Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2 (5-HT2) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.0808 | 0.1512 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0057 | 0.019 | 0.019 |
Entamoeba histolytica | glucosamine-6-phosphate isomerase, putative | 0.0044 | 0.0091 | 0.5 |
Leishmania major | N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase | 0.0044 | 0.0091 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.005 | 0.0137 | 0.0137 |
Plasmodium vivax | N-acetylglucosaminylphosphatidylinositol deacetylase, putative | 0.0044 | 0.0091 | 0.5 |
Entamoeba histolytica | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative | 0.0044 | 0.0091 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0667 | 0.4837 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0138 | 0.0808 | 0.1512 |
Giardia lamblia | Glucosamine-6-phosphate isomerase, putative | 0.0044 | 0.0091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0808 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.017 | 0.1049 | 1 |
Mycobacterium tuberculosis | N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) | 0.0044 | 0.0091 | 0.0094 |
Mycobacterium tuberculosis | Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) | 0.1299 | 0.9662 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.017 | 0.1049 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0053 | 0.0159 | 0.0145 |
Mycobacterium ulcerans | mycothiol conjugate amidase Mca | 0.1344 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.0808 | 0.1512 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 0.0808 | 1 |
Plasmodium falciparum | N-acetylglucosaminylphosphatidylinositol deacetylase, putative | 0.0044 | 0.0091 | 0.5 |
Toxoplasma gondii | N-acetylglucosaminylphosphatidylinositol deacetylase | 0.0044 | 0.0091 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.0808 | 0.1512 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0053 | 0.0159 | 0.0145 |
Trypanosoma cruzi | N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative | 0.0044 | 0.0091 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0667 | 0.4837 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0044 | 0.0091 | 0.0094 |
Mycobacterium ulcerans | N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB | 0.0044 | 0.0091 | 0.0091 |
Trypanosoma cruzi | N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative | 0.0044 | 0.0091 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.0808 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0057 | 0.019 | 0.0197 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.008 | 0.0364 | 0.0377 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0113 | 0.0611 | 0.0611 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.0808 | 0.1512 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.008 | 0.0364 | 0.0364 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0057 | 0.019 | 0.019 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.0808 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0667 | 0.4837 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.008 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0808 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.017 | 0.1049 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.0808 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.0808 | 0.1512 |
Trypanosoma brucei | N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase | 0.0044 | 0.0091 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0138 | 0.0808 | 0.1512 |
Schistosoma mansoni | lipoxygenase | 0.0053 | 0.0159 | 0.0145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.62 mg kg-1 | Ability to inhibit apomorphine-induced climbing behavior in mice. | ChEMBL. | 7707315 |
ED50 (functional) | = 0.62 mg kg-1 | Ability to inhibit apomorphine-induced climbing behavior in mice. | ChEMBL. | 7707315 |
ED50 (functional) | = 7.1 mg kg-1 | Ability to block apomorphine-induced stereotypy in rats. | ChEMBL. | 7707315 |
IC50 (binding) | = 33 nM | Affinity for 5-hydroxytryptamine 2 receptor binding sites by its ability to displace [3H]-spiperone from rat frontal cortex. | ChEMBL. | 7707315 |
IC50 (binding) | = 33 nM | Affinity for 5-hydroxytryptamine 2 receptor binding sites by its ability to displace [3H]-spiperone from rat frontal cortex. | ChEMBL. | 7707315 |
IC50 (binding) | = 364 nM | Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]-spiperone from rat striatum. | ChEMBL. | 7707315 |
IC50 (binding) | = 364 nM | Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]-spiperone from rat striatum. | ChEMBL. | 7707315 |
Ratio (binding) | = 11 | Ratio of IC50 value against dopamine receptor D2 to that of 5-hydroxytryptamine 3 receptor. | ChEMBL. | 7707315 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.