Detailed information for compound 1328047

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 255.335 | Formula: C15H13NOS
  • H donors: 0 H acceptors: 1 LogP: 3.74 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)n1sc2c(c1=O)cccc2)C
  • InChi: 1S/C15H13NOS/c1-10-7-8-11(2)13(9-10)16-15(17)12-5-3-4-6-14(12)18-16/h3-9H,1-2H3
  • InChiKey: KZWDYISQJWCAHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatase, orphan 1 Starlite/ChEMBL References
Homo sapiens mannose phosphate isomerase Starlite/ChEMBL References
Homo sapiens phosphomannomutase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans phosphomannomutase that can functionally substitute for S. cerevisiae SEC53 (YFL045C) Get druggable targets OG5_127648 All targets in OG5_127648
Leishmania major phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Trypanosoma brucei phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium knowlesi phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Trypanosoma cruzi phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Trypanosoma congolense phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Loa Loa (eye worm) mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Toxoplasma gondii phosphomannose isomerase type I protein Get druggable targets OG5_127555 All targets in OG5_127555
Loa Loa (eye worm) phosphomannomutase 2 Get druggable targets OG5_127648 All targets in OG5_127648
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127648 All targets in OG5_127648
Entamoeba histolytica phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Schistosoma mansoni phosphomannomutase Get druggable targets OG5_127648 All targets in OG5_127648
Plasmodium yoelii Phosphomannose isomerase type I, putative Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium knowlesi mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus multilocularis phosphomannomutase Get druggable targets OG5_127648 All targets in OG5_127648
Brugia malayi mannose-6-phosphate isomerase, class I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Neospora caninum phosphomannomutase 2, putative Get druggable targets OG5_127648 All targets in OG5_127648
Leishmania major phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium berghei mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma brucei phosphomannomutase Get druggable targets OG5_127648 All targets in OG5_127648
Brugia malayi phosphomannomutase 2 Get druggable targets OG5_127648 All targets in OG5_127648
Loa Loa (eye worm) mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania mexicana phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Babesia bovis phosphomannose isomerase type I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Cryptosporidium parvum mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium vivax mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium falciparum phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Cryptosporidium parvum phosphomannomutase Get druggable targets OG5_127648 All targets in OG5_127648
Leishmania mexicana phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho Get druggable targets OG5_127555 All targets in OG5_127555
Neospora caninum hypothetical protein Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma congolense phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma mansoni mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Onchocerca volvulus Putative phosphomannomutase Get druggable targets OG5_127648 All targets in OG5_127648
Theileria parva phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Leishmania donovani phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Babesia bovis phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Theileria parva mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Candida albicans mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma brucei gambiense phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma cruzi phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Toxoplasma gondii phosphomannomutase Get druggable targets OG5_127648 All targets in OG5_127648
Schistosoma japonicum ko:K01840 phosphomannomutase [EC5.4.2.8], putative Get druggable targets OG5_127648 All targets in OG5_127648
Echinococcus granulosus phosphomannomutase Get druggable targets OG5_127648 All targets in OG5_127648
Leishmania braziliensis phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO Get druggable targets OG5_127555 All targets in OG5_127555
Trichomonas vaginalis mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania infantum phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Leishmania braziliensis phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Trichomonas vaginalis phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Echinococcus granulosus mannose 6 phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium berghei phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Candida albicans phosphomannomutase that can functionally substitute for S. cerevisiae SEC53 (YFL045C) Get druggable targets OG5_127648 All targets in OG5_127648
Trypanosoma cruzi phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma brucei gambiense phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Schistosoma japonicum IPR005002,Eukaryotic phosphomannomutase,domain-containing Get druggable targets OG5_127648 All targets in OG5_127648
Leishmania infantum phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania donovani phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Brugia malayi mannose-6-phosphate isomerase, class I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127555 All targets in OG5_127555
Entamoeba histolytica phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium vivax phosphomannomutase, putative Get druggable targets OG5_127648 All targets in OG5_127648
Echinococcus multilocularis mannose 6 phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium yoelii Eukaryotic phosphomannomutase Get druggable targets OG5_127648 All targets in OG5_127648
Plasmodium falciparum mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Candida albicans mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma japonicum ko:K01809 mannose-6-phosphate isomerase [EC5.3.1.8], putative Get druggable targets OG5_127555 All targets in OG5_127555
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative phosphatase, orphan 1 292 aa 281 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphomannomutase 0.0052 0.0178 0.0338
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0078 0.0361 0.5665
Schistosoma mansoni Smad4 0.0044 0.0126 0.024
Trypanosoma cruzi phosphomannose isomerase, putative 0.0117 0.0636 1
Schistosoma mansoni hypothetical protein 0.0307 0.1956 0.3714
Brugia malayi MH2 domain containing protein 0.0099 0.051 0.051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0969 0.6579 0.6579
Echinococcus granulosus GPCR family 2 0.0307 0.1956 0.3714
Echinococcus multilocularis Smad4 0.0099 0.051 0.0968
Echinococcus multilocularis GPCR, family 2 0.0307 0.1956 0.3714
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0969 0.6579 0.6579
Schistosoma mansoni tar DNA-binding protein 0.0781 0.5267 1
Trypanosoma cruzi phosphomannose isomerase, putative 0.0117 0.0636 1
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0066 0.0275 0.4307
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0117 0.0636 0.0636
Schistosoma mansoni tar DNA-binding protein 0.0781 0.5267 1
Loa Loa (eye worm) RNA binding protein 0.0781 0.5267 0.5267
Loa Loa (eye worm) hypothetical protein 0.0055 0.02 0.02
Schistosoma mansoni smad1 5 8 and 0.0099 0.051 0.0968
Loa Loa (eye worm) nuclear factor I 0.0055 0.02 0.02
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0078 0.0361 0.0686
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0044 0.0126 0.0355
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0307 0.1956 0.1956
Brugia malayi hypothetical protein 0.0038 0.0079 0.0079
Echinococcus granulosus TGF beta signal transducer SmadC 0.0099 0.051 0.0968
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0361 0.5665
Echinococcus granulosus Smad4 0.0099 0.051 0.0968
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0099 0.051 0.0968
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0117 0.0636 0.0636
Toxoplasma gondii isocitrate dehydrogenase 0.0078 0.0361 0.5679
Schistosoma mansoni mannose-6-phosphate isomerase 0.0117 0.0636 0.1207
Trypanosoma brucei phosphomannose isomerase 0.0117 0.0636 1
Loa Loa (eye worm) TAR-binding protein 0.0781 0.5267 0.5267
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0117 0.0636 0.1207
Echinococcus multilocularis phosphomannomutase 0.0052 0.0178 0.0338
Onchocerca volvulus Putative phosphomannomutase 0.0052 0.0178 0.05
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0066 0.0275 0.4307
Entamoeba histolytica phosphomannomutase, putative 0.0052 0.0178 0.1777
Echinococcus granulosus tar DNA binding protein 0.0781 0.5267 1
Schistosoma mansoni tar DNA-binding protein 0.0781 0.5267 1
Loa Loa (eye worm) hypothetical protein 0.0535 0.3553 0.3553
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0535 0.3553 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0969 0.6579 0.6579
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0126 0.0126
Echinococcus granulosus mothers against decapentaplegic 6 0.0044 0.0126 0.024
Echinococcus granulosus mothers against decapentaplegic 5 0.0099 0.051 0.0968
Entamoeba histolytica phosphomannose isomerase, putative 0.0117 0.0636 1
Brugia malayi MH2 domain containing protein 0.0099 0.051 0.051
Schistosoma mansoni smad1 5 8 and 0.0099 0.051 0.0968
Schistosoma mansoni tar DNA-binding protein 0.0781 0.5267 1
Echinococcus multilocularis tar DNA binding protein 0.0781 0.5267 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0078 0.0361 0.0686
Loa Loa (eye worm) hypothetical protein 0.0662 0.4439 0.4439
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0126 0.0126
Brugia malayi hypothetical protein 0.0027 0.0002 0.0002
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0361 0.5665
Brugia malayi N-terminal motif family protein 0.0535 0.3553 0.3553
Echinococcus multilocularis isocitrate dehydrogenase 0.0078 0.0361 0.0686
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0054 0.0191 0.2022
Echinococcus multilocularis smad 0.0099 0.051 0.0968
Echinococcus granulosus mothers against decapentaplegic 2 0.0044 0.0126 0.024
Echinococcus granulosus mannose 6 phosphate isomerase 0.0117 0.0636 0.1207
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0361 0.0686
Echinococcus granulosus smad 0.0099 0.051 0.0968
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0066 0.0275 0.4307
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0117 0.0636 1
Loa Loa (eye worm) hypothetical protein 0.0969 0.6579 0.6579
Loa Loa (eye worm) MH2 domain-containing protein 0.1459 1 1
Schistosoma mansoni phosphomannomutase 0.0052 0.0178 0.0338
Schistosoma mansoni hypothetical protein 0.0662 0.4439 0.8428
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0002 0.0032
Schistosoma mansoni hypothetical protein 0.0307 0.1956 0.3714
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0117 0.0636 0.5
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0078 0.0361 0.5665
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0099 0.051 0.0968
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0079 0.015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0307 0.1956 0.3714
Leishmania major phosphomannomutase, putative 0.0052 0.0178 0.2774
Brugia malayi RNA recognition motif domain containing protein 0.0781 0.5267 0.5267
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0078 0.0361 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0307 0.1956 0.3714
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0079 0.015
Brugia malayi isocitrate dehydrogenase 0.0078 0.0361 0.0361
Trypanosoma cruzi phosphomannomutase, putative 0.0052 0.0178 0.2774
Plasmodium falciparum phosphomannomutase, putative 0.0052 0.0178 0.2774
Toxoplasma gondii phosphomannomutase 0.0052 0.0178 0.2797
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0078 0.0361 0.5665
Brugia malayi RNA binding protein 0.0781 0.5267 0.5267
Loa Loa (eye worm) transcription factor SMAD2 0.1459 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0307 0.1956 0.1956
Brugia malayi MH1 domain containing protein 0.0099 0.051 0.051
Brugia malayi Latrophilin receptor protein 2 0.0307 0.1956 0.1956
Brugia malayi phosphomannomutase 2 0.0052 0.0178 0.0178
Brugia malayi MH1 domain containing protein 0.0055 0.02 0.02
Brugia malayi mothers against decapentaplegic homolog 3 0.0044 0.0126 0.0126
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0117 0.0636 1
Schistosoma mansoni hypothetical protein 0.0038 0.0079 0.015
Loa Loa (eye worm) isocitrate dehydrogenase 0.0078 0.0361 0.0361
Echinococcus multilocularis mothers against decapentaplegic 6 0.0044 0.0126 0.024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0307 0.1956 0.3714
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0078 0.0361 0.5665
Echinococcus multilocularis mothers against decapentaplegic 5 0.0099 0.051 0.0968
Brugia malayi TAR-binding protein 0.0781 0.5267 0.5267
Toxoplasma gondii isocitrate dehydrogenase 0.0078 0.0361 0.5679
Schistosoma mansoni hypothetical protein 0.0307 0.1956 0.3714
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0781 0.5267 0.5267
Schistosoma mansoni Smad4 0.0044 0.0126 0.024
Leishmania major phosphomannose isomerase 0.0117 0.0636 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0099 0.051 0.051
Brugia malayi Isocitrate dehydrogenase 0.0078 0.0361 0.0361
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0117 0.0636 1
Brugia malayi Smad1 0.0099 0.051 0.051
Echinococcus multilocularis mothers against decapentaplegic 2 0.0044 0.0126 0.024
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0361 0.5665
Schistosoma mansoni smad 0.0099 0.051 0.0968
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0307 0.1956 0.3714
Brugia malayi MH1 domain containing protein 0.0055 0.02 0.02
Brugia malayi latrophilin 2 splice variant baaae 0.0662 0.4439 0.4439
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0079 0.015
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0064 0.0261 0.5
Schistosoma mansoni tar DNA-binding protein 0.0781 0.5267 1
Loa Loa (eye worm) Smad1 0.0099 0.051 0.051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0361 0.0686
Trypanosoma brucei phosphomannomutase 0.0052 0.0178 0.2774
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0117 0.0636 0.0636
Leishmania major hypothetical protein, conserved 0.0066 0.0275 0.4307
Schistosoma mansoni smad1 5 8 and 0.0099 0.051 0.0968
Schistosoma mansoni smad 0.0044 0.0126 0.024
Brugia malayi MH1 domain containing protein 0.0099 0.051 0.051
Plasmodium vivax phosphomannomutase, putative 0.0052 0.0178 0.2774
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0361 0.0686
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0078 0.0361 0.0686
Loa Loa (eye worm) MH1 domain-containing protein 0.0099 0.051 0.051
Toxoplasma gondii phosphomannose isomerase type I protein 0.0117 0.0636 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0307 0.1956 0.1956
Loa Loa (eye worm) phosphomannomutase 2 0.0052 0.0178 0.0178
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0307 0.1956 0.3714
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0117 0.0636 0.0636
Brugia malayi MH2 domain containing protein 0.0044 0.0126 0.0126
Schistosoma mansoni Smad4 0.0099 0.051 0.0968

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.67 uM PUBCHEM_BIOASSAY: Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1209, AID1220, AID1545, AID1553, AID1574, AID1620] ChEMBL. No reference
IC50 (binding) = 4 uM Inhibition of PHOSPHO1 phosphoethanolamine activity (unknown origin) assessed as amount of inorganic phosphate release after 30 mins ChEMBL. 25124115
IC50 (binding) = 5.04 uM PUBCHEM_BIOASSAY: SAR assay for compounds that inhibit PHOSPHO1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1545, AID1565, AID1574] ChEMBL. No reference
IC50 (binding) = 5.51 uM PUBCHEM_BIOASSAY: Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1209, AID1220, AID1545, AID1553, AID1620] ChEMBL. No reference
IC50 (binding) = 6.6 uM Inhibition of human purified phosphomannose isomerase ChEMBL. 21539312
IC50 (binding) = 6.6 uM Inhibition of phosphomannose isomerase (unknown origin) ChEMBL. 25124115
IC50 (binding) = 17.9 uM PUBCHEM_BIOASSAY: Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1545, AID1574] ChEMBL. No reference
IC50 (binding) = 17.9 uM Inhibition of human purified PMM2 ChEMBL. 21539312
IC50 (binding) > 20 uM Inhibition of PMM2 (unknown origin) ChEMBL. 25124115
IC50 (binding) > 100 uM PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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