Detailed information for compound 1338159

Basic information

Technical information
  • TDR Targets ID: 1338159
  • Name: methyl 2-[(2-imidazol-1-ylacetyl)amino]benzoa te
  • MW: 259.261 | Formula: C13H13N3O3
  • H donors: 1 H acceptors: 3 LogP: 1.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccccc1NC(=O)Cn1cncc1
  • InChi: 1S/C13H13N3O3/c1-19-13(18)10-4-2-3-5-11(10)15-12(17)8-16-7-6-14-9-16/h2-7,9H,8H2,1H3,(H,15,17)
  • InChiKey: UJVHCIXNLMVXFA-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[[2-(1-imidazolyl)-1-oxoethyl]amino]benzoic acid methyl ester
  • 2-[(2-imidazol-1-ylacetyl)amino]benzoic acid methyl ester
  • methyl 2-(2-imidazol-1-ylethanoylamino)benzoate
  • SMR000019319
  • ChemDiv2_000540
  • EU-0051347
  • A1177/0054606
  • ZINC00037427
  • 2-(2-Imidazol-1-yl-acetylamino)-benzoic acid methyl ester
  • BAS 01521829
  • Oprea1_764505
  • MLS000084973

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens aryl hydrocarbon receptor Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis aryl hydrocarbon receptor Get druggable targets OG5_133500 All targets in OG5_133500
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133500 All targets in OG5_133500
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133500 All targets in OG5_133500
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09093 aryl hydrocarbon receptor, putative Get druggable targets OG5_133500 All targets in OG5_133500
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_133500 All targets in OG5_133500
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aryl hydrocarbon receptor Get druggable targets OG5_133500 All targets in OG5_133500
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133500 All targets in OG5_133500
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus aryl hydrocarbon receptor Get druggable targets OG5_133500 All targets in OG5_133500
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR001189,Manganese and iron superoxide dismutase,domain-containing Get druggable targets OG5_133500 All targets in OG5_133500
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi aryl hydrocarbon receptor AHR-1 Get druggable targets OG5_133500 All targets in OG5_133500
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0694 0.1923
Brugia malayi Cathepsin L-like precursor 0.002 0.0047 0.0132
Echinococcus multilocularis cysteine protease 0.002 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.01 0.1524 0.4214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.003 0.0236 0.0664
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.021 0.3552 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.021 0.3552 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0694 0.1923
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Loa Loa (eye worm) hypothetical protein 0.0038 0.038 0.1069
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0047 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0047 0.0047
Brugia malayi bHLH-PAS transcription factor 0.0054 0.0678 0.1909
Brugia malayi Cathepsin L-like precursor 0.002 0.0047 0.0132
Schistosoma mansoni hypothetical protein 0.019 0.3187 0.8825
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0104 0.0293
Entamoeba histolytica protein kinase, putative 0.01 0.1524 0.4214
Leishmania major cathepsin L-like protease 0.002 0.0047 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0073
Echinococcus granulosus dna polymerase eta 0.0023 0.0104 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0869 0.5627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Leishmania major cathepsin L-like protease 0.002 0.0047 0.014
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.01 0.1524 0.429
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0047 0.006
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0104 0.0104
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.021 0.3552 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0047 0.0132
Leishmania major protein kinase, putative 0.002 0.0035 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0047 0.006
Onchocerca volvulus 0.0055 0.069 0.1834
Leishmania major hypothetical protein, conserved 0.003 0.0236 0.1402
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0047 0.013
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0065 0.0869 0.239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Schistosoma mansoni single-minded 0.0073 0.1031 0.2855
Schistosoma mansoni hypothetical protein 0.019 0.3187 0.8825
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0047 0.0047
Brugia malayi Cathepsin L-like precursor 0.002 0.0047 0.0132
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0047 0.0047
Loa Loa (eye worm) cysteine protease 0.002 0.0047 0.0132
Loa Loa (eye worm) hypothetical protein 0.014 0.2253 0.6344
Brugia malayi Protein kinase domain containing protein 0.01 0.1524 0.429
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0869 0.5627
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0065 0.0869 0.5386
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0793 0.512
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0145 0.2356 1
Echinococcus granulosus aryl hydrocarbon receptor 0.0159 0.2606 0.2606
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0104 0.0521
Mycobacterium leprae Possible regulatory protein 0.0019 0.0026 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0104 0.0521
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0065 0.0869 0.239
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.002 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0104 0.0221
Onchocerca volvulus 0.0158 0.2594 0.7268
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0047 0.0047
Leishmania major cathepsin L-like protease 0.0077 0.1098 0.7155
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0236 1
Echinococcus multilocularis geminin 0.019 0.3187 0.3187
Loa Loa (eye worm) fibroinase 0.002 0.0047 0.0132
Loa Loa (eye worm) hypothetical protein 0.0139 0.2241 0.6311
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.01 0.1524 1
Echinococcus granulosus single minded 2 0.0054 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.01 0.1514 0.4263
Echinococcus granulosus cathepsin l1 0.002 0.0047 0.0047
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.021 0.3552 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0047 0.006
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.021 0.3552 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Schistosoma mansoni aryl hydrocarbon receptor 0.0213 0.3611 1
Leishmania major protein kinase, putative 0.002 0.0035 0.0064
Echinococcus multilocularis neuropeptide receptor A26 0.0558 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0047 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0104 0.0521
Onchocerca volvulus 0.021 0.3552 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Echinococcus multilocularis cysteine protease 0.002 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.0056 0.0707 0.199
Loa Loa (eye worm) ctsf protein 0.002 0.0047 0.0132
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0104 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1098 0.7155
Brugia malayi Cathepsin L-like precursor 0.002 0.0047 0.0132
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0047 0.013
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0104 0.0163
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.01 0.1524 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.0158 0.2594 0.7304
Leishmania major DNA polymerase kappa, putative 0.0023 0.0104 0.0521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0047 0.0132
Entamoeba histolytica hypothetical protein 0.01 0.1524 0.4214
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.1524 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.021 0.3552 1
Brugia malayi hypothetical protein 0.003 0.0236 0.0664
Leishmania major cathepsin L-like protease 0.0077 0.1098 0.7155
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0974 0.633
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0104 0.0288
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.002 0.0035 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0104 0.0521
Schistosoma mansoni hypothetical protein 0.0038 0.038 0.1051
Brugia malayi Cathepsin L-like precursor 0.002 0.0047 0.0132
Echinococcus multilocularis transfer RNA-Lys 0.0054 0.0678 0.0678
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.002 0.0038 0.0038
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.0035 0.0064
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.002 0.0035 0.0064
Brugia malayi PAS domain containing protein 0.0073 0.1031 0.2903
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0139 0.2241 0.6311
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0236 0.1402
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0236 0.1402
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0019 0.0026 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0047 0.014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.0293
Mycobacterium ulcerans putative regulatory protein 0.0054 0.0678 0.1665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0104 0.0288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0047 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0694 0.0694
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.021 0.3552 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1514 0.4263
Leishmania major cathepsin L-like protease 0.002 0.0047 0.014
Leishmania major cathepsin L-like protease 0.002 0.0047 0.014
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0236 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.021 0.3552 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1098 0.7155
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0047 0.0132
Echinococcus granulosus dual specificity 0.01 0.1524 0.1524
Echinococcus granulosus neuropeptide receptor A26 0.0558 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1524 0.4219
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0236 0.0929
Leishmania major cathepsin L-like protease 0.0077 0.1098 0.7155
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0132
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.021 0.3552 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1098 0.7155
Leishmania major DNA polymerase eta, putative 0.0023 0.0104 0.0521
Echinococcus granulosus geminin 0.019 0.3187 0.3187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0047 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.0035 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0104 0.0521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0047 0.006
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0104 0.0221
Leishmania major cysteine peptidase A (CPA) 0.002 0.0047 0.014
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1098 0.7155
Leishmania major cathepsin L-like protease 0.002 0.0047 0.014
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0047 0.0047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0694 0.1955
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0047 0.0047
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0236 1
Schistosoma mansoni DNA polymerase eta 0.0023 0.0104 0.0288
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0104 0.0521
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.002 0.0038 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0694 0.1923
Echinococcus multilocularis neuropeptide s receptor 0.0558 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0104 0.0293
Echinococcus multilocularis aryl hydrocarbon receptor 0.0159 0.2606 0.2606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Echinococcus multilocularis dna polymerase eta 0.0023 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0047 0.006
Entamoeba histolytica protein kinase domain containing protein 0.01 0.1524 0.4214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0707 0.199
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0707 0.199
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0236 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0707 0.199
Leishmania major hypothetical protein, conserved 0.0065 0.0869 0.5627
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0694 0.0694
Entamoeba histolytica protein tyrosine phosphatase, putative 0.021 0.3552 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Echinococcus multilocularis dual specificity 0.01 0.1524 0.1524
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0047 0.006
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.021 0.3552 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0047 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0047 0.006
Brugia malayi hypothetical protein 0.002 0.0036 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0694 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1098 0.6999
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0104 0.0293
Brugia malayi hypothetical protein 0.0019 0.0026 0.0073
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.038 0.1069
Echinococcus granulosus dna polymerase kappa 0.0023 0.0104 0.0104
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.021 0.3552 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0694 0.1955
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.1524 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0694 0.0694

Activities

Activity type Activity value Assay description Source Reference
EC50 (ADMET) = 2.178 um PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR). (Class of assay: confirmatory) [Related pubchem assays: 2796 (Primary screen (AHR activators in singlicate)), 2845 (Confirmation screen (AHR activators in triplicate)), 434939 (Counterscreen (PXR activators in triplicate)), 2804 (Summary (AHR activators))] ChEMBL. No reference
EC50 (ADMET) > 116.115 um PUBCHEM_BIOASSAY: Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR). (Class of assay: confirmatory) [Related pubchem assays: 2796 (Primary screen (AHR activators in singlicate)), 2845 (Confirmation screen (AHR activators in triplicate)), 434939 (Counterscreen (PXR activators in triplicate)), 2804 (Summary (AHR activators))] ChEMBL. No reference
Potency (functional) = 0.0794 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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