chromobox protein 0.0082 0.3569 0.3569
Onchocerca volvulus 0.0036 0.099 0.203
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0798 1
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0196 1 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0028 0.0555 0.0629
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0245 0.0685
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.357 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0798 0.2236
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0196 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.1547 0.4334
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.1547 0.7927
Echinococcus multilocularis pyruvate kinase 0.0033 0.0798 0.0798
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0196 1 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.357 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.1989 0.1989
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.357 0.357
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0025 0.0394 0.1103
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.357 0.357
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0798 0.2236
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0798 0.2236
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0082 0.357 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.357 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0794 0.2225
Brugia malayi Muscleblind-like protein 0.0176 0.8833 1
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0082 0.357 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.357 0.357

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 10 uM PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.