TDR Targets

Basic information

Technical information

TDR Targets ID: 1340761
Name: furan-2-yl-[4-[4-methyl-1,1-dioxo-5-(4-propan -2-ylphenyl)-1,2-thiazol-3-yl]piperazin-1-yl] methanone
MW: 427.517 | Formula: C22H25N3O4S
H donors: 0 H acceptors: 3 LogP: 2.71 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC1=C(c2ccc(cc2)C(C)C)S(=O)(=O)N=C1N1CCN(CC1)C(=O)c1ccco1
InChi: 1S/C22H25N3O4S/c1-15(2)17-6-8-18(9-7-17)20-16(3)21(23-30(20,27)28)24-10-12-25(13-11-24)22(26)19-5-4-14-29-19/h4-9,14-15H,10-13H2,1-3H3
InChiKey: DEANCAUANVTPPW-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-furyl-[4-[5-(4-isopropylphenyl)-4-methyl-1,1-dioxo-isothiazol-3-yl]piperazin-1-yl]methanone
2-furyl-[4-[5-(4-isopropylphenyl)-4-methyl-1,1-dioxo-3-isothiazolyl]-1-piperazinyl]methanone
2-furyl-[4-[5-(4-isopropylphenyl)-1,1-diketo-4-methyl-isothiazol-3-yl]piperazin-1-yl]methanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references
Schistosoma mansoni	Thioredoxin glutathione reductase	Starlite/ChEMBL	No references
Homo sapiens	vitamin D (1,25- dihydroxyvitamin D3) receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Cryptosporidium parvum	thioredoxin reductase 1	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	Glutathione reductase, related	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania donovani	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	Thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Theileria parva	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Toxoplasma gondii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma cruzi	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania mexicana	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma congolense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania infantum	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei gambiense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	MGC84926 protein, related	Get druggable targets OG5_126785	All targets in OG5_126785
Babesia bovis	thiodoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium hominis	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus multilocularis	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania major	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Plasmodium knowlesi	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	518 aa	22.0 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Plasmodium berghei	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	538 aa	25.3 %
Onchocerca volvulus		Thioredoxin glutathione reductase	598 aa	533 aa	50.8 %
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	521 aa	21.5 %
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	Thioredoxin glutathione reductase	598 aa	513 aa	25.0 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Brugia malayi	steroid hormone receptor	vitamin D (1,25- dihydroxyvitamin D3) receptor	427 aa	416 aa	24.5 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Neospora caninum	Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related	Thioredoxin glutathione reductase	598 aa	512 aa	28.3 %
Toxoplasma gondii	NADPH-glutathione reductase	Thioredoxin glutathione reductase	598 aa	555 aa	33.5 %
Plasmodium yoelii	dihydrolipoamide dehydrogenase	Thioredoxin glutathione reductase	598 aa	537 aa	24.2 %
Neospora caninum	glutathione reductase, putative	Thioredoxin glutathione reductase	598 aa	532 aa	34.6 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Neospora caninum	hypothetical protein	Thioredoxin glutathione reductase	598 aa	485 aa	30.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0179	0.0114
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.008	0.0903	0.0903
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0048	0.0066	0.0093
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0052	0.0179	0.0179
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0334	0.7705	0.7689
Echinococcus granulosus	protein kinase shaggy	0.0048	0.0066	0.005
Echinococcus multilocularis	serine protein kinase ATM	0.008	0.0903	0.0888
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.1146	0.1087
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0061	0.0422	0.0406
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0421	1	1
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0048	0.0066	0.0066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0313	0.7125	0.7106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.008	0.0903	0.0843
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.008	0.0903	0.0903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0313	0.7125	0.7106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.4839	0.4805
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0061	0.0422	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1068	0.1068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.483	0.4796
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0141	0.2544	0.2531
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0048	0.0066	0.0066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.008	0.0903	0.0843
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0422	0.0358
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0141	0.2544	0.2494
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0249	0.5418	0.5388
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0422	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0334	0.7705	0.7689
Trypanosoma cruzi	target of rapamycin kinase 3	0.0335	0.7714	0.7714
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.4839	0.4805
Trypanosoma brucei	protein kinase, putative	0.0048	0.0066	0.0066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.483	0.4796
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.008	0.0903	0.0888
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0251	0.5485	0.5455
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0421	1	1
Echinococcus granulosus	serine protein kinase ATM	0.008	0.0903	0.0888
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.008	0.0903	0.0903
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.1561	0.8342
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0141	0.2544	0.2531
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0421	1	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.1871	1
Brugia malayi	intracellular kinase	0.0048	0.0066	0.0066
Plasmodium falciparum	glycogen synthase kinase 3	0.0048	0.0066	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0175	0.3441	0.3441
Onchocerca volvulus		0.0048	0.0066	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1146	0.1146
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0421	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0421	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.2544	0.2494
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0141	0.2544	0.2544
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.2544	0.2544
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0251	0.5485	0.5455
Loa Loa (eye worm)	phosphatidylinositol 3	0.0421	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0141	0.2544	0.2544
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0141	0.2544	0.2544
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.008	0.0903	0.0888
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0141	0.2544	0.2544
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0421	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0334	0.7705	0.7689
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0089	0.1146	0.1608
Entamoeba histolytica	protein kinase rad3, putative	0.008	0.0903	0.0843
Trichomonas vaginalis	PIKK family atypical protein kinase	0.008	0.0903	0.0843
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0141	0.2544	0.2544
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.2544	0.2544
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0048	0.0066	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0313	0.7125	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0313	0.7125	0.7106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0251	0.5485	0.5455
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.1871	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.483	0.4796
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0249	0.5418	0.5388
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.2544	0.2494
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0421	1	1
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0048	0.0066	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.2544	0.2494
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.008	0.0903	0.0903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0313	0.7125	0.7106
Brugia malayi	FAT domain containing protein	0.0061	0.0422	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0273	0.6064	0.6038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.1791	0.1737
Entamoeba histolytica	hypothetical protein	0.008	0.0903	0.0843
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.1561	0.8342
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0421	1	1
Echinococcus multilocularis	protein kinase shaggy	0.0048	0.0066	0.005
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.1561	0.8342
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0179	0.0179
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.2544	0.2494
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.008	0.0903	0.0843
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0335	0.7714	0.7714
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0421	1	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.1871	1
Giardia lamblia	GTOR	0.0421	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0359	0.836	0.8349
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0179	0.0114
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.1561	0.8342
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0421	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0421	1	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.1871	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.008	0.0903	0.0843
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.2544	0.2494
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0421	1	1
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0048	0.0066	0.005
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0048	0.0066	0.0066
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0421	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0199	0.4087	0.4087
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0048	0.0066	0.0066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0334	0.7705	0.7689
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.4839	0.4805
Schistosoma mansoni	hypothetical protein	0.0061	0.0422	0.0358
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0313	0.7125	0.7106
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0421	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0313	0.7125	0.7106
Mycobacterium tuberculosis	Probable reductase	0.0104	0.1561	0.8342
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.1561	0.8342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0282	0.6307	0.6282
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0313	0.7125	0.7106
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.008	0.0903	0.0903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0334	0.7705	0.7689
Toxoplasma gondii	FATC domain-containing protein	0.008	0.0903	0.1268
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.4839	0.4805
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.008	0.0903	0.0843
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0335	0.7714	0.7714
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0141	0.2544	0.2544
Loa Loa (eye worm)	hypothetical protein	0.008	0.0903	0.0903

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1.4125 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (binding)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	26.6795 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	39.8107 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1499124

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1340761