Detailed information for compound 1349474

Basic information

Technical information
  • TDR Targets ID: 1349474
  • Name: 5-bromo-4,6-dimethyl-2-oxo-1H-pyridine-3-carb onitrile
  • MW: 227.058 | Formula: C8H7BrN2O
  • H donors: 1 H acceptors: 3 LogP: 2.56 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(O)nc(c(c1C)Br)C
  • InChi: 1S/C8H7BrN2O/c1-4-6(3-10)8(12)11-5(2)7(4)9/h1-2H3,(H,11,12)
  • InChiKey: DFGKQCOFARYQOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-bromo-2-keto-4,6-dimethyl-1H-pyridine-3-carbonitrile
  • 23819-87-6
  • MLS000089917
  • SMR000024535
  • ST5209082
  • ZINC00168891
  • 5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum phosphoglycerate kinase 0.0175 0.1126 0.1142
Schistosoma mansoni alpha glucosidase 0.004 0.0213 0.0205
Schistosoma mansoni hypothetical protein 0.0189 0.1226 0.1219
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0202 0.0856
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0009 0.0037
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0213 0.1673
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0099 0.0347
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0099 0.0347
Schistosoma mansoni DNA polymerase eta 0.002 0.0073 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0031 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Brugia malayi Phosphoglycerate kinase 0.0175 0.1126 0.9395
Brugia malayi steroid hormone receptor 0.001 0.0009 0.0028
Trichomonas vaginalis ran, putative 0.0024 0.0099 0.0637
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.004 0.0099
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0374 0.1709
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0116 0.0787
Leishmania major hypothetical protein, conserved 0.0026 0.0114 0.0419
Entamoeba histolytica hypothetical protein 0.0043 0.0234 0.178
Giardia lamblia DINP protein human, muc B family 0.002 0.0073 0.0394
Toxoplasma gondii hypothetical protein 0.005 0.0278 0.0259
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0363 0.0355
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1424 0.9627 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.2045 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0069 0.0197
Trypanosoma brucei unspecified product 0.002 0.0073 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0037
Plasmodium falciparum importin beta, putative 0.0032 0.0157 0.0133
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0234 0.1016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0009
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.0935 0.4494
Schistosoma mansoni hypothetical protein 0.0189 0.1226 0.1219
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0116 0.0787
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0319
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0099 0.0099
Schistosoma mansoni ap endonuclease 0.0019 0.0069 0.0061
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0202 0.077
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0607 0.2581
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0175 0.1126 0.1142
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.054 0.2281
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0069 0.0197
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0213 0.1673
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0114 0.0088
Echinococcus multilocularis dna polymerase eta 0.002 0.0073 0.0073
Brugia malayi hypothetical protein 0.0026 0.0114 0.0911
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0073 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0037
Entamoeba histolytica hypothetical protein 0.0026 0.0116 0.0695
Echinococcus granulosus lysosomal alpha glucosidase 0.0182 0.1177 0.1177
Brugia malayi Thioredoxin reductase 0.0039 0.0202 0.165
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0029 0.0204
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0009 0.0009
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0175 0.1126 0.5437
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1424 0.9627 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0317 0.1391
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0073 0.0566
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0037
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0058 0.0442
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0058 0.0058
Echinococcus granulosus GPCR family 2 0.0018 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0028
Schistosoma mansoni ran 0.0024 0.0099 0.0091
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0073 0.0214
Entamoeba histolytica hypothetical protein 0.0043 0.0234 0.178
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.004 0.0099
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0099 0.0347
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0202 0.0886
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0073 0.0045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.069
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0073 0.0073
Toxoplasma gondii exonuclease III APE 0.0019 0.0069 0.0041
Echinococcus granulosus dna polymerase kappa 0.002 0.0073 0.0073
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0205 0.0205
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0009 0.0028
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0073 0.0073
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0069 0.0197
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0213 0.1673
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0177
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0234 0.0234
Plasmodium vivax glutathione reductase, putative 0.0039 0.0202 0.018
Loa Loa (eye worm) hypothetical protein 0.0185 0.1198 0.5257
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0069 0.0363
Echinococcus multilocularis phosphoglycerate kinase 1 0.0175 0.1126 0.1126
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0073 0.0394
Entamoeba histolytica phosphoglycerate kinase, putative 0.0175 0.1126 1
Echinococcus multilocularis microtubule associated protein 2 0.1479 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0073 0.0298
Schistosoma mansoni cpg binding protein 0.0031 0.015 0.0141
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.054 0.2281
Loa Loa (eye worm) glutathione reductase 0.0039 0.0202 0.0886
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0099 0.0073
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0099 0.079
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0213 0.0213
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0935 0.4494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0037
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0234 0.1016
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Schistosoma mansoni hypothetical protein 0.0344 0.2278 0.2272
Leishmania major phosphoglycerate kinase B, cytosolic 0.0175 0.1126 0.5437
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0009
Echinococcus granulosus phosphoglycerate kinase 1 0.0175 0.1126 0.1126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0028
Onchocerca volvulus 0.0105 0.0654 0.5431
Leishmania major DNA polymerase eta, putative 0.002 0.0073 0.0214
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0213 0.1673
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0317 0.1391
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0157 0.0157
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0213 0.1589
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0317 0.2615
Schistosoma mansoni alpha-glucosidase 0.0157 0.1004 0.0997
Loa Loa (eye worm) hypothetical protein 0.0018 0.0058 0.0254
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.004 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0009 0.0028
Brugia malayi hypothetical protein 0.0017 0.0052 0.0389
Leishmania major DNA polymerase kappa, putative 0.002 0.0073 0.0214
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1424 0.9627 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0009 0.0037
Giardia lamblia Phosphoglycerate kinase 0.0175 0.1126 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0073 0.0394
Schistosoma mansoni hypothetical protein 0.0012 0.0017 0.0008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0058 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.004 0.0099
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0175 0.1126 0.4896
Schistosoma mansoni phosphoglycerate kinase 0.0175 0.1126 0.1118
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0073 0.0214
Leishmania major glycosyl hydrolase-like protein 0.0015 0.004 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0318 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Brugia malayi nuclear hormone receptor 0.001 0.0009 0.0028
Echinococcus granulosus FTZ F1 alpha 0.001 0.0009 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0214
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0234 0.1016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0037
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.004 0.0054
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0009 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0114 0.0088
Schistosoma mansoni alpha-glucosidase 0.0157 0.1004 0.0997
Schistosoma mansoni hypothetical protein 0.0043 0.0234 0.0225
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0205 0.0205
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0213 0.1673
Chlamydia trachomatis phosphoglycerate kinase 0.0175 0.1126 0.1142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0069 0.0197
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0234 0.0225
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0009 0.0009
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0343 0.2268 1
Trypanosoma brucei trypanothione reductase 0.0039 0.0202 0.0856
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0049
Plasmodium falciparum phosphoglycerate kinase 0.0175 0.1126 0.1142
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0175 0.1126 0.0644
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0099 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0213 0.091
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.2045 1
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0213 0.0213
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0009 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0114 0.0419
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.004 0.0099
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0114 0.0419
Echinococcus granulosus dna polymerase eta 0.002 0.0073 0.0073
Echinococcus multilocularis snurportin 1 0.0344 0.2278 0.2278
Trypanosoma brucei unspecified product 0.0014 0.0031 0.0007
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0073 0.0566
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0299 0.1338
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1424 0.9627 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0009
Plasmodium vivax phosphoglycerate kinase, putative 0.0175 0.1126 0.1142
Schistosoma mansoni microtubule-associated protein tau 0.1479 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.054 0.2281
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0099 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Echinococcus multilocularis GPCR, family 2 0.0018 0.0058 0.0058
Brugia malayi RNA, U transporter 1 0.0092 0.0561 0.4664
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0069 0.0537
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.004 0.0295
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0157 0.0634
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0317 0.2615
Onchocerca volvulus 0.0029 0.0138 0.1092
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0073 0.0214
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0607 0.2581
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0073 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0214
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0058 0.0058
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0073 0.0193
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0865
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0069 0.0363
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0069 0.0041
Mycobacterium ulcerans phosphoglycerate kinase 0.0175 0.1126 0.1142
Schistosoma mansoni hypothetical protein 0.0038 0.0197 0.0189
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.1177 0.1177
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0175 0.1126 0.1142
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0049
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0157 0.0133
Trypanosoma brucei phosphoglycerate kinase 0.0175 0.1126 0.5437
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0607 0.2581
Leishmania major trypanothione reductase 0.0039 0.0202 0.0856
Echinococcus granulosus importin subunit beta 1 0.0032 0.0157 0.0157
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.054 0.2281
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.1177 0.1177
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0058 0.0254
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0069 0.0069
Brugia malayi N-terminal motif family protein 0.0185 0.1198 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.004 0.0099
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.004 0.0054
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0069 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Echinococcus granulosus cpg binding protein 0.0031 0.015 0.015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.2045 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0374 0.1709
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0037
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0175 0.1126 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0028
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0099 0.0099
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0157 0.0634
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0037
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0069 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0037
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0607 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0214
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0213 0.1589
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.004 0.0099
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0213 0.0191
Echinococcus granulosus geminin 0.0189 0.1226 0.1226
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0073 0.0319
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.1198 1
Plasmodium falciparum thioredoxin reductase 0.0039 0.0202 0.018
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0114 0.0088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0069 0.0178
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.1048 0.455
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0028
Entamoeba histolytica hypothetical protein 0.0043 0.0234 0.178
Leishmania major mitochondrial DNA polymerase beta 0.031 0.2045 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0031 0.0007
Mycobacterium ulcerans hypothetical protein 0.0163 0.1048 0.1061
Brugia malayi ecdysteroid receptor 0.001 0.0009 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0213 0.1673
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0009 0.0009
Schistosoma mansoni importin beta-1 0.0032 0.0157 0.0149
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.004 0.0054
Leishmania major phosphoglycerate kinase C, glycosomal 0.0175 0.1126 0.5437
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0073 0.0193
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0029 0.0029
Brugia malayi nuclear receptor NHR-88 0.001 0.0009 0.0028
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.1424 0.9627 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0073 0.0064
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1424 0.9627 1
Plasmodium falciparum glutathione reductase 0.0039 0.0202 0.018
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0037
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0202 0.018
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0028
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1424 0.9627 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0114 0.0419
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0116 0.0787
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.004 0.0099
Brugia malayi Importin beta-1 subunit 0.0032 0.0157 0.1275
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0182 0.1177 0.5165
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0073 0.0045
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0234 0.1016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0213 0.1673
Echinococcus multilocularis cpg binding protein 0.0031 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0037
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0197 0.1609
Schistosoma mansoni phosphoglycerate kinase 0.0175 0.1126 0.1118
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0935 0.4494
Brugia malayi hypothetical protein 0.0043 0.0234 0.1915
Leishmania major importin beta-1 subunit, putative 0.0026 0.0116 0.0428
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0028
Brugia malayi glutathione reductase 0.0039 0.0202 0.165
Echinococcus granulosus snurportin 1 0.0344 0.2278 0.2278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0009 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0214
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0069 0.0304
Schistosoma mansoni ran 0.0024 0.0099 0.0091
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1424 0.9627 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0374 0.1709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0114 0.05
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0058 0.0058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0069 0.0069
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0213 0.0934
Brugia malayi Glycosyl hydrolases family 31 protein 0.0182 0.1177 0.9824
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Schistosoma mansoni cpg binding protein 0.0029 0.0138 0.013
Brugia malayi CXXC zinc finger family protein 0.0029 0.0138 0.1117
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0138 0.0607
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0073 0.0214
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0009 0.0028
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0049
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0069 0.0363
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0234 0.0234
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0099 0.0073
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0064 0.0374 0.1709
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0116 0.0428
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0069 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0037
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0213 0.1673
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0009
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0069 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0028
Toxoplasma gondii thioredoxin reductase 0.0039 0.0202 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0073 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0031 0.0007
Schistosoma mansoni cpg binding protein 0.0031 0.015 0.0141
Entamoeba histolytica Ran family GTPase 0.0024 0.0099 0.0543
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0099 0.0637
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0029 0.0029
Plasmodium vivax importin-beta 2, putative 0.0032 0.0157 0.0133
Trypanosoma brucei phosphoglycerate kinase, putative 0.0064 0.0374 0.1709
Schistosoma mansoni ap endonuclease 0.0019 0.0069 0.0061
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0114 0.0088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0069 0.0041
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0009
Trypanosoma brucei glucosidase, putative 0.004 0.0213 0.091
Trypanosoma brucei phosphoglycerate kinase 0.0175 0.1126 0.5437
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0017 0.0017
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0213 0.091
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0009 0.0009
Leishmania major GTP-binding protein, putative 0.0024 0.0099 0.0347
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0374 0.1709
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0175 0.1126 0.5437
Trypanosoma brucei phosphoglycerate kinase 0.0064 0.0374 0.1709
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0029 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.004 0.0099
Echinococcus multilocularis dna polymerase kappa 0.002 0.0073 0.0073
Trypanosoma brucei unspecified product 0.0014 0.0031 0.0007
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0213 0.1673
Echinococcus multilocularis geminin 0.0189 0.1226 0.1226
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0374 0.1709
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.054 0.2281
Entamoeba histolytica hypothetical protein 0.0043 0.0234 0.178
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0175 0.1126 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0214
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0213 0.091
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0017 0.0017
Brugia malayi Phosphoglycerate kinase 0.0064 0.0374 0.3092
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0028
Mycobacterium tuberculosis Probable reductase 0.0089 0.054 0.2281
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0058 0.0442
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0213 0.1741
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0049
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0175 0.1126 0.1142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0037
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0344 0.2278 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.1126 0.4941

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0033 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.2593 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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