Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.0203 | 0.09 | 0.4081 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0106 | 0.118 |
Echinococcus multilocularis | UDP N acetylglucosamine dolichyl phosphate | 0.0203 | 0.09 | 0.4246 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0912 | 0.4302 |
Brugia malayi | CHE-14 protein | 0.0051 | 0.0055 | 0.0611 |
Toxoplasma gondii | glycosyl transferase, group 4 family protein | 0.0203 | 0.09 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0433 | 0.4814 |
Echinococcus granulosus | UDP N acetylglucosamine dolichyl phosphate | 0.0203 | 0.09 | 0.4246 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0045 | 0.0203 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0437 | 0.2206 | 1 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.1835 | 1 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.2046 | 1 |
Schistosoma mansoni | patched 1 | 0.0051 | 0.0055 | 0.0249 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.1835 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0189 | 0.0824 | 0.3735 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.0718 | 0.333 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.1835 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0045 | 0.0203 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0045 | 0.0203 |
Brugia malayi | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.0203 | 0.09 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.0393 | 0.1699 |
Plasmodium vivax | N-acetylglucosamine-1-phosphate transferase, putative | 0.0203 | 0.09 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.0433 | 0.1901 |
Trypanosoma cruzi | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.0203 | 0.09 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0121 | 0.0444 | 0.2011 |
Mycobacterium leprae | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.1835 | 1 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0058 | 0.0095 | 0.0202 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0189 | 0.0824 | 0.3735 |
Schistosoma mansoni | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.0203 | 0.09 | 0.4081 |
Onchocerca volvulus | 0.0177 | 0.0755 | 0.818 | |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.1835 | 1 | 0.5 |
Echinococcus granulosus | expressed conserved protein | 0.0112 | 0.0393 | 0.1699 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0119 | 0.1322 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.0718 | 0.333 |
Trichomonas vaginalis | glucosaminephosphotransferase, putative | 0.0203 | 0.09 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.0912 | 0.4302 |
Plasmodium falciparum | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.0203 | 0.09 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0104 | 0.0469 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0912 | 0.4131 |
Trypanosoma brucei | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.0203 | 0.09 | 0.5 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.0433 | 0.4814 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0055 | 0.0611 |
Giardia lamblia | UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase | 0.0203 | 0.09 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.0433 | 0.1901 |
Onchocerca volvulus | 0.0203 | 0.09 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0104 | 0.115 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0824 | 0.9152 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0912 | 0.4131 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0824 | 0.9152 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0051 | 0.0055 | 0.0611 |
Onchocerca volvulus | 0.0189 | 0.0824 | 0.9042 | |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0045 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0106 | 0.118 |
Trypanosoma cruzi | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.0203 | 0.09 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.2046 | 1 |
Brugia malayi | Trypsin family protein | 0.0189 | 0.0824 | 0.9152 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.09 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0106 | 0.118 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0106 | 0.118 |
Entamoeba histolytica | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.0203 | 0.09 | 1 |
Leishmania major | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative | 0.0203 | 0.09 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (ADMET) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (ADMET) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.