Detailed information for compound 1330529

Basic information

Technical information
  • TDR Targets ID: 1330529
  • Name: 7-butyl-1,3-dimethyl-5-(2-morpholin-4-yl-2-ox oethyl)sulfanylpyrimido[5,6-e]pyrimidine-2,4- dione
  • MW: 407.487 | Formula: C18H25N5O4S
  • H donors: 0 H acceptors: 5 LogP: 1.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1nc(SCC(=O)N2CCOCC2)c2c(n1)n(C)c(=O)n(c2=O)C
  • InChi: 1S/C18H25N5O4S/c1-4-5-6-12-19-15-14(17(25)22(3)18(26)21(15)2)16(20-12)28-11-13(24)23-7-9-27-10-8-23/h4-11H2,1-3H3
  • InChiKey: JQCIWOOEWBBPTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-butyl-1,3-dimethyl-5-(2-morpholino-2-oxo-ethyl)sulfanyl-pyrimido[5,6-e]pyrimidine-2,4-dione
  • 7-butyl-1,3-dimethyl-5-[(2-morpholino-2-oxoethyl)thio]pyrimido[5,6-e]pyrimidine-2,4-dione
  • 7-butyl-5-[(2-keto-2-morpholino-ethyl)thio]-1,3-dimethyl-pyrimido[5,6-e]pyrimidine-2,4-quinone
  • 7-butyl-1,3-dimethyl-5-(2-morpholin-4-yl-2-oxo-ethyl)sulfanyl-pyrimido[5,6-e]pyrimidine-2,4-dione
  • ZINC05056517

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0124 0.0124
Schistosoma mansoni hypothetical protein 0.0172 0.5293 0.5293
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0124 0.0124
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0124 0.0124
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.025 0.2199
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0124 0.0188
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0085 0.0752
Schistosoma mansoni chromobox protein 0.0071 0.1898 0.1898
Loa Loa (eye worm) hypothetical protein 0.0031 0.057 0.057
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0292 0.0292
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0168 0.0465
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0085 0.0752
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0958 0.1163
Brugia malayi glutathione reductase 0.0048 0.1137 0.172
Loa Loa (eye worm) hypothetical protein 0.0018 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0124 0.0124
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.3197 0.8865
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0124 0.0124
Echinococcus multilocularis snurportin 1 0.0313 1 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0085 0.0237
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.025 0.1565
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0124 0.0188
Loa Loa (eye worm) hypothetical protein 0.0018 0.0124 0.0124
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0292 0.257
Onchocerca volvulus 0.0241 0.7586 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0958 0.1163
Plasmodium falciparum importin beta, putative 0.0029 0.0509 0.4029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0544 0.0544
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0124 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0124 0.0188
Loa Loa (eye worm) glutathione reductase 0.0048 0.1137 0.1137
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0168 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0124 0.0124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0544 0.0544
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.025 0.1565
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0124 0.0188
Plasmodium vivax importin-beta 2, putative 0.0029 0.0509 0.4029
Schistosoma mansoni ap endonuclease 0.0019 0.0168 0.0168
Leishmania major importin beta-1 subunit, putative 0.0024 0.0323 0.2846
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.3197 0.8865
Mycobacterium tuberculosis Probable reductase 0.011 0.3197 0.8865
Brugia malayi Importin beta-1 subunit 0.0029 0.0509 0.077
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0168 0.1476
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0124 0.0124
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.3607 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0124 0.0124
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0124 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0124 0.0124
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0085 0.2925
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0544 0.0544
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.024 0.7567 0.7567
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0124 0.0124
Plasmodium vivax SET domain protein, putative 0.003 0.0544 0.4358
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0168 0.011
Brugia malayi Cytochrome P450 family protein 0.0033 0.0636 0.0963
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.1137 0.1137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0168 0.1476
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0085 0.0752
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0124 0.0124
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.3197 0.8865
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0124 0.0124
Schistosoma mansoni hypothetical protein 0.0313 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.3197 0.8865
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0168 0.0168
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.3197 0.8865
Echinococcus granulosus geminin 0.0172 0.5293 0.5293
Leishmania major cytochrome p450-like protein 0.0023 0.0292 0.257
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0124 0.0124
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.025 0.2199
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.025 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.3607 1
Toxoplasma gondii thioredoxin reductase 0.0048 0.1137 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.1137 0.1137
Entamoeba histolytica hypothetical protein 0.0024 0.0323 1
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.1137 1
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0124 0.0124
Brugia malayi chromobox protein homolog 3 0.004 0.0857 0.1296
Brugia malayi Thioredoxin reductase 0.0048 0.1137 0.172
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0292 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0085 0.0752
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0544 0.4782
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0124 0.0188
Onchocerca volvulus 0.0031 0.057 0.0597
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0124 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0085 0.0752
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0124 0.0124
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0168 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0124 0.0124
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.1898 0.1898
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0124 0.0188
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0168 0.011
Echinococcus granulosus importin subunit beta 1 0.0029 0.0509 0.0509
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.025 0.025
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0085 0.0752
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0857 0.0981
Schistosoma mansoni ran 0.0022 0.025 0.025
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.6608 0.6608
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0124 0.0124
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0124 0.0124
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.3607 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0124 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0124 0.0188
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0958 0.1116
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0124 0.0188
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0292 0.257
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0124 0.0188
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.1137 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.3607 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.1137 0.3151
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0249 0.7882 0.7882
Brugia malayi RNA, U transporter 1 0.0083 0.2318 0.3507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0544 0.0544
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0124 0.0124
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0085 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0857 0.1028
Schistosoma mansoni retinoic acid receptor RXR 0.0249 0.7882 0.7882
Echinococcus multilocularis chromobox protein 1 0.0071 0.1898 0.1898
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0124 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0085 0.0752
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0085 0.0752
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0124 0.0124
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0168 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.1137 0.1137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0085 0.0752
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0323 0.0317
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0124 0.0124
Trichomonas vaginalis ran, putative 0.0022 0.025 0.0219
Brugia malayi Pre-SET motif family protein 0.003 0.0544 0.0823
Plasmodium falciparum thioredoxin reductase 0.0048 0.1137 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0168 0.1476
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0085 0.0752
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0124 0.0124
Brugia malayi nuclear hormone receptor 0.0018 0.0124 0.0188
Trichomonas vaginalis chromobox protein, putative 0.0071 0.1898 0.2417
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0124 0.0188
Schistosoma mansoni ran 0.0022 0.025 0.025
Schistosoma mansoni chromobox protein 0.0071 0.1898 0.1898
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0085 0.0752
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0168 0.1476
Loa Loa (eye worm) hypothetical protein 0.0018 0.0124 0.0124
Schistosoma mansoni importin beta-1 0.0029 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0029 0.0509 0.0509
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0292 0.0292
Onchocerca volvulus 0.0042 0.0931 0.1082
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0085 0.0129
Entamoeba histolytica Ran family GTPase 0.0022 0.025 0.5279
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0168 0.0784
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0636 0.0636
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0509 0.4478
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0931 0.0931
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.025 0.2199
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0292 0.257
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0124 0.0188
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0124 0.0124
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0509 0.4478
Schistosoma mansoni hypothetical protein 0.0172 0.5293 0.5293
Loa Loa (eye worm) hypothetical protein 0.003 0.0544 0.0544
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.3197 0.8865
Brugia malayi Cytochrome P450 family protein 0.0023 0.0292 0.0442
Schistosoma mansoni ap endonuclease 0.0019 0.0168 0.0168
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0124 0.0124
Echinococcus granulosus chromobox protein 1 0.0071 0.1898 0.1898
Brugia malayi Cytochrome P450 family protein 0.0023 0.0292 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0857 0.1028
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0124 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0124 0.0124
Brugia malayi ecdysteroid receptor 0.0018 0.0124 0.0188
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0323 0.0317
Loa Loa (eye worm) hypothetical protein 0.004 0.0857 0.0857
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0168 0.1476
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0085 0.5
Plasmodium vivax glutathione reductase, putative 0.0048 0.1137 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0085 0.0752
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0323 0.2846
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0124 0.0124
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0544 0.0544
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0124 0.0124
Trypanosoma brucei trypanothione reductase 0.0048 0.1137 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0124 0.0188
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0168 0.5745
Loa Loa (eye worm) hypothetical protein 0.0018 0.0124 0.0124
Brugia malayi Pre-SET motif family protein 0.0211 0.6608 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0085 0.0085
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0085 0.0752
Loa Loa (eye worm) hypothetical protein 0.0018 0.0124 0.0124
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0085 0.0752
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0323 0.0317
Brugia malayi Heterochromatin protein 1 0.0071 0.1898 0.2872
Trichomonas vaginalis set domain proteins, putative 0.0241 0.7586 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0509 0.0509
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0124 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0124 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0085 0.0752
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0124 0.0124
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0085 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0124 0.0124
Brugia malayi steroid hormone receptor 0.0018 0.0124 0.0188
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0085 0.2925
Schistosoma mansoni coup transcription factor 0.0018 0.0124 0.0124
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0085 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0124 0.0188
Echinococcus granulosus chromobox protein 1 0.0071 0.1898 0.1898
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0509 0.4478
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0168 0.5006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0124 0.0124
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0506 0.0506
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0168 0.0168
Leishmania major trypanothione reductase 0.0048 0.1137 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0124 0.0124
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0085 0.0752
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0168 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.025 0.0378
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.025 0.2199
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0085 0.2925
Brugia malayi nuclear receptor NHR-88 0.0018 0.0124 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0124 0.0124
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0085 0.0752
Plasmodium falciparum glutathione reductase 0.0048 0.1137 1
Trichomonas vaginalis chromobox protein, putative 0.0071 0.1898 0.2417
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0544 0.0544
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 1 1
Echinococcus multilocularis geminin 0.0172 0.5293 0.5293
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0469 0.0511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0124 0.0124
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.025 0.025
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0292 0.0292
Leishmania major GTP-binding protein, putative 0.0022 0.025 0.2199
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0085 0.0752
Echinococcus multilocularis chromobox protein 1 0.0071 0.1898 0.1898
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0168 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0469 0.0511

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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