Detailed information for compound 1346390

Basic information

Technical information
  • TDR Targets ID: 1346390
  • Name: 3-hydroxyphenalen-1-one
  • MW: 196.201 | Formula: C13H8O2
  • H donors: 1 H acceptors: 2 LogP: 2.55 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1=CC(=O)c2c3c1cccc3ccc2
  • InChi: 1S/C13H8O2/c14-11-7-12(15)10-6-2-4-8-3-1-5-9(11)13(8)10/h1-7,14H
  • InChiKey: DXBYIIARRIMNFJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-hydroxy-1-phenalenone
  • 5472-84-4
  • 409707_ALDRICH
  • 1H-Phenalen-1-one, 9-hydroxy-
  • ZINC00162130
  • CBDivE_011649
  • 3-hydroxy-1H-phenalen-1-one
  • MLS001008607
  • SMR000495845
  • NSC29569

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens relaxin/insulin-like family peptide receptor 1 Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Protein Rev Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_127954 All targets in OG5_127954
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei sentrin-specific protease 1, putative Get druggable targets OG5_127954 All targets in OG5_127954
Leishmania infantum cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Plasmodium vivax sentrin-specific protease 1, putative Get druggable targets OG5_127954 All targets in OG5_127954
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum ko:K08592 sentrin-specific protease 1, putative Get druggable targets OG5_127954 All targets in OG5_127954
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Cryptosporidium parvum ULP1 like chllamydin domain containing protease Get druggable targets OG5_127954 All targets in OG5_127954
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei variant surface glycoprotein (VSG), putative Get druggable targets OG5_130635 All targets in OG5_130635
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma brucei calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Theileria parva hypothetical protein Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma brucei calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus sentrin specific protease 1 Get druggable targets OG5_127954 All targets in OG5_127954
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma congolense calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_127954 All targets in OG5_127954
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_127954 All targets in OG5_127954
Neospora caninum hypothetical protein Get druggable targets OG5_127954 All targets in OG5_127954
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma cruzi calpain cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_127954 All targets in OG5_127954
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis sentrin specific protease 1 Get druggable targets OG5_127954 All targets in OG5_127954
Plasmodium yoelii similar to sentrin/SUMO-specific protease Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Plasmodium knowlesi sentrin-specific protease 1, putative Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma brucei hypothetical protein Get druggable targets OG5_130635 All targets in OG5_130635
Babesia bovis ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_127954 All targets in OG5_127954
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum sentrin-specific protease 1 Get druggable targets OG5_127954 All targets in OG5_127954
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_127954 All targets in OG5_127954
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Leishmania infantum hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Leishmania donovani hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3371 1
Giardia lamblia Sentrin specific protease, putative 0.0016 0.0241 0.3667
Brugia malayi Flap endonuclease-1 0.0031 0.0656 0.0656
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0656 0.5024
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0241 0.1842
Echinococcus multilocularis sentrin specific protease 1 0.0056 0.1306 0.2516
Plasmodium vivax sentrin-specific protease 1, putative 0.0056 0.1306 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.3371 1
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.0241 0.1842
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0241 0.1842
Brugia malayi hypothetical protein 0.0043 0.097 0.097
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0241 0.0241
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.3371 1
Echinococcus multilocularis sentrin specific protease 8 0.0016 0.0241 0.0463
Schistosoma mansoni hypothetical protein 0.0205 0.519 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3371 1
Echinococcus granulosus hypothetical protein 0.0033 0.0693 0.1335
Brugia malayi hypothetical protein 0.0033 0.0693 0.0693
Loa Loa (eye worm) Ulp1 protease 0.0016 0.0241 0.0241
Entamoeba histolytica hypothetical protein 0.0043 0.097 0.743
Schistosoma mansoni hypothetical protein 0.0205 0.519 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0241 0.1842
Loa Loa (eye worm) Ulp1 protease 0.0016 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0016 0.0241 0.0241
Loa Loa (eye worm) tumor suppressor 0.0388 1 1
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0016 0.0241 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0693 0.0693
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0241 0.0241
Entamoeba histolytica hypothetical protein 0.0043 0.097 0.743
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.3371 1
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0656 0.0656
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3371 1
Trypanosoma brucei SUMO1/Ulp2, putative 0.0016 0.0241 0.0714
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0241 0.1842
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0056 0.1306 0.2516
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.097 0.1869
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0656 0.5024
Trypanosoma cruzi hypothetical protein 0.0016 0.0241 0.0714
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.0241 0.0463
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0241 0.1842
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.097 0.1869
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.3371 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0241 0.1842
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3371 1
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0693 0.0693
Loa Loa (eye worm) hypothetical protein 0.0016 0.0241 0.0241
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0056 0.1306 1
Echinococcus granulosus sentrin specific protease 8 0.0016 0.0241 0.0463
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3371 1
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0656 0.5024
Plasmodium falciparum flap endonuclease 1 0.0031 0.0656 0.5024
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0656 0.5024
Trypanosoma brucei hypothetical protein 0.0135 0.3371 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0241 0.1842
Trypanosoma brucei calpain, putative 0.0135 0.3371 1
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0016 0.0241 0.1842
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3371 1
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0016 0.0241 0.0714
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0656 0.1946
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0056 0.1306 1
Echinococcus multilocularis geminin 0.0205 0.519 1
Echinococcus granulosus flap endonuclease 1 0.0031 0.0656 0.1264
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3371 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0056 0.1306 0.2516
Entamoeba histolytica hypothetical protein 0.0043 0.097 0.743
Onchocerca volvulus 0.0016 0.0241 0.5
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.0033 0.0693 0.1335
Entamoeba histolytica hypothetical protein 0.0043 0.097 0.743
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.0241 0.1842
Plasmodium falciparum sentrin-specific protease 1 0.0056 0.1306 1
Echinococcus granulosus sentrin specific protease 7 0.0016 0.0241 0.0463
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0016 0.0241 0.0714
Echinococcus granulosus geminin 0.0205 0.519 1
Trypanosoma brucei calpain-like protein, putative 0.0135 0.3371 1
Echinococcus granulosus sentrin specific protease 1 0.0056 0.1306 0.2516
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0241 0.1842
Echinococcus multilocularis sentrin specific protease 7 0.0016 0.0241 0.0463
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0241 0.1842
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0656 0.1946
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.3371 1
Schistosoma mansoni hypothetical protein 0.0043 0.097 0.1869
Loa Loa (eye worm) hypothetical protein 0.0056 0.1306 0.1306
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0016 0.0241 0.5
Plasmodium vivax sentrin-specific protease 2, putative 0.0016 0.0241 0.1842
Trichomonas vaginalis Sentrin-specific protease, putative 0.0016 0.0241 0.1842
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.097 0.1869
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0656 1
Echinococcus granulosus protein quaking 0.0033 0.0693 0.1335
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0056 0.1306 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0016 0.0241 0.0714
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3371 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0656 0.1946
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0241 0.1842
Schistosoma mansoni flap endonuclease-1 0.0028 0.0577 0.1112
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0056 0.1306 0.1306
Echinococcus multilocularis protein quaking 0.0033 0.0693 0.1335
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0241 0.1842
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.3371 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.3371 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0241 0.1842
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.0241 0.0463
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0656 0.1264
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0241 0.1842
Schistosoma mansoni hypothetical protein 0.0033 0.0693 0.1335
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0241 0.1842

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.133 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (functional) 8.55 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 13.1 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 13.868 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
IC50 (functional) = 33.1 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 34.52 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1458 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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