Detailed information for compound 1344260

Basic information

Technical information
  • TDR Targets ID: 1344260
  • Name: 2-(2,4-dichlorophenoxy)-N'-(2-oxo-2-piperidin -1-ylacetyl)propanehydrazide
  • MW: 388.246 | Formula: C16H19Cl2N3O4
  • H donors: 2 H acceptors: 3 LogP: 3.69 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Oc1ccc(cc1Cl)Cl)C)NNC(=O)C(=O)N1CCCCC1
  • InChi: 1S/C16H19Cl2N3O4/c1-10(25-13-6-5-11(17)9-12(13)18)14(22)19-20-15(23)16(24)21-7-3-2-4-8-21/h5-6,9-10H,2-4,7-8H2,1H3,(H,19,22)(H,20,23)
  • InChiKey: MEYBMOGMGNVNTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,4-dichlorophenoxy)-N'-[2-oxo-2-(1-piperidyl)acetyl]propanehydrazide
  • 2-(2,4-dichlorophenoxy)-N'-[1,2-dioxo-2-(1-piperidyl)ethyl]propanehydrazide
  • 2-(2,4-dichlorophenoxy)-N'-(2-keto-2-piperidino-acetyl)propionohydrazide
  • 2-(2,4-dichlorophenoxy)-N'-(2-oxo-2-piperidin-1-yl-ethanoyl)propanehydrazide
  • SMR000176163
  • BAS 00847841
  • 2-(2,4-Dichloro-phenoxy)-propionic acid N'-(2-oxo-2-piperidin-1-yl-acetyl)-hydrazide
  • MLS000562309

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sentrin specific protease 1 0.0046 0.0016 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0157 0.0456
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0196 0.0636 0.0979
Echinococcus multilocularis peptidase Clp (S14 family) 0.0317 0.1136 0.3293
Toxoplasma gondii LsmAD domain-containing protein 0.0101 0.0242 0.125
Brugia malayi MH2 domain containing protein 0.0168 0.0517 0.0517
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0081 0.0157 0.0456
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0157 0.0456
Schistosoma mansoni steroid hormone receptor ad4bp 0.0081 0.0157 0.0456
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0484 0.1826 0.281
Entamoeba histolytica hypothetical protein 0.0113 0.0291 1
Schistosoma mansoni tar DNA-binding protein 0.0877 0.345 1
Schistosoma mansoni hypothetical protein 0.0326 0.117 0.3392
Echinococcus multilocularis mothers against decapentaplegic 5 0.0168 0.0517 0.1499
Echinococcus multilocularis thyroid hormone receptor alpha 0.0081 0.0157 0.0456
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0201 0.1955
Schistosoma mansoni peptidase Clp (S14 family) 0.0484 0.1826 0.5292
Brugia malayi Latrophilin receptor protein 2 0.0181 0.0574 0.0574
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0011 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.0081 0.0157 0.0157
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0081 0.0157 0.0456
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.0242 0.125
Brugia malayi MH1 domain containing protein 0.0168 0.0517 0.0517
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0016 0.0046
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0196 0.0636 0.1843
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0196 0.0636 0.3426
Loa Loa (eye worm) pip kinase 2 0.0162 0.0494 0.0494
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0291 0.0844
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.0242 0.125
Brugia malayi nuclear hormone receptor 0.0081 0.0157 0.0157
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0196 0.0636 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0406 0.1504 0.1504
Echinococcus granulosus Smad4 0.0168 0.0517 0.0796
Loa Loa (eye worm) hypothetical protein 0.0186 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0093 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0181 0.0574 0.1665
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0201 0.1955
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0081 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0101 0.0242 0.0242
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0081 0.0157 0.0242
Echinococcus granulosus peptidase Clp S14 family 0.0317 0.1136 0.1749
Onchocerca volvulus Protein ultraspiracle homolog 0.0081 0.0157 0.0054
Echinococcus granulosus smad 0.0168 0.0517 0.0796
Brugia malayi ecdysteroid receptor 0.0081 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0157 0.0157
Brugia malayi TAR-binding protein 0.0877 0.345 0.345
Echinococcus multilocularis tar DNA binding protein 0.0877 0.345 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0081 0.0157 0.0157
Brugia malayi MH2 domain containing protein 0.0168 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0392 0.1445 0.1445
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0081 0.0157 0.0157
Loa Loa (eye worm) isocitrate dehydrogenase 0.0196 0.0636 0.0636
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0317 0.1136 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0075 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0081 0.0157 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0081 0.0157 0.0157
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.0593 0.1073
Loa Loa (eye worm) hypothetical protein 0.0081 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0484 0.1826 0.1826
Schistosoma mansoni Smad4 0.0075 0.0134 0.0388
Brugia malayi MH1 domain containing protein 0.0093 0.0207 0.0207
Echinococcus granulosus TGF beta signal transducer SmadC 0.0168 0.0517 0.0796
Entamoeba histolytica hypothetical protein 0.0113 0.0291 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0168 0.0517 0.0517
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0181 0.0574 0.0884
Echinococcus multilocularis ecdysone induced protein 78C 0.0081 0.0157 0.0456
Echinococcus granulosus GPCR family 2 0.0181 0.0574 0.0884
Echinococcus multilocularis FTZ F1 alpha 0.0406 0.1504 0.4358
Brugia malayi nuclear receptor NHR-88 0.0081 0.0157 0.0157
Loa Loa (eye worm) MH1 domain-containing protein 0.0075 0.0134 0.0134
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0081 0.0157 0.0456
Loa Loa (eye worm) TAR-binding protein 0.0877 0.345 0.345
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0162 0.0494 0.0761
Brugia malayi Smad1 0.0168 0.0517 0.0517
Schistosoma mansoni tar DNA-binding protein 0.0877 0.345 1
Brugia malayi hypothetical protein 0.0113 0.0291 0.0291
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0201 0.0201
Toxoplasma gondii hypothetical protein 0.0167 0.0514 0.275
Schistosoma mansoni smad 0.0075 0.0134 0.0388
Schistosoma mansoni smad1 5 8 and 0.0168 0.0517 0.1499
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0081 0.0157 0.0157
Brugia malayi photoreceptor-specific nuclear receptor 0.0081 0.0157 0.0157
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0317 0.1136 0.4744
Loa Loa (eye worm) latrophilin receptor protein 2 0.0181 0.0574 0.0574
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0201 0.1955
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0196 0.0636 0.1843
Brugia malayi Probable ClpP-like protease 0.0484 0.1826 0.1826
Brugia malayi hypothetical protein 0.0101 0.0242 0.0242
Loa Loa (eye worm) nuclear factor I 0.0093 0.0207 0.0207
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0484 0.1826 0.5
Leishmania major hypothetical protein, conserved 0.0101 0.0242 0.0939
Loa Loa (eye worm) Smad1 0.0168 0.0517 0.0517
Onchocerca volvulus 0.0162 0.0494 0.0843
Loa Loa (eye worm) hypothetical protein 0.0081 0.0157 0.0157
Echinococcus multilocularis mothers against decapentaplegic 2 0.0075 0.0134 0.0388
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.0242 0.0939
Schistosoma mansoni Smad4 0.0168 0.0517 0.1499
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0081 0.0157 0.0456
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0081 0.0157 0.0456
Plasmodium vivax ataxin-2 like protein, putative 0.0101 0.0242 0.125
Onchocerca volvulus 0.0081 0.0157 0.0054
Brugia malayi steroid hormone receptor 0.0081 0.0157 0.0157
Onchocerca volvulus Bile acid receptor homolog 0.0081 0.0157 0.0054
Brugia malayi glutaminase DH11.1 0.0281 0.0985 0.0985
Schistosoma mansoni kinase 0.0046 0.0016 0.0046
Brugia malayi isocitrate dehydrogenase 0.0196 0.0636 0.0636
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0484 0.1826 1
Echinococcus granulosus tar DNA binding protein 0.0877 0.345 0.531
Schistosoma mansoni hypothetical protein 0.0181 0.0574 0.1665
Brugia malayi MH1 domain containing protein 0.0168 0.0517 0.0517
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0162 0.0494 0.1433
Echinococcus multilocularis smad 0.0168 0.0517 0.1499
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0484 0.1826 0.5292
Schistosoma mansoni coup transcription factor 0.0081 0.0157 0.0456
Loa Loa (eye worm) glutaminase 0.0281 0.0985 0.0985
Brugia malayi N-terminal motif family protein 0.0186 0.0593 0.0593
Schistosoma mansoni RAR-like nuclear receptor 0.0081 0.0157 0.0456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0081 0.0157 0.0157
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0181 0.0574 0.1665
Schistosoma mansoni tar DNA-binding protein 0.0877 0.345 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0181 0.0574 0.1665
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0046 0.0016 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0157 0.0157
Loa Loa (eye worm) MH1 domain-containing protein 0.0168 0.0517 0.0517
Giardia lamblia Kinase, PLK 0.0091 0.0201 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.2461 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0877 0.345 0.345
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0011 0.0033
Onchocerca volvulus 0.111 0.4412 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0081 0.0157 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0201 0.1955
Toxoplasma gondii isocitrate dehydrogenase 0.0196 0.0636 0.3426
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0157 0.0242
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0877 0.345 0.345
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0201 0.1955
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0291 0.0844
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0167 0.0514 0.275
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0168 0.0517 0.1499
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0016 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0877 0.345 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0016 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0081 0.0157 0.0456
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0196 0.0636 0.3426
Brugia malayi MH2 domain containing protein 0.0075 0.0134 0.0134
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0168 0.0517 0.1499
Brugia malayi hypothetical protein 0.111 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0406 0.1504 0.1504
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0484 0.1826 0.5
Loa Loa (eye worm) hypothetical protein 0.0181 0.0574 0.0574
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0484 0.1826 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0484 0.1826 1
Schistosoma mansoni hypothetical protein 0.0181 0.0574 0.1665
Echinococcus granulosus FTZ F1 alpha 0.1614 0.6497 1
Schistosoma mansoni hypothetical protein 0.0045 0.0011 0.0033
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0406 0.1504 0.4358
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0201 0.1955
Schistosoma mansoni glutaminase 0.0281 0.0985 0.2855
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0181 0.0574 0.0574
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0081 0.0157 0.0456
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0484 0.1826 1
Schistosoma mansoni hypothetical protein 0.0113 0.0291 0.0844
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0196 0.0636 1
Brugia malayi latrophilin 2 splice variant baaae 0.0392 0.1445 0.1445
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0574 0.2195 0.2195
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0201 0.0583
Schistosoma mansoni hypothetical protein 0.0181 0.0574 0.1665
Brugia malayi RNA binding protein 0.0877 0.345 0.345
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0201 0.031
Echinococcus multilocularis mothers against decapentaplegic 6 0.0075 0.0134 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0081 0.0157 0.0157
Entamoeba histolytica hypothetical protein 0.0113 0.0291 1
Loa Loa (eye worm) RNA binding protein 0.0877 0.345 0.345
Schistosoma mansoni Smad4 0.0075 0.0134 0.0388
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0484 0.1826 1
Echinococcus multilocularis GPCR, family 2 0.0181 0.0574 0.1665
Echinococcus granulosus sentrin specific protease 1 0.0046 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0075 0.0134 0.0134
Schistosoma mansoni thyroid hormone receptor 0.0081 0.0157 0.0456
Brugia malayi Steroid receptor seven-up type 2 0.0081 0.0157 0.0157
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0201 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0201 0.1955
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0317 0.1136 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0157 0.0157
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0484 0.1826 1
Schistosoma mansoni retinoic acid receptor RXR 0.0081 0.0157 0.0456
Brugia malayi Pip kinase protein 2 0.0162 0.0494 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0081 0.0157 0.0157
Schistosoma mansoni smad1 5 8 and 0.0168 0.0517 0.1499
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0081 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0081 0.0157 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0081 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0081 0.0157 0.0157
Brugia malayi hypothetical protein 0.0065 0.0094 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0201 0.0583
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.0242 0.0939
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0081 0.0157 0.0054
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0162 0.0494 0.1433
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0291 0.0448
Loa Loa (eye worm) hypothetical protein 0.111 0.4412 0.4412
Echinococcus granulosus mothers against decapentaplegic 6 0.0075 0.0134 0.0206
Loa Loa (eye worm) hypothetical protein 0.0081 0.0157 0.0157
Brugia malayi Isocitrate dehydrogenase 0.0196 0.0636 0.0636
Toxoplasma gondii isocitrate dehydrogenase 0.0196 0.0636 0.3426
Loa Loa (eye worm) glutaminase 2 0.0281 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0162 0.0494 0.0494
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0196 0.0636 0.1843
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0196 0.0636 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0574 0.2195 0.2195
Schistosoma mansoni hypothetical protein 0.0392 0.1445 0.4189
Schistosoma mansoni tar DNA-binding protein 0.0877 0.345 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0081 0.0157 0.0157
Brugia malayi MH1 domain containing protein 0.0093 0.0207 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0406 0.1504 0.1504
Loa Loa (eye worm) hypothetical protein 0.0081 0.0157 0.0157
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0081 0.0157 0.0242
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0196 0.0636 0.1843
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0196 0.0636 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0484 0.1826 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0081 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0081 0.0157 0.0157
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0574 0.2195 0.2195
Trypanosoma brucei PAB1-binding protein , putative 0.0101 0.0242 0.0939
Loa Loa (eye worm) hypothetical protein 0.0574 0.2195 0.2195
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0406 0.1504 0.4358
Trichomonas vaginalis glutaminase, putative 0.0281 0.0985 1
Loa Loa (eye worm) MH2 domain-containing protein 0.2461 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0201 0.6738
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0081 0.0157 0.0456
Schistosoma mansoni smad1 5 8 and 0.0168 0.0517 0.1499
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0484 0.1826 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0181 0.0574 0.0884
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0157 0.0242
Schistosoma mansoni smad 0.0168 0.0517 0.1499
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0081 0.0157 0.0242
Echinococcus multilocularis Smad4 0.0168 0.0517 0.1499
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0081 0.0157 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0081 0.0157 0.0157
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0196 0.0636 0.1843
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0406 0.1504 0.2314
Entamoeba histolytica hypothetical protein 0.0113 0.0291 1
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.0016 0.0016
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0157 0.0456
Echinococcus granulosus ecdysone induced protein 78C 0.0081 0.0157 0.0242
Echinococcus granulosus mothers against decapentaplegic 2 0.0075 0.0134 0.0206
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0196 0.0636 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0075 0.0134 0.0134
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0157 0.0157
Echinococcus multilocularis isocitrate dehydrogenase 0.0196 0.0636 0.1843
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0201 0.0158
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0162 0.0494 0.1433
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0484 0.1826 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0168 0.0517 0.0796
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0167 0.0514 0.275

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0657 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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